PMID- 32448816
OWN - NLM
STAT- MEDLINE
DCOM- 20210305
LR  - 20210305
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 82
IP  - 7
DP  - 2020 Jul 10
TI  - Studies on heterologous protection between Japanese type 1 and type 2 porcine 
      reproductive and respiratory syndrome virus isolates.
PG  - 935-942
LID - 10.1292/jvms.20-0122 [doi]
AB  - The objective of the present study was to evaluate the cross-protective immunity 
      between type 1 and type 2 porcine reproductive and respiratory syndrome virus 
      (PRRSV) isolates in growing pigs. Japanese type 1 PRRSV, first isolated from a 
      pig with respiratory disorders in a farm in 2009, exhibits unique genetic 
      characteristics. The pathogenicity of a Japanese standard strain of type 2 PRRSV, 
      EDRD1, in pigs immunized by the type 1 PRRSV isolate, Jpn EU 4-37 was determined 
      by evaluating clinical signs, viremia, antibody response, and pathological 
      lesions. Similarly, we evaluated the pathogenicity of Jpn EU 4-37 in pigs 
      immunized by EDRD1 and compared the cross-protective immunity between these 
      isolates. The EDRD1 challenge after Jpn EU 4-37 inoculation reduced viral 
      clearance and shedding in pigs, compared to those treated with the EDRD1 single 
      infection. On the other hand, the pathogenicity of Jpn EU 4-37 after EDRD1 
      infection did not differ significantly compared to non-immunized pigs treated 
      with Jpn EU 4-37. Therefore, exposure to Jpn EU 4-37 could not induce enough 
      immunity to reduce the viremia against subsequent infection by type 2 PRRSV. 
      However, the immunity induced by Jpn EU 4-37 infection may play a role in 
      reducing viremia caused by type 2 PRRSV. Moreover, the immunity induced by the 
      EDRD1 and other genetically related viruses, which are broadly distributed in 
      Japan, may not contribute to cross-protection against Jpn EU 4-37 as an emerging 
      virus.
FAU - Iseki, Hiroshi
AU  - Iseki H
AD  - Division of Viral Disease and Epidemiology, National Institute of Animal Health, 
      National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, 
      Ibaraki 305-0856, Japan.
FAU - Kawashima, Kenji
AU  - Kawashima K
AD  - Division of Viral Disease and Epidemiology, National Institute of Animal Health, 
      National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, 
      Ibaraki 305-0856, Japan.
FAU - Takagi, Michihiro
AU  - Takagi M
AD  - Division of Viral Disease and Epidemiology, National Institute of Animal Health, 
      National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, 
      Ibaraki 305-0856, Japan.
FAU - Shibahara, Tomoyuki
AU  - Shibahara T
AD  - Division of Pathology and Pathophysiology, National Institute of Animal Health, 
      National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, 
      Ibaraki 305-0856, Japan.
AD  - Department of Veterinary Science, Graduate School of Life and Environmental 
      Sciences, Osaka Prefecture University, 1-58 Rinku-oraikita, Izumisano, Osaka 
      598-8531, Japan.
FAU - Mase, Masaji
AU  - Mase M
AD  - Division of Viral Disease and Epidemiology, National Institute of Animal Health, 
      National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, 
      Ibaraki 305-0856, Japan.
AD  - United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, 
      Gifu, Gifu 501-1193, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200522
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Antibodies, Viral)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Administration, Intranasal/veterinary
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/pathology/*virology
MH  - Porcine respiratory and reproductive syndrome 
      virus/genetics/*immunology/pathogenicity
MH  - RNA, Viral
MH  - Specific Pathogen-Free Organisms
MH  - Sus scrofa
MH  - Swine
MH  - Viral Load/veterinary
MH  - Viremia/blood/veterinary
PMC - PMC7399305
OTO - NOTNLM
OT  - Immunity
OT  - pig
OT  - porcine reproductive and respiratory syndrome virus
COIS- We declare no commercial or associated interests that would represent a conflict 
      of interest in connection with the work submitted.
EDAT- 2020/05/26 06:00
MHDA- 2021/03/06 06:00
PMCR- 2020/07/01
CRDT- 2020/05/26 06:00
PHST- 2020/05/26 06:00 [pubmed]
PHST- 2021/03/06 06:00 [medline]
PHST- 2020/05/26 06:00 [entrez]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 20-0122 [pii]
AID - 10.1292/jvms.20-0122 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2020 Jul 10;82(7):935-942. doi: 10.1292/jvms.20-0122. Epub 2020 
      May 22.