PMID- 32442231
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20200909
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 5
DP  - 2020
TI  - Assessment of oxidative stress in autism spectrum disorder using reactive oxygen 
      metabolites and biological antioxidant potential.
PG  - e0233550
LID - 10.1371/journal.pone.0233550 [doi]
LID - e0233550
AB  - There are several studies on oxidative stress of Autism Spectrum Disorder (ASD), 
      but in these cases there is no study to measure oxidative stress and antioxidant 
      capacity at the same time or studies considering childhood development. 
      Therefore, this study comprehensively assessed the level of oxidative stress in 
      ASD children by simultaneously measuring reactive oxygen metabolites (d-ROMs) and 
      biological antioxidant potential (BAP). The subjects were Japanese, 77 typical 
      development (TD) children, 98 ASD children, samples were plasma. The subjects 
      were divided into age groups: toddlers/preschool age (2-6 years) and school age 
      (7-15 years), to compare the relationships among the d-ROMs levels and BAP/d-ROMs 
      ratios. Furthermore, the correlations between the Parent-interview ASD Rating 
      Scales (PARS) scores and the measured values were analyzed. The levels of d-ROMs 
      were significantly higher in the ASD (7-15 years) than in TD (7-15 years). The 
      PARS scores were significantly higher in the ASD and were significantly 
      correlated with d-ROMs levels. These results suggested that d-ROMs and BAP/d-ROMs 
      ratios could be objective, measured indicators that could be used in clinical 
      practice to assess stress in ASD children.
FAU - Morimoto, Masahito
AU  - Morimoto M
AUID- ORCID: 0000-0003-0358-1966
AD  - Department of pharmacy, Japanese Red Cross Tokushima Hinomine Rehabilitation 
      Center for People with Disabilities, Tokushima, Japan.
FAU - Hashimoto, Toshiaki
AU  - Hashimoto T
AD  - Department of pediatrics, Japanese Red Cross Tokushima Hinomine Rehabilitation 
      Center for People with Disabilities, Tokushima, Japan.
FAU - Tsuda, Yoshimi
AU  - Tsuda Y
AD  - Department of pediatrics, Japanese Red Cross Tokushima Hinomine Rehabilitation 
      Center for People with Disabilities, Tokushima, Japan.
FAU - Nakatsu, Tadanori
AU  - Nakatsu T
AD  - Department of pediatrics, Japanese Red Cross Tokushima Hinomine Rehabilitation 
      Center for People with Disabilities, Tokushima, Japan.
FAU - Kitaoka, Taisuke
AU  - Kitaoka T
AD  - Graduate School of Pharmaceutical Sciences, Tokushima Bunri University, 
      Tokushima, Japan.
FAU - Kyotani, Shojiro
AU  - Kyotani S
AD  - Graduate School of Pharmaceutical Sciences, Tokushima Bunri University, 
      Tokushima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200522
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adolescent
MH  - Autism Spectrum Disorder/*metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/*metabolism
PMC - PMC7244111
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/05/23 06:00
MHDA- 2020/09/10 06:00
PMCR- 2020/05/22
CRDT- 2020/05/23 06:00
PHST- 2019/09/20 00:00 [received]
PHST- 2020/05/07 00:00 [accepted]
PHST- 2020/05/23 06:00 [entrez]
PHST- 2020/05/23 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
PHST- 2020/05/22 00:00 [pmc-release]
AID - PONE-D-19-26530 [pii]
AID - 10.1371/journal.pone.0233550 [doi]
PST - epublish
SO  - PLoS One. 2020 May 22;15(5):e0233550. doi: 10.1371/journal.pone.0233550. 
      eCollection 2020.