PMID- 32444876
OWN - NLM
STAT- MEDLINE
DCOM- 20200803
LR  - 20210110
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 222
IP  - 4
DP  - 2020 Jul 23
TI  - Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact 
      and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice.
PG  - 551-555
LID - 10.1093/infdis/jiaa281 [doi]
AB  - We simulated 3 transmission modes, including close-contact, respiratory droplets 
      and aerosol routes, in the laboratory. Severe acute respiratory syndrome 
      coronavirus 2 (SARS-CoV-2) can be highly transmitted among naive human 
      angiotensin-converting enzyme 2 (hACE2) mice via close contact because 7 of 13 
      naive hACE2 mice were SARS-CoV-2 antibody seropositive 14 days after being 
      introduced into the same cage with 3 infected-hACE2 mice. For respiratory 
      droplets, SARS-CoV-2 antibodies from 3 of 10 naive hACE2 mice showed 
      seropositivity 14 days after introduction into the same cage with 3 
      infected-hACE2 mice, separated by grids. In addition, hACE2 mice cannot be 
      experimentally infected via aerosol inoculation until continued up to 25 minutes 
      with high viral concentrations.
CI  - (c) The Author(s) 2020. Published by Oxford University Press for the Infectious 
      Diseases Society of America.
FAU - Bao, Linlin
AU  - Bao L
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Gao, Hong
AU  - Gao H
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Deng, Wei
AU  - Deng W
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Lv, Qi
AU  - Lv Q
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Yu, Haisheng
AU  - Yu H
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Liu, Mingya
AU  - Liu M
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Yu, Pin
AU  - Yu P
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Liu, Jiangning
AU  - Liu J
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Qu, Yajin
AU  - Qu Y
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Gong, Shuran
AU  - Gong S
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Lin, Kaili
AU  - Lin K
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Qi, Feifei
AU  - Qi F
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Xu, Yanfeng
AU  - Xu Y
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Li, Fengli
AU  - Li F
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Xiao, Chong
AU  - Xiao C
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Xue, Jing
AU  - Xue J
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Song, Zhiqi
AU  - Song Z
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Xiang, Zhiguang
AU  - Xiang Z
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Wang, Guanpeng
AU  - Wang G
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Wang, Shunyi
AU  - Wang S
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Liu, Xing
AU  - Liu X
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Zhao, Wenjie
AU  - Zhao W
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Han, Yunlin
AU  - Han Y
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Wei, Qiang
AU  - Wei Q
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
FAU - Qin, Chuan
AU  - Qin C
AD  - NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory 
      for Animal Models of Emerging and Remerging Infectious Diseases, Institute of 
      Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative 
      Medicine Center, Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Aerosols)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (RNA, Viral)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
RN  - EC 3.4.17.23 (ACE2 protein, human)
RN  - EC 3.4.17.23 (Ace2 protein, mouse)
RN  - EC 3.4.17.23 (Angiotensin-Converting Enzyme 2)
SB  - IM
MH  - Aerosols
MH  - Anal Canal/virology
MH  - Angiotensin-Converting Enzyme 2
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - *Betacoronavirus/genetics/immunology/isolation & purification
MH  - COVID-19
MH  - Chlorocebus aethiops
MH  - Coronavirus Infections/*transmission
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Lung/pathology/virology
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Pandemics
MH  - Peptidyl-Dipeptidase A/genetics
MH  - Pharynx/virology
MH  - Pneumonia, Viral/*transmission
MH  - RNA, Viral/isolation & purification
MH  - Respiratory System/virology
MH  - Risk
MH  - SARS-CoV-2
MH  - Specific Pathogen-Free Organisms
MH  - Time Factors
MH  - Vero Cells
MH  - Viral Load
MH  - Weight Loss
PMC - PMC7313959
OTO - NOTNLM
OT  - SARS-COV-2
OT  - aerosol
OT  - close contact
OT  - hACE2 transgenic mice
OT  - respiratory droplets
OT  - transmission routes
EDAT- 2020/05/24 06:00
MHDA- 2020/08/04 06:00
PMCR- 2020/05/23
CRDT- 2020/05/24 06:00
PHST- 2020/03/29 00:00 [received]
PHST- 2020/05/21 00:00 [accepted]
PHST- 2020/05/24 06:00 [pubmed]
PHST- 2020/08/04 06:00 [medline]
PHST- 2020/05/24 06:00 [entrez]
PHST- 2020/05/23 00:00 [pmc-release]
AID - 5842264 [pii]
AID - jiaa281 [pii]
AID - 10.1093/infdis/jiaa281 [doi]
PST - ppublish
SO  - J Infect Dis. 2020 Jul 23;222(4):551-555. doi: 10.1093/infdis/jiaa281.