PMID- 32447248 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 2211-0356 (Electronic) IS - 2211-0348 (Linking) VI - 43 DP - 2020 Aug TI - Brain MRI features of Chinese Han patients with MOG-antibody disease. PG - 102167 LID - S2211-0348(20)30243-1 [pii] LID - 10.1016/j.msard.2020.102167 [doi] AB - Background The spectrum of imaging features of patients with MOG antibody disease (MOGAD) remains unclear. We aimed to determine the brain MRI features of MOGAD in a Chinese Han cohort and to assess differences in brain MRI features between MOGAD and neuromyelitis optica spectrum disorders (NMOSDs). Methods We retrospectively reviewed the MRI images of 43 patients with MOGAD. As a routine diagnostic approach, all patients underwent serum aquaporin 4 IgG (AQP4-IgG) and MOG-IgG detection via cell-based assays. The topographies and features of brain lesions were independently assessed by two raters. As a comparison, topographies and features of brain lesions were also assessed using neuroimaging characteristics of NMOSDs recommended by the international panel for NMO diagnosis (IPND) in 2015. Results Thirty-five (81.4%) patients were found to have brain lesions. These brain lesions were classified into the following three patterns according to their distributions: (I) lesions involving midline structures and deep gray matte; (II) supratentorial white matter lesions; and (III) cortical gray matter lesions. There were 17 patients whose brain lesions did not fulfill the neuroimaging characteristics of NMOSDs recommended by the 2015 IPND, in which 11 patients had cortical gray matter lesions and/or juxtacortical white matter lesions, four patients had middle cerebral peduncles lesions, and two patients had gray matter lesions and juxtacortical white matter lesions, as well as middle cerebral peduncles lesions. Conclusion MOGAD in this Chinese Han cohort exhibited distinct brain MRI features, especially in terms of cortical gray matter lesions, juxtacortical white matter lesions, and middle cerebral peduncles lesions, which may help to further identify and diagnose patients with MOGAD while they are waiting for serological antibody results. CI - Copyright (c) 2020 Elsevier B.V. All rights reserved. FAU - Li, Haiqing AU - Li H AD - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China. FAU - Yang, Liqin AU - Yang L AD - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China; Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China. FAU - Wu, Zhengyu AU - Wu Z AD - Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai, China. FAU - Zhou, Lei AU - Zhou L AD - Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China. FAU - Bao, Yifang AU - Bao Y AD - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China. FAU - Geng, Daoying AU - Geng D AD - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China; Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China. FAU - Quan, Chao AU - Quan C AD - Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: chao_quan@fudan.edu.cn. FAU - Li, Yuxin AU - Li Y AD - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China; Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China. Electronic address: liyuxin@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20200515 PL - Netherlands TA - Mult Scler Relat Disord JT - Multiple sclerosis and related disorders JID - 101580247 RN - 0 (Aquaporin 4) RN - 0 (Autoantibodies) RN - 0 (Myelin-Oligodendrocyte Glycoprotein) SB - IM MH - Aquaporin 4 MH - *Autoantibodies MH - Brain/diagnostic imaging MH - China MH - Humans MH - Magnetic Resonance Imaging MH - Myelin-Oligodendrocyte Glycoprotein MH - Neuroimaging MH - *Neuromyelitis Optica/diagnostic imaging MH - Retrospective Studies OTO - NOTNLM OT - Magnetic resonance imaging OT - Myelin oligodendrocyte glycoprotein antibody OT - Neuromyelitis optica spectrum disorders COIS- Declarations of Competing Interest None EDAT- 2020/05/25 06:00 MHDA- 2021/05/15 06:00 CRDT- 2020/05/25 06:00 PHST- 2020/03/09 00:00 [received] PHST- 2020/04/15 00:00 [revised] PHST- 2020/04/27 00:00 [accepted] PHST- 2020/05/25 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2020/05/25 06:00 [entrez] AID - S2211-0348(20)30243-1 [pii] AID - 10.1016/j.msard.2020.102167 [doi] PST - ppublish SO - Mult Scler Relat Disord. 2020 Aug;43:102167. doi: 10.1016/j.msard.2020.102167. Epub 2020 May 15.