PMID- 32441020
OWN - NLM
STAT- MEDLINE
DCOM- 20210219
LR  - 20210522
IS  - 1920-7476 (Electronic)
IS  - 0008-4263 (Print)
IS  - 0008-4263 (Linking)
VI  - 111
IP  - 3
DP  - 2020 Jun
TI  - Associations of prenatal urinary phthalate exposure with preterm birth: the 
      Maternal-Infant Research on Environmental Chemicals (MIREC) Study.
PG  - 333-341
LID - 10.17269/s41997-020-00322-5 [doi]
AB  - OBJECTIVES: To examine the relation between prenatal urinary phthalate metabolite 
      concentrations and preterm birth (PTB). METHODS: The data were drawn from the 
      Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a pan-Canadian 
      cohort of 1857 pregnant women enrolled between 2008 and 2011. We quantified 
      urinary concentrations of 7 phthalate metabolites that were detected in > 70% of 
      urine samples collected during the first trimester. Gestational age was obtained 
      from either the last menstrual period or early ultrasound. We used Cox 
      proportional hazard models to examine the associations of urinary phthalate 
      metabolite concentrations, plus the molar sum of di-2-ethylhexyl phthalate 
      metabolites ( summation operatorDEHP), with time to delivery before 37 weeks of gestation. We also 
      examined PTB by clinical presentation. PTBs presented with either spontaneous 
      labour or premature rupture of the membrane were considered spontaneous PTB 
      (sPTB). Additionally, we used multiple linear regression to model changes in mean 
      gestational age in relation to phthalate exposure. RESULTS: We found no evidence 
      of an association between first trimester phthalate metabolite concentrations and 
      PTB among the MIREC study participants. For example, each 2-fold increase in any 
      of the 7 phthalate concentrations or  summation operatorDEHP was associated with hazard ratios 
      (HRs) for PTB ranging from 0.95 to 1.07 with 95% confidence intervals including 
      the null. An assessment of non-linear trends showed some evidence of 
      non-monotonic dose-response relationships between phthalates and PTB. 
      Furthermore, male infants exposed to MCPP showed higher sPTB risk compared with 
      female infants. CONCLUSION: Phthalate exposure during early pregnancy is not 
      clearly associated with the risk of PTB among this Canadian population.
FAU - Hu, Janice M Y
AU  - Hu JMY
AD  - Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, 
      Burnaby, BC, V5A 1S6, Canada.
FAU - Arbuckle, Tye E
AU  - Arbuckle TE
AD  - Population Studies Division, Environmental Health Science and Research Bureau, 
      Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Canada.
FAU - Janssen, Patricia
AU  - Janssen P
AD  - School of Population and Public Health, University of British Columbia, 
      Vancouver, BC, V6T 1Z4, Canada.
FAU - Lanphear, Bruce P
AU  - Lanphear BP
AD  - Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, 
      Burnaby, BC, V5A 1S6, Canada.
FAU - Braun, Joseph M
AU  - Braun JM
AD  - Department of Epidemiology, Brown University, Providence, RI, USA.
FAU - Platt, Robert W
AU  - Platt RW
AD  - Department of Epidemiology, Biostatistics and Occupational Health, McGill 
      University, Montreal, Canada.
FAU - Chen, Aimin
AU  - Chen A
AD  - Department of Environmental Health, University of Cincinnati, Cincinnati, OH, 
      45221, USA.
FAU - Fraser, William D
AU  - Fraser WD
AD  - Department d'obstetrique et gynecologie, Universite de Sherbrooke, Quebec, 
      Canada.
FAU - McCandless, Lawrence C
AU  - McCandless LC
AD  - Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, 
      Burnaby, BC, V5A 1S6, Canada. lmccandl@sfu.ca.
LA  - eng
GR  - L-CIP-150736/CIHR/Canada
GR  - MOP-81285/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200521
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
RN  - 0 (Phthalic Acids)
RN  - 6O7F7IX66E (phthalic acid)
SB  - IM
MH  - Adult
MH  - Canada/epidemiology
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Phthalic Acids/*toxicity/*urine
MH  - Pregnancy
MH  - Pregnancy Trimester, First/urine
MH  - Premature Birth/*chemically induced/epidemiology
MH  - *Prenatal Exposure Delayed Effects
MH  - Young Adult
PMC - PMC7351891
OTO - NOTNLM
OT  - Environmental chemicals
OT  - Gestational age
OT  - Phthalates
OT  - Preterm birth
COIS- JMB was financially compensated for serving as an expert witness for plaintiffs 
      in litigation related to tobacco smoke exposures.
EDAT- 2020/05/23 06:00
MHDA- 2021/02/20 06:00
PMCR- 2021/05/21
CRDT- 2020/05/23 06:00
PHST- 2019/07/11 00:00 [received]
PHST- 2020/04/13 00:00 [accepted]
PHST- 2020/05/23 06:00 [pubmed]
PHST- 2021/02/20 06:00 [medline]
PHST- 2020/05/23 06:00 [entrez]
PHST- 2021/05/21 00:00 [pmc-release]
AID - 10.17269/s41997-020-00322-5 [pii]
AID - 322 [pii]
AID - 10.17269/s41997-020-00322-5 [doi]
PST - ppublish
SO  - Can J Public Health. 2020 Jun;111(3):333-341. doi: 10.17269/s41997-020-00322-5. 
      Epub 2020 May 21.