PMID- 32431107
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20240219
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Print)
IS  - 2233-6079 (Linking)
VI  - 45
IP  - 2
DP  - 2021 Mar
TI  - Insulin Resistance Increases Serum Immunoglobulin E Sensitization in 
      Premenopausal Women.
PG  - 175-182
LID - 10.4093/dmj.2019.0150 [doi]
AB  - BACKGROUND: Although studies have shown that obesity is associated with 
      aeroallergen sensitization (atopy), controversy still exists. We aimed to 
      investigate the association between metabolic status, obesity, and atopy 
      stratified by sex and menopausal status. METHODS: A total of 1,700 adults from 
      the 2010 Korean National Health and Nutrition Examination Survey were classified 
      into metabolically healthy nonobese (MHNO), metabolically unhealthy nonobese 
      (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese 
      (MUO) by body mass index and insulin resistance. Atopy was defined as a positive 
      response to at least one aeroallergen. Multiple regression analysis was used to 
      evaluate the risk of immunoglobulin E (IgE) elevation or atopy in relation to the 
      degree of metabolic abnormality and obesity. RESULTS: In premenopausal women, 
      total IgE was positively correlated with obesity and insulin resistance. MUNO 
      participants had a higher risk of having elevated total IgE compared to MHNO 
      participants (odds ratio [OR], 2.271; 95% confidence interval [CI], 1.201 to 
      4.294), while MHO participants did not show a significant difference (OR, 1.435; 
      95% CI, 0.656 to 3.137) in premenopausal women. MUNO, but not MHO was also 
      associated with atopy (OR, 2.157; 95% CI, 1.284 to 3.625). In men and 
      postmenopausal women, there was no significant difference between metabolic 
      status, obesity, and atopy among groups. CONCLUSION: Increased insulin resistance 
      is associated with total IgE and atopy in premenopausal women but not in 
      postmenopausal women or men.
FAU - Lee, Seung Eun
AU  - Lee SE
AD  - Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk 
      University College of Medicine, Goyang, Korea.
FAU - Baek, Ji Yeon
AU  - Baek JY
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Korea.
FAU - Han, Kyungdo
AU  - Han K
AD  - Department of Biostatistics, The Catholic University of Korea, Seoul, Korea.
FAU - Koh, Eun Hee
AU  - Koh EH
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20200414
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E
MH  - *Insulin Resistance
MH  - Male
MH  - Nutrition Surveys
MH  - Risk Factors
PMC - PMC8024158
OTO - NOTNLM
OT  - Immunoglobulin E
OT  - Insulin resistance
OT  - Metabolic syndrome
OT  - Obesity
COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2020/05/21 06:00
MHDA- 2021/10/16 06:00
PMCR- 2021/03/01
CRDT- 2020/05/21 06:00
PHST- 2019/07/31 00:00 [received]
PHST- 2019/12/10 00:00 [accepted]
PHST- 2020/05/21 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2020/05/21 06:00 [entrez]
PHST- 2021/03/01 00:00 [pmc-release]
AID - 44.e15 [pii]
AID - dmj-2019-0150 [pii]
AID - 10.4093/dmj.2019.0150 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2021 Mar;45(2):175-182. doi: 10.4093/dmj.2019.0150. Epub 2020 
      Apr 14.