PMID- 32431281 OWN - NLM STAT- MEDLINE DCOM- 20201109 LR - 20220316 IS - 1476-1645 (Electronic) IS - 0002-9637 (Print) IS - 0002-9637 (Linking) VI - 103 IP - 2 DP - 2020 Aug TI - Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease. PG - 745-751 LID - tpmd200122 [pii] LID - 10.4269/ajtmh.20-0122 [doi] AB - Chronic Chagas disease can progress to myocardial involvement with intense fibrosis, which may predispose patients to sudden cardiac death through ventricular arrhythmia. The associations of myocardial fibrosis detected by cardiac magnetic resonance (CMR) parameters with non-sustained ventricular tachycardia (NSVT) were evaluated. This cross-sectional study included patients in early stages of Chagas disease (n = 47) and a control group (n = 15). Patients underwent cardiac evaluation, including CMR examination. Myocardial fibrosis assessment by CMR with measurement of late gadolinium enhancement (LGE), native T1, and extracellular volume (ECV) was performed. There was an increase in myocardial fibrosis CMR parameters and ventricular arrhythmias among different stages of Chagas disease, combined with a decrease in the left ventricular ejection fraction (LVEF) by CMR and also in the right ventricular systolic function by S' wave on tissue Doppler. Fibrosis mass and ECV were associated with the Rassi score, ventricular extrasystole, and E/e' ratio in a logistic regression model adjusted for age and gender. The ECV maintained an association with the presence of NSVT, even after adjustments for fibrosis mass and LVEF assessed by CMR. The receiver-operating characteristic area under the curve for global ECV (0.85; 95% CI: 0.71-0.99) and NSVT was greater than that for fibrosis mass (0.75; 95% CI: 0.54-0.96), although this difference was not statistically significant. Extracellular volume could be an early marker of increased risk of ventricular arrhythmia in Chagas disease, presenting an independent association with NSVT in the initial stages of chronic Chagas cardiomyopathy, even after adjustment for fibrosis mass and LVEF. FAU - Pinheiro, Martha Valeria Tavares AU - Pinheiro MVT AD - 1D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil. FAU - Moll-Bernardes, Renata Junqueira AU - Moll-Bernardes RJ AD - 1D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil. FAU - Camargo, Gabriel Cordeiro AU - Camargo GC AD - 1D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil. AD - 2National Institute of Cardiology, Rio de Janeiro, Brazil. FAU - Siqueira, Fabio Paiva AU - Siqueira FP AD - 1D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil. FAU - Azevedo, Clerio Francisco de AU - Azevedo CF AD - 3Duke University Medical Center, Durham, North Carolina. FAU - Holanda, Marcelo Teixeira de AU - Holanda MT AD - 4Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Mendes, Fernanda de Souza Nogueira Sardinha AU - Mendes FSNS AD - 4Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Sangenis, Luiz Henrique Conde AU - Sangenis LHC AD - 4Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Mediano, Mauro Felippe Felix AU - Mediano MFF AD - 2National Institute of Cardiology, Rio de Janeiro, Brazil. AD - 4Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Sousa, Andrea Silvestre de AU - Sousa AS AD - 1D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil. AD - 4Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200514 PL - United States TA - Am J Trop Med Hyg JT - The American journal of tropical medicine and hygiene JID - 0370507 SB - IM MH - Aged MH - Area Under Curve MH - Case-Control Studies MH - Chagas Cardiomyopathy/complications/diagnostic imaging/*physiopathology MH - Chagas Disease/complications/diagnostic imaging/physiopathology MH - Cross-Sectional Studies MH - Echocardiography MH - Electrocardiography, Ambulatory MH - Extracellular Space MH - Female MH - Fibrosis MH - Heart/*diagnostic imaging MH - Humans MH - Logistic Models MH - Magnetic Resonance Imaging MH - Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Myocardium/pathology MH - Organ Size MH - ROC Curve MH - Stroke Volume MH - Tachycardia, Ventricular/etiology/*physiopathology MH - Ventricular Function, Right PMC - PMC7410430 EDAT- 2020/05/21 06:00 MHDA- 2020/11/11 06:00 PMCR- 2021/08/01 CRDT- 2020/05/21 06:00 PHST- 2020/05/21 06:00 [pubmed] PHST- 2020/11/11 06:00 [medline] PHST- 2020/05/21 06:00 [entrez] PHST- 2021/08/01 00:00 [pmc-release] AID - tpmd200122 [pii] AID - 10.4269/ajtmh.20-0122 [doi] PST - ppublish SO - Am J Trop Med Hyg. 2020 Aug;103(2):745-751. doi: 10.4269/ajtmh.20-0122. Epub 2020 May 14.