PMID- 32435396
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210514
IS  - 1948-5875 (Print)
IS  - 1948-5875 (Electronic)
IS  - 1948-5875 (Linking)
VI  - 11
IP  - 5
DP  - 2020 May 14
TI  - Inhibition of Human Immunodeficiency Virus-1 Integrase by beta-Diketo Acid Coated 
      Gold Nanoparticles.
PG  - 857-861
LID - 10.1021/acsmedchemlett.9b00648 [doi]
AB  - Gold nanoparticles (GNPs) have been proposed as carriers for drugs to improve 
      their intrinsic therapeutic activities and to overcome pharmacokinetic problems. 
      In this study, novel nanosystems constituted by a model beta-diketo acid (DKA) 
      grafted to the surface of GNPs were designed and synthesized following the 
      "multivalent high-affinity" binding strategy. These first nanoscale DKA 
      prototypes showed improved inhibition of HIV-1 integrase (HIV-1 IN) catalytic 
      activities as compared with free DKA ligands.
CI  - Copyright (c) 2020 American Chemical Society.
FAU - Sanna, Vanna
AU  - Sanna V
AD  - Nanomater s.r.l., c/o Porto Conte Ricerche, Alghero, Italy.
FAU - Youssef, Mohamed Fathy
AU  - Youssef MF
AD  - Department of Chemistry and Pharmacy, Laboratory of Drug Design and Nanomedicine, 
      University of Sassari, 07100 Sassari, Italy.
FAU - Pala, Nicolino
AU  - Pala N
AD  - Department of Chemistry and Pharmacy, Laboratory of Drug Design and Nanomedicine, 
      University of Sassari, 07100 Sassari, Italy.
FAU - Rogolino, Dominga
AU  - Rogolino D
AD  - Department of Chemistry, Life Sciences and Environmental Sustainability, 
      University of Parma, Parco Area delle Scienze, 43121 Parma, Italy.
FAU - Carcelli, Mauro
AU  - Carcelli M
AD  - Department of Chemistry, Life Sciences and Environmental Sustainability, 
      University of Parma, Parco Area delle Scienze, 43121 Parma, Italy.
FAU - Singh, Pankaj Kumar
AU  - Singh PK
AD  - Department of Chemistry and Pharmacy, Laboratory of Drug Design and Nanomedicine, 
      University of Sassari, 07100 Sassari, Italy.
FAU - Sanchez, Tino
AU  - Sanchez T
AD  - National Center for Advancing Translational Sciences - NIH, Rockville, Maryland 
      20850, United States.
FAU - Neamati, Nouri
AU  - Neamati N
AD  - Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 
      Ann Arbor, Michigan 48109, United States.
FAU - Sechi, Mario
AU  - Sechi M
AD  - Department of Chemistry and Pharmacy, Laboratory of Drug Design and Nanomedicine, 
      University of Sassari, 07100 Sassari, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200320
PL  - United States
TA  - ACS Med Chem Lett
JT  - ACS medicinal chemistry letters
JID - 101521073
PMC - PMC7236234
COIS- The authors declare no competing financial interest.
EDAT- 2020/05/22 06:00
MHDA- 2020/05/22 06:01
PMCR- 2021/05/14
CRDT- 2020/05/22 06:00
PHST- 2019/12/24 00:00 [received]
PHST- 2020/03/20 00:00 [accepted]
PHST- 2020/05/22 06:00 [entrez]
PHST- 2020/05/22 06:00 [pubmed]
PHST- 2020/05/22 06:01 [medline]
PHST- 2021/05/14 00:00 [pmc-release]
AID - 10.1021/acsmedchemlett.9b00648 [doi]
PST - epublish
SO  - ACS Med Chem Lett. 2020 Mar 20;11(5):857-861. doi: 
      10.1021/acsmedchemlett.9b00648. eCollection 2020 May 14.