PMID- 32439593
OWN - NLM
STAT- MEDLINE
DCOM- 20210329
LR  - 20210329
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 142
DP  - 2020 Aug
TI  - Cumulative dietary risk assessment overarching different regulatory silos using a 
      margin of exposure approach: A case study with three chemical silos.
PG  - 111416
LID - S0278-6915(20)30306-9 [pii]
LID - 10.1016/j.fct.2020.111416 [doi]
AB  - Risk assessment of chemicals occurring in our diet is commonly performed for 
      single chemicals without considering exposure to other chemicals. We performed a 
      case study on risk assessment of combined dietary exposure to chemicals from 
      different regulatory silos, i.e. pesticides (PPRs), persistent organic pollutants 
      (POPs) and food additives (FAs). Chemicals were grouped into the cumulative 
      assessment group (CAG) liver steatosis using a component-based approach. Based on 
      literature, the CAG included 144 PPRs, 49 POPS and 7 FAs for which concentration 
      data were available. For each silo, chronic combined dietary exposure was 
      assessed for adults and children of nine European countries following the most 
      commonly used exposure methodologies in Europe and by using a relative potency 
      factor approach. For risk characterization, a Margin of Exposure (MOE) was 
      calculated. To overarch the risk across silos, a normalised combined margin of 
      exposure (nMOET) approach was proposed. This case study demonstrated that risk 
      assessment of combined exposure to chemicals can be performed within regulatory 
      silos. It also highlighted important differences in the conservatism of exposure 
      scenarios, the derivation of point of departures and the subsequent acceptable 
      MOEs between the silos. To overarch the risk despite these differences, a nMOET 
      approach can be used.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Sprong, Corinne
AU  - Sprong C
AD  - RIVM, National Institute for Public Health and the Environment, PO Box 1, 3720 
      BA, Bilthoven, the Netherlands. Electronic address: corinne.sprong@rivm.nl.
FAU - Crepet, Amelie
AU  - Crepet A
AD  - ANSES, French Agency for Food, Environmental and Occupational Health and Safety, 
      Risk Assessment Department, Methodology and Studies Unit, 947001, Maisons-Alfort, 
      France.
FAU - Metruccio, Francesca
AU  - Metruccio F
AD  - ICPS, International Centre for PPRs and Health Risk Prevention, ASST 
      Fatebenefratelli Sacco, Ospedale L. Sacco Via GB Grassi 74, 20157, Milano, Italy.
FAU - Blaznik, Urska
AU  - Blaznik U
AD  - National Institute of Public Health, Environmental Health Centre, Trubarjeva 2, 
      Ljubljana, Slovenia.
FAU - Anagnostopoulos, Chris
AU  - Anagnostopoulos C
AD  - Benaki Phytopathological Institute, Department of Pesticide Control and 
      Phytopharmacy, Laboratory of Pesticide Residues, 8 Stefanou Delta Street, 
      Kifissia, Athens, 14561, Greece.
FAU - Christodoulou, Despo Louca
AU  - Christodoulou DL
AD  - State General Laboratory, Ministry of Health, Nicosia, Cyprus.
FAU - Jensen, Bodil Hamborg
AU  - Jensen BH
AD  - Technical University of Denmark, National Food Institute, Division of Risk 
      Assessment and Nutrition, Kemitorvet, Building 201, DK 2800, Lyngby, Denmark.
FAU - Kennedy, Marc
AU  - Kennedy M
AD  - Fera Science Ltd, Sand Hutton, York, YO41 1LZ, United Kingdom.
FAU - Gonzalez, Neus
AU  - Gonzalez N
AD  - Laboratory of Toxicology and Environmental Health, School of Medecine, IISPV, 
      Universitat Rovira I Virgili, Reus, Catalonia, Spain.
FAU - Rehurkova, Irena
AU  - Rehurkova I
AD  - National Institute of Public Health in Prague, Centre for Health, Nutrition and 
      Food, Brno, Czech Republic.
FAU - Ruprich, Jiri
AU  - Ruprich J
AD  - National Institute of Public Health in Prague, Centre for Health, Nutrition and 
      Food, Brno, Czech Republic.
FAU - Te Biesebeek, Jan Dirk
AU  - Te Biesebeek JD
AD  - RIVM, National Institute for Public Health and the Environment, PO Box 1, 3720 
      BA, Bilthoven, the Netherlands.
FAU - Vanacker, Marie
AU  - Vanacker M
AD  - ANSES, French Agency for Food, Environmental and Occupational Health and Safety, 
      Risk Assessment Department, Methodology and Studies Unit, 947001, Maisons-Alfort, 
      France.
FAU - Moretto, Angelo
AU  - Moretto A
AD  - ICPS, International Centre for PPRs and Health Risk Prevention, ASST 
      Fatebenefratelli Sacco, Ospedale L. Sacco Via GB Grassi 74, 20157, Milano, Italy; 
      Department of Biomedical and Clinical Sciences, Universita Degli Studi di Milano, 
      Milan, Italy.
FAU - van Klaveren, Jacob
AU  - van Klaveren J
AD  - RIVM, National Institute for Public Health and the Environment, PO Box 1, 3720 
      BA, Bilthoven, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20200518
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Child
MH  - *Dietary Exposure
MH  - Environmental Pollutants/toxicity
MH  - Europe
MH  - Humans
MH  - Risk Assessment
OTO - NOTNLM
OT  - Chemical mixtures
OT  - Cumulative risk assessment
OT  - Dietary exposure
OT  - Food additives
OT  - Margin of exposure
OT  - Persistent organic pollutants
OT  - Pesticides
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/05/23 06:00
MHDA- 2021/03/30 06:00
CRDT- 2020/05/23 06:00
PHST- 2020/02/26 00:00 [received]
PHST- 2020/04/24 00:00 [revised]
PHST- 2020/05/04 00:00 [accepted]
PHST- 2020/05/23 06:00 [pubmed]
PHST- 2021/03/30 06:00 [medline]
PHST- 2020/05/23 06:00 [entrez]
AID - S0278-6915(20)30306-9 [pii]
AID - 10.1016/j.fct.2020.111416 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2020 Aug;142:111416. doi: 10.1016/j.fct.2020.111416. Epub 2020 
      May 18.