PMID- 32431666 OWN - NLM STAT- MEDLINE DCOM- 20210528 LR - 20210528 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 11 DP - 2020 TI - The Association Between Acylcarnitine Metabolites and Cardiovascular Disease in Chinese Patients With Type 2 Diabetes Mellitus. PG - 212 LID - 10.3389/fendo.2020.00212 [doi] LID - 212 AB - Objective: The association between acylcarnitine metabolites and cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to investigate associations between acylcarnitines and CVD in Chinese patients with T2DM. Methods: A cross-sectional study was conducted from May 2015 to August 2016. Medical records of 741 patients with T2DM were retrieved from the main electronic database of Liaoning Medical University First Affiliated Hospital. CVD was defined as having either coronary artery disease (CAD) or heart failure (HF) or stroke. Mass Spectrometry was utilized to measure levels of 25 acylcarnitine metabolites in fasting plasma. Factor analysis was used to reduce the dimensions and extracted factors of the 25 acylcarnitine metabolites. Multivariable binary logistic regression was used to obtain odds ratios (OR) of the factors extracted from the 25 acylcarnitine metabolites and their 95% confidence intervals (CI) for CVD. Results: Of the 741 patients with T2DM, 288 had CVD. Five factors were extracted from the 25 acylcarnitines and they accounted for 65.9% of the total variance. Factor 1 consisted of acetylcarnitine, butyrylcarnitine, hydroxylbutyrylcarnitine, glutarylcarnitine, hexanoylcarnitine, octanoylcarnitine, and tetradecanoyldiacylcarnitine. Factor 2 consisted of decanoylcarnitine, lauroylcarnitine, myristoylcarnitine, 3-hydroxyl-tetradecanoylcarnitine, tetradecenoylcarnitine, and 3-hydroxypalmitoylcarnitine. After adjusting for potential confounders, increased factor 1 and 2 were associated with increased risks of CVD in T2DM (OR of factor 1: 1.45, 95% CI: 1.03-2.03; OR of factor 2: 1.23, 95% CI: 1.02-1.50). Conclusions: Elevated plasma levels of some acylcarnitine metabolites, i.e., those extracted into factor 1 and 2, were associated with CVD risk in T2DM. CI - Copyright (c) 2020 Zhao, Feng, Huang, Luo, Chen, Zeng, Gu, Li, Sun, Sun, Yang, Fang and Cao. FAU - Zhao, Shuo AU - Zhao S AD - Department of Pathology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China. FAU - Feng, Xiao-Fei AU - Feng XF AD - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Huang, Ting AU - Huang T AD - Shanghai Engineering Research Center of Reproductive Health Drug and Devices, NHC Key Laboratory of Contraceptives and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai, China. FAU - Luo, Hui-Huan AU - Luo HH AD - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Chen, Jian-Xin AU - Chen JX AD - Shanghai Engineering Research Center of Reproductive Health Drug and Devices, NHC Key Laboratory of Contraceptives and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai, China. FAU - Zeng, Jia AU - Zeng J AD - Shanghai Engineering Research Center of Reproductive Health Drug and Devices, NHC Key Laboratory of Contraceptives and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai, China. FAU - Gu, Muyu AU - Gu M AD - Central Laboratory of Preventive Medicine, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Li, Jing AU - Li J AD - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Sun, Xiao-Yu AU - Sun XY AD - Key Laboratory of Liaoning Tumor Clinical Metabolomics (KLLTCM), Jinzhou, China. FAU - Sun, Dan AU - Sun D AD - College of Life Sciences, NanKai University, Tianjin, China. FAU - Yang, Xilin AU - Yang X AD - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China. AD - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. FAU - Fang, Zhong-Ze AU - Fang ZZ AD - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China. AD - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. FAU - Cao, Yun-Feng AU - Cao YF AD - Shanghai Engineering Research Center of Reproductive Health Drug and Devices, NHC Key Laboratory of Contraceptives and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200505 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Biomarkers) RN - 0 (acylcarnitine) RN - S7UI8SM58A (Carnitine) SB - IM MH - Aged MH - Biomarkers/*blood/metabolism MH - Cardiovascular Diseases/*diagnosis/etiology/metabolism MH - Carnitine/*analogs & derivatives/metabolism MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/*complications MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - *Metabolome MH - Middle Aged MH - Prognosis PMC - PMC7214635 OTO - NOTNLM OT - Chinese OT - acylcarnitine OT - cardiovascular disease OT - metabolism OT - type 2 diabetes mellitus EDAT- 2020/05/21 06:00 MHDA- 2021/05/29 06:00 PMCR- 2020/01/01 CRDT- 2020/05/21 06:00 PHST- 2019/06/29 00:00 [received] PHST- 2020/03/25 00:00 [accepted] PHST- 2020/05/21 06:00 [entrez] PHST- 2020/05/21 06:00 [pubmed] PHST- 2021/05/29 06:00 [medline] PHST- 2020/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2020.00212 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2020 May 5;11:212. doi: 10.3389/fendo.2020.00212. eCollection 2020.