PMID- 32447519
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 27
IP  - 1
DP  - 2021 Jan
TI  - Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic 
      Stroke Treatment via a Network Pharmacology Approach.
PG  - 62-69
LID - 10.1007/s11655-020-2716-4 [doi]
AB  - OBJECTIVE: To investigate the shared mechanisms of scutellarin in angina pectoris 
      (AP) and ischemic stroke (IS) treatment. METHODS: A network pharmacology approach 
      was used to detect the potential mechanisms of scutellarin in AP and IS treatment 
      by target prediction, protein-protein interaction (PPI) data collection, network 
      construction, network analysis, and enrichment analysis. Furthermore, molecular 
      docking simulation was employed to analyze the interaction between scutellarin 
      and core targets. RESULTS: Two networks were established, including a 
      disease-target network and a PPI network of scutellarin targets against AP and 
      IS. Network analysis showed that 14 targets, namely, AKT1, VEGFA, JUN, ALB, MTOR, 
      ESR1, MAPK8, HSP90AA1, NOS3, SERPINE1, FGA, F2, FOXO3, and STAT1, might be the 
      therapeutic targets of scutellarin in AP and IS. Among them, NOS3 and F2 were 
      recognized as the core targets. Additionally, molecular docking simulation 
      confifirmed that scutellarin exhibited a relatively high potential for binding to 
      the active sites of NOS3 and F2. Furthermore, enrichment analysis indicated that 
      scutellarin might exert a therapeutic role in both AP and IS by regulating 
      several important pathways, such as coagulation cascades, mitogen-activated 
      protein kinase (MAPK) signaling pathway, phosphatidylinositol 3 kinase 
      (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling 
      pathway, Toll-like receptor signaling pathway, hypoxia inducible factor-1 (HIF-1) 
      signaling pathway, forkhead box O (FoxO) signaling pathway, tumor necrosis factor 
      (TNF) signaling pathway, adipocytokine signaling pathway, insulin signaling 
      pathway, insulin resistance, and estrogen signaling pathway. CONCLUSIONS: The 
      shared underlying mechanisms of scutellarin on AP and IS treatment might be 
      strongly associated with its vasorelaxant, anticoagulant, anti-inflammatory, and 
      antioxidative effects as well as its effect on improving lipid metabolism.
FAU - Meng, Zi-Qi
AU  - Meng ZQ
AD  - Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine, Beijing, 100029, China.
FAU - Wu, Jia-Rui
AU  - Wu JR
AD  - Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine, Beijing, 100029, China. exogamy@163.com.
FAU - Zhu, Ying-Li
AU  - Zhu YL
AD  - Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine, Beijing, 100029, China.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine, Beijing, 100029, China.
FAU - Fu, Chang-Geng
AU  - Fu CG
AD  - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, 
      China.
FAU - Liu, Xin-Kui
AU  - Liu XK
AD  - Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine, Beijing, 100029, China.
FAU - Liu, Shu-Yu
AU  - Liu SY
AD  - Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine, Beijing, 100029, China.
FAU - Ni, Meng-Wei
AU  - Ni MW
AD  - Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine, Beijing, 100029, China.
FAU - Guo, Si-Yu
AU  - Guo SY
AD  - Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine, Beijing, 100029, China.
LA  - eng
PT  - Journal Article
DEP - 20200522
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
RN  - 0 (Glucuronates)
RN  - 16IGP0ML9A (scutellarin)
RN  - 7V515PI7F6 (Apigenin)
SB  - IM
MH  - Angina Pectoris/drug therapy
MH  - Apigenin/*therapeutic use
MH  - *Brain Ischemia
MH  - Glucuronates/*therapeutic use
MH  - Humans
MH  - *Ischemic Stroke/drug therapy
MH  - Molecular Docking Simulation
MH  - Phosphatidylinositol 3-Kinases
OTO - NOTNLM
OT  - angina pectoris
OT  - ischemic stroke
OT  - network pharmacology
OT  - scutellarin
EDAT- 2020/05/25 06:00
MHDA- 2021/11/09 06:00
CRDT- 2020/05/25 06:00
PHST- 2019/08/28 00:00 [accepted]
PHST- 2020/05/25 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
PHST- 2020/05/25 06:00 [entrez]
AID - 10.1007/s11655-020-2716-4 [pii]
AID - 10.1007/s11655-020-2716-4 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2021 Jan;27(1):62-69. doi: 10.1007/s11655-020-2716-4. Epub 
      2020 May 22.