PMID- 32447865
OWN - NLM
STAT- MEDLINE
DCOM- 20210601
LR  - 20210601
IS  - 2448-9190 (Electronic)
IS  - 0002-5151 (Linking)
VI  - 67
IP  - 1
DP  - 2020 Jan-Mar
TI  - [Chronic kidney disease in adults with primary immunodeficiency diseases in 
      treatment with intravenous immunoglobulin].
PG  - 25-33
LID - 10.29262/ram.v67i1.707 [doi]
AB  - BACKGROUND: Intravenous immunoglobulin (IVIG) is the treatment of choice for 
      humoral primary immunodeficiency diseases (PIDs). A third of the patients who 
      receive intravenous immunoglobulin have adverse reactions, such as osmotic 
      nephrosis. OBJECTIVE: To assess the presence of kidney disease in adults with 
      humoral PIDs, in treatment with intravenous immunoglobulin. METHODS: A 
      cross-sectional, descriptive, and observational study of patients who belong to 
      the PID Clinic of the Specialties Hospital of the National Medical Center "Siglo 
      XXI", Mexico City, who receive treatment with intravenous immunoglobulin. A 
      questionnaire with demographic information, 24h urine creatinine clearance, serum 
      creatinine, urea, and BUN (Blood Urea Nitrogen) was applied. RESULTS: 35 patients 
      were surveyed; 65.7 % were women; the average age was 34 years; 51.4 % of the 
      patients presented kidney damage. Those with > 5 years of treatment with 
      intravenous immunoglobulin presented chronic kidney disease (CKD) with more 
      frequency (55.6 %) according to the KDOQI scale. CONCLUSIONS: Chronic kidney 
      disease occurs in 51 % of adult patients with PID who have been treated with 
      intravenous immunoglobulin for more than 5 years; which is why these patients 
      require periodic evaluations of their kidney function, and the use of sugar-free 
      immunoglobulin in order to reduce the risk.
FAU - O'Farrill-Romanillos, Patricia Maria
AU  - O'Farrill-Romanillos PM
AD  - Instituto Mexicano del Seguro Social, Centro Medico Nacional Siglo XXI, Hospital 
      de Especialidades, Servicio de Alergia e Inmunologia Clinica, Ciudad de Mexico, 
      Mexico. patyfritzenwalden@hotmail.com.
FAU - Luna-Mujica, Ramon Fabricio
AU  - Luna-Mujica RF
FAU - Contreras-Garcia, Carlos Eduardo
AU  - Contreras-Garcia CE
FAU - Anda, Juan Carlos
AU  - Anda JC
LA  - spa
PT  - Journal Article
PT  - Observational Study
TT  - Enfermedad renal cronica en adultos con inmunodeficiencias primarias en 
      tratamiento con inmunoglobulina intravenosa.
PL  - Mexico
TA  - Rev Alerg Mex
JT  - Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
JID - 9438824
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/*adverse effects/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Primary Immunodeficiency Diseases/*drug therapy
MH  - Renal Insufficiency, Chronic/*chemically induced
MH  - Young Adult
OTO - NOTNLM
OT  - Chronic renal failure
OT  - Common variable immunodeficiencies
OT  - Humoral immune response
OT  - Intravenous immunoglobulin
EDAT- 2020/05/25 06:00
MHDA- 2021/06/02 06:00
CRDT- 2020/05/25 06:00
PHST- 2020/05/25 06:00 [entrez]
PHST- 2020/05/25 06:00 [pubmed]
PHST- 2021/06/02 06:00 [medline]
AID - 10.29262/ram.v67i1.707 [doi]
PST - ppublish
SO  - Rev Alerg Mex. 2020 Jan-Mar;67(1):25-33. doi: 10.29262/ram.v67i1.707.