PMID- 32441156
OWN - NLM
STAT- MEDLINE
DCOM- 20210112
LR  - 20210112
IS  - 1744-7593 (Electronic)
IS  - 1742-5247 (Linking)
VI  - 17
IP  - 7
DP  - 2020 Jul
TI  - Self-assembled block polymer aggregates in selective solution: controllable 
      morphology transitions and their applications in drug delivery.
PG  - 947-961
LID - 10.1080/17425247.2020.1767582 [doi]
AB  - INTRODUCTION: Amphiphilic block copolymers are able to self-assemble into rich 
      morphologies with high controllability for drug delivery. Great efforts have been 
      made for decades to construct efficient drug delivery systems (DDSs) using 
      nanostructured self-assemblies to overcome the drawbacks of pharmaceuticals, such 
      as low aqueous solubility, premature drug release during circulation, and 
      undesirable side effects. AREAS COVERED: Here we review the researches of 
      self-assembled block polymer aggregates with a focus on the shape-forming and 
      shape-changing mechanisms, and applications of controlling morphology transition 
      by multiple factors in drug delivery. We tend to provide a comprehensive 
      description of the connection between structure-changing thermodynamics, 
      kinetics, and influencing factors, thus to enlighten more pathways for future 
      developments in the field of drug delivery. EXPERT OPINION: By understanding the 
      underlying mechanisms for the structure formation and transition, it enables 
      versatile applications in DDSs design by altering drug morphologies. However, 
      developing more sophisticated and multifunctional polymeric nanocarriers is still 
      challengeable in the clinical application, which would hold considerable 
      potential in promoting the efficiency in morphology control to achieve higher 
      intelligence of drug delivery.
FAU - Jiao, Weiqi
AU  - Jiao W
AD  - Department of Pharmaceutics, China Pharmaceutical University , Nanjing, PR China.
AD  - Department of Biochemistry and Biology, Johns Hopkins Bloomberg School of Public 
      Health , Baltimore, MD, US.
FAU - Yang, Hu
AU  - Yang H
AUID- ORCID: 0000-0003-3030-004X
AD  - Department of Chemical and Life Science Engineering, Virginia Commonwealth 
      University , Richmond, VA, United States.
FAU - Wu, Zimei
AU  - Wu Z
AUID- ORCID: 0000-0001-9777-0674
AD  - School of Pharmacy, University of Auckland , Auckland, New Zealand.
FAU - Liu, Jianping
AU  - Liu J
AUID- ORCID: 0000-0003-1825-7122
AD  - Department of Pharmaceutics, China Pharmaceutical University , Nanjing, PR China.
FAU - Zhang, Wenli
AU  - Zhang W
AUID- ORCID: 0000-0001-8121-8244
AD  - Department of Pharmaceutics, China Pharmaceutical University , Nanjing, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200522
PL  - England
TA  - Expert Opin Drug Deliv
JT  - Expert opinion on drug delivery
JID - 101228421
RN  - 0 (Micelles)
RN  - 0 (Polymers)
SB  - IM
MH  - *Drug Delivery Systems
MH  - Micelles
MH  - *Nanostructures
MH  - Polymers/*chemistry
MH  - Solubility
OTO - NOTNLM
OT  - Drug delivery
OT  - block copolymers
OT  - morphology transition
OT  - self-assembly
EDAT- 2020/05/23 06:00
MHDA- 2021/01/13 06:00
CRDT- 2020/05/23 06:00
PHST- 2020/05/23 06:00 [pubmed]
PHST- 2021/01/13 06:00 [medline]
PHST- 2020/05/23 06:00 [entrez]
AID - 10.1080/17425247.2020.1767582 [doi]
PST - ppublish
SO  - Expert Opin Drug Deliv. 2020 Jul;17(7):947-961. doi: 
      10.1080/17425247.2020.1767582. Epub 2020 May 22.