PMID- 32445942
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20220531
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 187
DP  - 2020 Aug
TI  - Environmental exposures and breast cancer risk in the context of underlying 
      susceptibility: A systematic review of the epidemiological literature.
PG  - 109346
LID - S0013-9351(20)30239-5 [pii]
LID - 10.1016/j.envres.2020.109346 [doi]
AB  - BACKGROUND: The evidence evaluating environmental chemical exposures (ECE) and 
      breast cancer (BC) risk is heterogeneous which may stem in part as few studies 
      measure ECE during key BC windows of susceptibility (WOS). Another possibility 
      may be that most BC studies are skewed towards individuals at average risk, which 
      may limit the ability to detect signals from ECE. OBJECTIVES: We reviewed the 
      literature on ECE and BC focusing on three types of studies or subgroup analyses 
      based on higher absolute BC risk: BC family history (Type 1); early onset BC 
      (Type 2); and/or genetic susceptibility (Type 3). METHODS: We systematically 
      searched the PubMed database to identify epidemiologic studies examining ECE and 
      BC risk published through June 1, 2019. RESULTS: We identified 100 publications 
      in 56 unique epidemiologic studies. Of these 56 studies, only 2 (3.6%) were 
      enriched with BC family history and only 11% of studies (6/56) were specifically 
      enriched with early onset cases. 80% of the publications from these 8 enriched 
      studies (Type 1: 8/10 publications; Type 2: 8/10 publications) supported a 
      statistically significant association between ECE and BC risk including studies 
      of PAH, indoor cooking, NO(2), DDT; PCBs, PFOSA; metals; personal care products; 
      and occupational exposure to industrial dyes. 74% of Type 3 publications (20/27) 
      supported statistically significant associations for PAHs, traffic-related air 
      pollution, PCBs, phthalates, and PFOSAs in subgroups of women with greater 
      genetic susceptibility due to variants in carcinogen metabolism, DNA repair, 
      oxidative stress, cellular apoptosis and tumor suppressor genes. DISCUSSION: 
      Studies enriched for women at higher BC risk through family history, younger age 
      of onset and/or genetic susceptibility consistently support an association 
      between an ECE and BC risk. In addition to measuring exposures during WOS, 
      designing studies that are enriched with women at higher absolute risk are 
      necessary to robustly measure the role of ECE on BC risk.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Zeinomar, Nur
AU  - Zeinomar N
AD  - Department of Epidemiology, Mailman School of Public Health, Columbia University, 
      New York, NY, USA.
FAU - Oskar, Sabine
AU  - Oskar S
AD  - Department of Epidemiology, Mailman School of Public Health, Columbia University, 
      New York, NY, USA.
FAU - Kehm, Rebecca D
AU  - Kehm RD
AD  - Department of Epidemiology, Mailman School of Public Health, Columbia University, 
      New York, NY, USA.
FAU - Sahebzeda, Shamin
AU  - Sahebzeda S
AD  - Department of Epidemiology, Mailman School of Public Health, Columbia University, 
      New York, NY, USA.
FAU - Terry, Mary Beth
AU  - Terry MB
AD  - Department of Epidemiology, Mailman School of Public Health, Columbia University, 
      New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia 
      University Irving Medical Center, New York, NY, USA. Electronic address: 
      mt146@cumc.columbia.edu.
LA  - eng
GR  - T32 CA009529/CA/NCI NIH HHS/United States
GR  - TL1 TR001875/TR/NCATS NIH HHS/United States
GR  - U01 ES026122/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20200312
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - *Breast Neoplasms/chemically induced/epidemiology
MH  - Cooking
MH  - *Environmental Exposure
MH  - *Environmental Pollutants/toxicity
MH  - Female
MH  - Humans
MH  - Polychlorinated Biphenyls
MH  - Polycyclic Aromatic Hydrocarbons
PMC - PMC7314105
MID - NIHMS1596648
OTO - NOTNLM
OT  - Breast cancer
OT  - Early onset breast cancer
OT  - Environmental contaminants
OT  - Family history
OT  - Gene-environment interaction
COIS- Declaration of competing interests The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/05/24 06:00
MHDA- 2020/11/21 06:00
PMCR- 2021/08/01
CRDT- 2020/05/24 06:00
PHST- 2019/09/10 00:00 [received]
PHST- 2020/03/02 00:00 [revised]
PHST- 2020/03/02 00:00 [accepted]
PHST- 2020/05/24 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2020/05/24 06:00 [entrez]
PHST- 2021/08/01 00:00 [pmc-release]
AID - S0013-9351(20)30239-5 [pii]
AID - 10.1016/j.envres.2020.109346 [doi]
PST - ppublish
SO  - Environ Res. 2020 Aug;187:109346. doi: 10.1016/j.envres.2020.109346. Epub 2020 
      Mar 12.