PMID- 32440494
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 2214-031X (Print)
IS  - 2214-0328 (Electronic)
IS  - 2214-031X (Linking)
VI  - 22
DP  - 2020 May
TI  - The efficacy and safety of denosumab in postmenopausal women with osteoporosis 
      previously treated with bisphosphonates: A review.
PG  - 7-13
LID - 10.1016/j.jot.2019.08.004 [doi]
AB  - OBJECTIVE: The objective of this study was to assess the efficacy and safety of 
      denosumab therapy in osteoporotic postmenopausal women who were previously 
      treated with bisphosphonates. METHODS: Meta-analyses of four available randomised 
      controlled trials that compared osteoporotic patients who switched to denosumab 
      from bisphosphonates (n ​= ​1416) and those who continued bisphosphonates therapy 
      (n ​= ​1411) were included. RESULTS: The increase in bone mineral density (BMD) 
      of both the spine and hip was significantly higher in patients who shifted to 
      denosumab than in those who continued bisphosphonates. Despite the incidence of 
      adverse events (AEs) and fractures being comparable, treatment withdrawal owing 
      to AEs was significantly less frequent in the denosumab group. CONCLUSION: The 
      outcomes and treatment compliance were improved in postmenopausal osteoporotic 
      women who shifted to denosumab from bisphosphonates. THE TRANSLATIONAL POTENTIAL 
      OF THIS ARTICLE: The replacement of bisphosphonates with denosumab may lead to 
      better therapeutic efficacy and fewer adherence barriers ​than those with 
      continued usage of bisphosphonates, which in the future may guide the choice of 
      drug therapy in clinics.
CI  - (c) 2019 The Authors.
FAU - Zhu, Yilin
AU  - Zhu Y
AD  - Department of Orthopaedics, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong, China.
FAU - Huang, Zhonglian
AU  - Huang Z
AD  - Department of Orthopaedics, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Beijing, 
      100035, China.
FAU - Xu, Weicai
AU  - Xu W
AD  - Department of Orthopaedics, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong, China.
FAU - Chen, Hongjiang
AU  - Chen H
AD  - Department of Orthopaedics, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong, China.
FAU - Xu, Jiankun
AU  - Xu J
AD  - Department of Orthopaedics, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong, China.
AD  - Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese 
      University of Hong Kong, China.
FAU - Luo, Shaowei
AU  - Luo S
AD  - Department of Orthopaedics, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong, China.
FAU - Zhang, Yuantao
AU  - Zhang Y
AD  - Department of Orthopaedics, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong, China.
FAU - Zhao, Di
AU  - Zhao D
AD  - Department of Orthopaedics, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong, China.
FAU - Hu, Jun
AU  - Hu J
AD  - Department of Orthopaedics, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190909
PL  - Singapore
TA  - J Orthop Translat
JT  - Journal of orthopaedic translation
JID - 101625127
PMC - PMC7231967
OTO - NOTNLM
OT  - Bisphosphonate
OT  - Denosumab
OT  - Meta-analysis
OT  - Osteoporosis
OT  - Postmenopausal osteoporosis
OT  - Randomised controlled trial
EDAT- 2020/05/23 06:00
MHDA- 2020/05/23 06:01
PMCR- 2019/09/09
CRDT- 2020/05/23 06:00
PHST- 2019/04/07 00:00 [received]
PHST- 2019/07/31 00:00 [revised]
PHST- 2019/08/12 00:00 [accepted]
PHST- 2020/05/23 06:00 [entrez]
PHST- 2020/05/23 06:00 [pubmed]
PHST- 2020/05/23 06:01 [medline]
PHST- 2019/09/09 00:00 [pmc-release]
AID - S2214-031X(19)30200-1 [pii]
AID - 10.1016/j.jot.2019.08.004 [doi]
PST - epublish
SO  - J Orthop Translat. 2019 Sep 9;22:7-13. doi: 10.1016/j.jot.2019.08.004. 
      eCollection 2020 May.