PMID- 32447599
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 39
IP  - 12
DP  - 2020 Dec
TI  - IPAF should receive early treatment for sharing similar clinical characteristics 
      as CTD-ILD: a report from 273 Chinese patients.
PG  - 3817-3823
LID - 10.1007/s10067-020-05149-6 [doi]
AB  - OBJECTIVES: The clinical characteristics of interstitial pneumonia with 
      autoimmune features (IPAF) and connective tissue disease interstitial lung 
      disease (CTD-ILD) have not been adequately compared. We compared the clinical 
      characteristics of these two conditions and analyzed the changes in lung function 
      before and after treatment of IPAF. METHODS: A total of 412 patients were 
      enrolled in the study, and their clinical characteristics were assessed. The 
      treatment-related changes in 12 cases of IPAF were analyzed. RESULTS: Complete 
      clinical data were available for 126 patients with CTD-ILD and 147 with IPAF. All 
      IPAF patients showed autoantibody positivity. The proportion of patients showing 
      extrapulmonary symptoms in the CTD-ILD group was higher than that in the IPAF 
      group (P < 0.05). Patients with IPAF demonstrated lower P(A-a)O(2) and higher 
      PaO(2) and PaCO(2) than those with CTD-ILD (P < 0.05 for all comparisons). Forced 
      vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide 
      (D(LCO)) in IPAF patients were higher than those in CTD-ILD patients (P = 0.023 
      for FVC; P = 0.011 for D(LCO)). Among patients with IPAF, only the proportions of 
      honeycombing and nodules were lower than those in CTD-ILD patients (P < 0.05). 
      Both FVC and D(LCO) values increased after treatment in patients with IPAF 
      (P < 0.05). CONCLUSION: IPAF showed autoantibody positivity and similar computed 
      tomography (CT) findings as CTD-ILD, and lung function in patients with IPAF 
      improved after immunosuppressive treatment, indicating that IPAF should receive 
      attention and early immunosuppressive treatment like CTD-ILD, even though IPAF 
      exhibits no extrapulmonary symptoms. Key Points * Clinical characteristics of 
      IPAF.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Clinical Immunology, Institute of Rheumatism & Immunity, PLA, 
      Branch of Immune Cell Biology, State Key Discipline of Cell Biology, Xijing 
      Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 
      710032, Shaanxi Province, People's Republic of China.
FAU - Zheng, ZhaoHui
AU  - Zheng Z
AD  - Department of Clinical Immunology, Institute of Rheumatism & Immunity, PLA, 
      Branch of Immune Cell Biology, State Key Discipline of Cell Biology, Xijing 
      Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 
      710032, Shaanxi Province, People's Republic of China.
FAU - Han, Qing
AU  - Han Q
AD  - Department of Clinical Immunology, Institute of Rheumatism & Immunity, PLA, 
      Branch of Immune Cell Biology, State Key Discipline of Cell Biology, Xijing 
      Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 
      710032, Shaanxi Province, People's Republic of China.
FAU - Li, ZhiQin
AU  - Li Z
AD  - Department of Clinical Immunology, Institute of Rheumatism & Immunity, PLA, 
      Branch of Immune Cell Biology, State Key Discipline of Cell Biology, Xijing 
      Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 
      710032, Shaanxi Province, People's Republic of China.
FAU - Xie, RongHua
AU  - Xie R
AD  - Department of Clinical Immunology, Institute of Rheumatism & Immunity, PLA, 
      Branch of Immune Cell Biology, State Key Discipline of Cell Biology, Xijing 
      Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 
      710032, Shaanxi Province, People's Republic of China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Department of Clinical Immunology, Institute of Rheumatism & Immunity, PLA, 
      Branch of Immune Cell Biology, State Key Discipline of Cell Biology, Xijing 
      Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 
      710032, Shaanxi Province, People's Republic of China.
FAU - Zhang, Bei
AU  - Zhang B
AD  - Department of Clinical Immunology, Institute of Rheumatism & Immunity, PLA, 
      Branch of Immune Cell Biology, State Key Discipline of Cell Biology, Xijing 
      Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 
      710032, Shaanxi Province, People's Republic of China.
FAU - Zhu, Ping
AU  - Zhu P
AUID- ORCID: 0000-0002-8391-4945
AD  - Department of Clinical Immunology, Institute of Rheumatism & Immunity, PLA, 
      Branch of Immune Cell Biology, State Key Discipline of Cell Biology, Xijing 
      Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 
      710032, Shaanxi Province, People's Republic of China. zhuping@fmmu.edu.cn.
LA  - eng
GR  - 2017YFC0909002/the National Nature Science Foundation Key Research Project of 
      China/
PT  - Journal Article
DEP - 20200523
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
SB  - IM
MH  - China
MH  - Connective Tissue Diseases
MH  - Humans
MH  - Lung/diagnostic imaging
MH  - *Lung Diseases, Interstitial/diagnosis/drug therapy
MH  - Vital Capacity
OTO - NOTNLM
OT  - Clinical characteristics
OT  - Connective tissue disease
OT  - Interstitial lung disease
OT  - Interstitial pneumonia with autoimmune features
EDAT- 2020/05/25 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/05/25 06:00
PHST- 2019/10/08 00:00 [received]
PHST- 2020/05/05 00:00 [accepted]
PHST- 2020/03/22 00:00 [revised]
PHST- 2020/05/25 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/05/25 06:00 [entrez]
AID - 10.1007/s10067-020-05149-6 [pii]
AID - 10.1007/s10067-020-05149-6 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2020 Dec;39(12):3817-3823. doi: 10.1007/s10067-020-05149-6. Epub 
      2020 May 23.