PMID- 32436432
OWN - NLM
STAT- MEDLINE
DCOM- 20210308
LR  - 20231111
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 48
IP  - 5
DP  - 2020 May
TI  - Altered features of neurotransmitters: NPY, alpha-MSH, and AgRP in type 2 diabetic 
      patients with hypertension.
PG  - 300060520919580
LID - 10.1177/0300060520919580 [doi]
LID - 0300060520919580
AB  - OBJECTIVE: To investigate the features of neuropeptide Y (NPY), alpha-melanocyte 
      stimulating hormone (alpha-MSH), and agouti-related protein (AgRP) in type 2 diabetes 
      mellitus (T2DM) patients with hypertension. METHODS: Patients with T2DM (n = 384) 
      and healthy volunteers (n = 80) were enrolled into this study. Serum NPY, alpha-MSH, 
      and AgRP levels were detected using ELISA. RESULTS: Significantly higher NPY and 
      lower alpha-MSH and AgRP levels were observed in patients with diabetes compared with 
      those without diabetes, and the mean NPY levels increased, while alpha-MSH and AgRP 
      levels decreased, with the development of hypertension compared with diabetic 
      patients without hypertension. alpha-MSH and AgRP levels decreased with an increase 
      in blood pressure in hypertension compared with the non-hypertension patients. 
      Multiple stepwise linear regression analysis showed that NPY, alpha-MSH, and AgRP 
      levels were closely associated with blood pressure and glucose control. Receiver 
      operating characteristic (ROC) curve analyses indicated that alpha-MSH may be a 
      better marker compared with NPY and AgRP for regulating glucose and blood 
      pressure and to distinguish between T2DM patients with and without hypertension. 
      CONCLUSION: NPY, alpha-MSH, and AgRP might play different roles and be closely 
      related to the occurrence and development of diabetes and hypertension.
FAU - Li, Baoxin
AU  - Li B
AD  - Department of Endocrinology, Baoding NO. 1 Central Hospital, Baoding, Hebei, 
      China.
FAU - Ma, Shuang
AU  - Ma S
AD  - Department of Endocrinology, Baoding NO. 1 Central Hospital, Baoding, Hebei, 
      China.
FAU - Guo, Shuqin
AU  - Guo S
AD  - Department of Endocrinology, Baoding NO. 1 Central Hospital, Baoding, Hebei, 
      China.
FAU - Li, Na
AU  - Li N
AD  - Department of Endocrinology, Baoding NO. 1 Central Hospital, Baoding, Hebei, 
      China.
FAU - Liu, Dandan
AU  - Liu D
AD  - Department of Endocrinology, Baoding NO. 1 Central Hospital, Baoding, Hebei, 
      China.
FAU - Wang, He
AU  - Wang H
AD  - Department of Endocrinology, Baoding NO. 1 Central Hospital, Baoding, Hebei, 
      China.
FAU - Zhai, Na
AU  - Zhai N
AD  - Department of Endocrinology, Baoding NO. 1 Central Hospital, Baoding, Hebei, 
      China.
FAU - Zhang, Yunliang
AU  - Zhang Y
AUID- ORCID: 0000-0002-0511-1071
AD  - Department of Endocrinology, Baoding NO. 1 Central Hospital, Baoding, Hebei, 
      China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (AGRP protein, human)
RN  - 0 (Agouti-Related Protein)
RN  - 0 (Biomarkers)
RN  - 0 (Neuropeptide Y)
RN  - 581-05-5 (alpha-MSH)
SB  - IM
MH  - Aged
MH  - Agouti-Related Protein/*blood/metabolism
MH  - Animals
MH  - Biomarkers/blood/metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/complications/*metabolism
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Hypertension/blood/complications/*diagnosis/metabolism
MH  - Male
MH  - Middle Aged
MH  - Neuropeptide Y/*blood/metabolism
MH  - ROC Curve
MH  - alpha-MSH/*blood/metabolism
PMC - PMC7243407
OTO - NOTNLM
OT  - AgRP
OT  - NPY
OT  - Type 2 diabetes mellitus
OT  - glucose control
OT  - hypertension
OT  - alpha-MSH
EDAT- 2020/05/22 06:00
MHDA- 2021/03/09 06:00
PMCR- 2020/05/21
CRDT- 2020/05/22 06:00
PHST- 2020/05/22 06:00 [entrez]
PHST- 2020/05/22 06:00 [pubmed]
PHST- 2021/03/09 06:00 [medline]
PHST- 2020/05/21 00:00 [pmc-release]
AID - 10.1177_0300060520919580 [pii]
AID - 10.1177/0300060520919580 [doi]
PST - ppublish
SO  - J Int Med Res. 2020 May;48(5):300060520919580. doi: 10.1177/0300060520919580.