PMID- 32437071
OWN - NLM
STAT- MEDLINE
DCOM- 20210719
LR  - 20231104
IS  - 2053-1095 (Electronic)
IS  - 2053-1095 (Linking)
VI  - 6
IP  - 4
DP  - 2020 Nov
TI  - Comparative evaluation of 4 commercial modified-live porcine reproductive and 
      respiratory syndrome virus (PRRSV) vaccines against heterologous dual Korean 
      PRRSV-1 and PRRSV-2 challenge.
PG  - 846-853
LID - 10.1002/vms3.282 [doi]
AB  - BACKGROUND: Four commercial porcine reproductive and respiratory syndrome virus 
      (PRRSV) modified-live vaccines (MLV) was compared to protect growing pigs against 
      dual challenge of PRRSV-1 and PRRSV-2. METHODS: Two of the vaccines were based on 
      PRRSV-1, and two on PRRSV-2. A total of 72 PRRSV-naive pigs were divided into six 
      groups (12 pigs/group). RESULTS: Two PRRSV-1 MLV-vaccinated and two PRRSV-2 
      MLV-vaccinated groups reduced significantly (p < .05) genomic copies of PRRSV-1 
      in their sera compared to the unvaccinated challenged group. Two PRRSV-2 
      MLV-vaccinated groups reduced significantly (p < .05) fewer genomic copies of 
      PRRSV-2 in their sera whereas two PRRSV-1 MLV-vaccinated groups were unable to 
      reduce genomic copies of PRRSV-2 compared to unvaccinated challenged groups. Two 
      PRRSV-1 MLV-vaccinated groups induced a stronger PRRSV-1 specific IFN-gamma-SC 
      response, while two PRRSV-2 MLV-vaccinated groups induced a stronger PRRSV-2 
      specific IFN-gamma-SC response. Two PRRSV-2 MLV-vaccinated groups showed 
      significantly (p < .05) lower mean macroscopic and microscopic lung lesion scores 
      compared to two PRRSV-1 MLV-vaccinated groups. CONCLUSIONS: These data 
      demonstrated that two PRRSV-2 vaccines were efficacious and exhibited similar 
      protection while, two PRRSV-1 vaccines were largely ineffective against the dual 
      challenge.
CI  - (c) 2020 The Authors. Veterinary Medicine and Science Published by John Wiley & 
      Sons Ltd.
FAU - Oh, Taehwan
AU  - Oh T
AUID- ORCID: 0000-0001-9308-5573
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Park, Su-Jin
AU  - Park SJ
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Cho, Hyejean
AU  - Cho H
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Yang, Siyeon
AU  - Yang S
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Ham, Hee Jin
AU  - Ham HJ
AD  - College of Liberal Arts, Anyang University, Anyang-si, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AUID- ORCID: 0000-0002-0190-1957
AD  - College of Veterinary Medicine, Department of Veterinary Pathology, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200521
PL  - England
TA  - Vet Med Sci
JT  - Veterinary medicine and science
JID - 101678837
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Republic of Korea
MH  - Sus scrofa
MH  - Swine
MH  - Vaccination/veterinary
MH  - Vaccines, Attenuated/immunology
MH  - Viral Vaccines/*immunology
PMC - PMC7738743
OTO - NOTNLM
OT  - co-infection
OT  - modified-live virus vaccine
OT  - porcine reproductive and respiratory syndrome
OT  - vaccination
COIS- The authors declare no conflict of interests with respect to their authorship or 
      the publication of this article.
EDAT- 2020/05/22 06:00
MHDA- 2021/07/20 06:00
PMCR- 2020/05/21
CRDT- 2020/05/22 06:00
PHST- 2020/03/17 00:00 [received]
PHST- 2020/04/19 00:00 [revised]
PHST- 2020/04/25 00:00 [accepted]
PHST- 2020/05/22 06:00 [pubmed]
PHST- 2021/07/20 06:00 [medline]
PHST- 2020/05/22 06:00 [entrez]
PHST- 2020/05/21 00:00 [pmc-release]
AID - VMS3282 [pii]
AID - 10.1002/vms3.282 [doi]
PST - ppublish
SO  - Vet Med Sci. 2020 Nov;6(4):846-853. doi: 10.1002/vms3.282. Epub 2020 May 21.