PMID- 32431659
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 11
DP  - 2020
TI  - Cerebral Hemodynamic Changes After Endovascular Recanalization of Symptomatic 
      Chronic Intracranial Artery Occlusion.
PG  - 318
LID - 10.3389/fneur.2020.00318 [doi]
LID - 318
AB  - Objective: We performed this study to evaluate the hemodynamic changes over time 
      after successful endovascular recanalization in patients with symptomatic chronic 
      intracranial artery occlusion (CIAO). Materials and Methods: We included 20 
      patients with symptomatic CIAO in a high-volume stroke center from June 2014 to 
      June 2019. All subjects were evaluated with CT perfusion (CTP) studies before and 
      after the recanalization. The relative cerebral blood flows (rCBFs) in 
      perforating artery territory (PAT) and cortical artery territory (CAT) of 
      occluded arteries were compared before and after the recanalization. The patients 
      were categorized into subgroups based on the time interval from revascularization 
      to post-procedural CTP, occlusion sites, and restenosis status. The proportion of 
      rCBF change (rCBFc%) was compared in variable subgroups. Results: The rCBF 
      increased significantly from 0.52 to 0.71 in PAT (P < 0.001) and from 0.59 to 
      0.85 in CAT (P < 0.001) after recanalization, and there were also statistical 
      differences in variable subgroups except for those with restenosis. The median 
      and interquartile range (IQR) of rCBFc% were 35.2 and 18.6-56.6%. For patients 
      with short-term follow-up (55.2%), the rCBFc% was relatively higher than that in 
      patients with mid-term (35.4%) and long-term follow-up (32.7%), although without 
      statistical difference (P = 0.273). For patients with restenosis, the rCBFc% was 
      significantly lower than that in patients without restenosis (18.5 vs. 37.3%, P = 
      0.008). Conclusions: In patients with symptomatic CIAO, the CBF may increase and 
      be relatively stable over time after successful recanalization except for 
      restenosis.
CI  - Copyright (c) 2020 Kang, Yang, Gong, Chen, Gu, Ma, Miao, Zhao and Ma.
FAU - Kang, Kaijiang
AU  - Kang K
AD  - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, China.
AD  - China National Clinical Research Center for Neurological Diseases, Center of 
      Stroke, Beijing Institute for Brain Disorders, Beijing, China.
FAU - Yang, Bo
AU  - Yang B
AD  - China National Clinical Research Center for Neurological Diseases, Center of 
      Stroke, Beijing Institute for Brain Disorders, Beijing, China.
AD  - Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital 
      Medical University, Beijing, China.
AD  - Department of Neurology, Beijing Jiangong Hospital, Beijing, China.
FAU - Gong, Xiping
AU  - Gong X
AD  - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, China.
AD  - China National Clinical Research Center for Neurological Diseases, Center of 
      Stroke, Beijing Institute for Brain Disorders, Beijing, China.
FAU - Chen, Xing
AU  - Chen X
AD  - Beijing Advanced Innovation Center for Biomedical Engineering, Beihang 
      University, Beijing, China.
FAU - Gu, Weibin
AU  - Gu W
AD  - China National Clinical Research Center for Neurological Diseases, Center of 
      Stroke, Beijing Institute for Brain Disorders, Beijing, China.
AD  - Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, China.
FAU - Ma, Guofeng
AU  - Ma G
AD  - China National Clinical Research Center for Neurological Diseases, Center of 
      Stroke, Beijing Institute for Brain Disorders, Beijing, China.
AD  - Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, China.
FAU - Miao, Zhongrong
AU  - Miao Z
AD  - China National Clinical Research Center for Neurological Diseases, Center of 
      Stroke, Beijing Institute for Brain Disorders, Beijing, China.
AD  - Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital 
      Medical University, Beijing, China.
FAU - Zhao, Xingquan
AU  - Zhao X
AD  - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, China.
AD  - China National Clinical Research Center for Neurological Diseases, Center of 
      Stroke, Beijing Institute for Brain Disorders, Beijing, China.
FAU - Ma, Ning
AU  - Ma N
AD  - China National Clinical Research Center for Neurological Diseases, Center of 
      Stroke, Beijing Institute for Brain Disorders, Beijing, China.
AD  - Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital 
      Medical University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20200505
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC7214835
OTO - NOTNLM
OT  - CT perfusion
OT  - hemodynamics
OT  - intracranial occlusion
OT  - recanalization
OT  - stroke
EDAT- 2020/05/21 06:00
MHDA- 2020/05/21 06:01
PMCR- 2020/05/05
CRDT- 2020/05/21 06:00
PHST- 2019/10/31 00:00 [received]
PHST- 2020/03/31 00:00 [accepted]
PHST- 2020/05/21 06:00 [entrez]
PHST- 2020/05/21 06:00 [pubmed]
PHST- 2020/05/21 06:01 [medline]
PHST- 2020/05/05 00:00 [pmc-release]
AID - 10.3389/fneur.2020.00318 [doi]
PST - epublish
SO  - Front Neurol. 2020 May 5;11:318. doi: 10.3389/fneur.2020.00318. eCollection 2020.