PMID- 32445019
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 27
IP  - 1
DP  - 2021 Jan
TI  - Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic 
      Stress Disorder.
PG  - 39-46
LID - 10.1007/s11655-020-2724-4 [doi]
AB  - OBJECTIVE: Post-traumatic stress disorder (PTSD) is a psychiatric disorder 
      characterized by depression and anxiety, that arises due to an imbalance of 
      neurotransmitters in response to excessive stress. Hesperidin (HSD) is a 
      naturally occurring flavonoid shown to exert a variety of biological activities, 
      including antioxidant, anti-inflammatory, and neuroprotective effects. METHODS: 
      This study was used the open field test (OFT) and forced swimming test (FST) to 
      examine the effects of HSD on the depression-like response of rats after exposure 
      to a single prolonged stress (SPS) leading to the dysregulation of the 
      serotonergic activation system. Male rats were given HSD (20, 50, and 100 mg/kg, 
      intraperitoneal injection, n=6-7 per group) once daily for 14 days after exposure 
      to SPS. The influence of administration of HSD on SPS-induced behavioral 
      responses and concentrations of serotonin (5-HT), 5-hydroxyindoleacetic acid 
      (5-HIAA), and monoamine oxidase-A (MAO-A) in the rat brain were also investigated 
      using enzyme-linked immunoassays (ELISAs). RESULTS: Daily HSD administration 
      signifificantly improved depression-like behaviors in the FST (P0.05), increased 
      the number of lines crossed in the central zone of the OFT (P0.01), and reduced 
      freezing behavior both in contextual and cued fear conditioning. HSD treatment 
      also attenuated the reduction in SPS-induced 5-HT concentrations in the 
      hippocampus and amygdala. This increase in 5-HT concentrations during HSD 
      treatment was partially attributed to a decrease in the 5-HIAA/5-HT ratio in the 
      hippocampus of rats with PTSD. Furthermore, HSD treatment inhibited activity of 
      MAO-A and decreases of tryptophan hydroxylase-1 expression in the hippocampus. 
      CONCLUSION: HSD was shown to exert antidepressant effects in rats exposed to SPS, 
      suggesting that this natural flflavonoid may be an effective medicine for PTSD.
FAU - Lee, Bombi
AU  - Lee B
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul, 02447, Republic of Korea. bombi@khu.ac.kr.
AD  - Center for Converging Humanities, Kyung Hee University, Seoul, 02447, Republic of 
      Korea. bombi@khu.ac.kr.
FAU - Choi, Gwang Muk
AU  - Choi GM
AD  - The Graduate School of Basic Science of Medicine, College of Medicine, Kyung Hee 
      University, Seoul, 02447, Republic of Korea.
FAU - Sur, Bongjun
AU  - Sur B
AD  - Department of Molecular Medicine and TIDRC, School of Medicine, Ewha Womans 
      University, Seoul, 07985, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20200522
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
RN  - 0 (Antidepressive Agents)
RN  - E750O06Y6O (Hesperidin)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology/therapeutic use
MH  - Behavior, Animal
MH  - Disease Models, Animal
MH  - Hesperidin/pharmacology/therapeutic use
MH  - Hippocampus
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Stress Disorders, Post-Traumatic/drug therapy
OTO - NOTNLM
OT  - depression
OT  - hesperidin
OT  - post-traumatic stress disorder
OT  - serotonin
EDAT- 2020/05/24 06:00
MHDA- 2021/11/09 06:00
CRDT- 2020/05/24 06:00
PHST- 2019/11/14 00:00 [accepted]
PHST- 2020/05/24 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
PHST- 2020/05/24 06:00 [entrez]
AID - 10.1007/s11655-020-2724-4 [pii]
AID - 10.1007/s11655-020-2724-4 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2021 Jan;27(1):39-46. doi: 10.1007/s11655-020-2724-4. Epub 
      2020 May 22.