PMID- 32437247
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 128
IP  - 6
DP  - 2020 Jun 1
TI  - The right ventricular myocardial systolic-to-diastolic duration ratio in children 
      after surgical repair of Tetralogy of Fallot.
PG  - 1677-1683
LID - 10.1152/japplphysiol.00775.2019 [doi]
AB  - Right ventricular (RV) function impacts clinical outcomes after surgical repair 
      of Tetralogy of Fallot (rTOF). However, assessment of RV function remains 
      difficult. We investigated the RV myocardial systolic-to-diastolic (S/D) duration 
      ratio derived from strain imaging time intervals to characterize RV myocardial 
      performance, exploring its relation with peak oxygen consumption during exercise 
      (V̇o(2)) and cardiac magnetic resonance-derived RV dilation and function in rTOF. 
      We retrospectively analyzed 76 children with rTOF and 42 normal controls. The RV 
      myocardial S/D duration ratio was measured from RV global and regional 2D speckle 
      tracking longitudinal strain. Time from QRS onset to peak systolic strain was 
      defined as the systolic duration. The S/D duration ratio was calculated and 
      corrected for heart rate (HR). Postsystolic shortening (PSS) duration was defined 
      as shortening time after cessation of pulmonary systolic antegrade flow. The RV 
      myocardial S/D duration ratio, corrected or uncorrected for HR, was significantly 
      higher in rTOF vs. controls (1 +/- 0.3 vs. 0.8 +/- 0.2, P = 0.004) in relation to 
      prolonged PSS. The HR-corrected myocardial S/D duration ratio correlated weakly 
      with RV ejection fraction (EF, r = -0.37, P = 0.001) and V̇o(2) (r = -0.32, P = 
      0.042). In multiregression analysis, RV EF was independently associated with the 
      myocardial S/D duration ratio. The RV myocardial S/D duration ratio is a 
      parameter of RV myocardial performance and efficiency, incorporating elements of 
      systolic and diastolic performance, mechanical dyssynchrony, and PSS. The S/D 
      duration ratio is associated with exercise capacity and RV dysfunction in 
      rTOF.NEW & NOTEWORTHY This is the first study to assess right ventricular 
      myocardial performance using the systolic-to-diastolic duration ratio derived 
      from 2D strain. Seventy-six children with repaired Tetralogy of Fallot were 
      evaluated. Echocardiographic data were correlated with cardiac magnetic resonance 
      and peak oxygen consumption during exercise. The results show the right 
      ventricular myocardial systolic-to-diastolic duration ratio incorporates systolic 
      and diastolic performance, electromechanical dyssynchrony, and postsystolic 
      shortening and is associated with exercise capacity in repaired Tetralogy of 
      Fallot.
FAU - Hui, Wei
AU  - Hui W
AD  - Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick 
      Children and University of Toronto, Canada.
FAU - Slorach, Cameron
AU  - Slorach C
AD  - Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick 
      Children and University of Toronto, Canada.
FAU - Iori, Susan
AU  - Iori S
AD  - Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick 
      Children and University of Toronto, Canada.
FAU - Dragulescu, Andreea
AU  - Dragulescu A
AD  - Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick 
      Children and University of Toronto, Canada.
FAU - Mertens, Luc
AU  - Mertens L
AD  - Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick 
      Children and University of Toronto, Canada.
FAU - Friedberg, Mark K
AU  - Friedberg MK
AD  - Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick 
      Children and University of Toronto, Canada.
LA  - eng
PT  - Journal Article
DEP - 20200521
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
SB  - IM
MH  - Child
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Retrospective Studies
MH  - *Tetralogy of Fallot/surgery
MH  - *Ventricular Dysfunction, Right
MH  - Ventricular Function, Right
OTO - NOTNLM
OT  - S/D duration ratio
OT  - Tetralogy of Fallot
OT  - myocardial strain
OT  - right ventricle
EDAT- 2020/05/22 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/05/22 06:00
PHST- 2020/05/22 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/05/22 06:00 [entrez]
AID - 10.1152/japplphysiol.00775.2019 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2020 Jun 1;128(6):1677-1683. doi: 
      10.1152/japplphysiol.00775.2019. Epub 2020 May 21.