PMID- 32450520
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 23
IP  - 6
DP  - 2020 Jun 26
TI  - Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF.
PG  - 101156
LID - S2589-0042(20)30341-2 [pii]
LID - 10.1016/j.isci.2020.101156 [doi]
LID - 101156
AB  - The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under 
      physiological conditions (PBS), biocompatible (to human skin cells), and an 
      efficient drug carrier for the long-term controlled release (through human skin) 
      of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant 
      pharmacological effects of ferulate while enhancing the bio-preservation of 
      dermal skin fibroblasts, during the delivery process. These discoveries pave the 
      way toward the extended use of Sc(III)-based MOFs as drug delivery systems 
      (DDSs).
CI  - Crown Copyright (c) 2020. Published by Elsevier Inc. All rights reserved.
FAU - Osorio-Toribio, Genesis
AU  - Osorio-Toribio G
AD  - Laboratorio de Fisicoquimica y Reactividad de Superficies (LaFReS), Instituto de 
      Investigaciones en Materiales, Universidad Nacional Autonoma de Mexico, Ciudad de 
      Mexico, Mexico.
FAU - Velasquez-Hernandez, Miriam de J
AU  - Velasquez-Hernandez MJ
AD  - Institute of Physical and Theoretical Chemistry, Graz University of Technology, 
      Stremayrgasse 9, 8010 Graz, Austria.
FAU - Mileo, Paulo G M
AU  - Mileo PGM
AD  - ICGM, Univ. Montpellier, CNRS, ENSCM, Montpellier, France.
FAU - Zarate, J Antonio
AU  - Zarate JA
AD  - Laboratorio de Fisicoquimica y Reactividad de Superficies (LaFReS), Instituto de 
      Investigaciones en Materiales, Universidad Nacional Autonoma de Mexico, Ciudad de 
      Mexico, Mexico; ICGM, Univ. Montpellier, CNRS, ENSCM, Montpellier, France.
FAU - Aguila-Rosas, Javier
AU  - Aguila-Rosas J
AD  - Laboratorio de Fisicoquimica y Reactividad de Superficies (LaFReS), Instituto de 
      Investigaciones en Materiales, Universidad Nacional Autonoma de Mexico, Ciudad de 
      Mexico, Mexico; Departamento de Sistemas Biologicos, Universidad Autonoma 
      Metropolitana-Azcapotzalco, Ciudad de Mexico, Mexico.
FAU - Leyva-Gomez, Gerardo
AU  - Leyva-Gomez G
AD  - Departamento de Farmacia, Facultad de Quimica, Universidad Nacional Autonoma de 
      Mexico, Ciudad de Mexico, Mexico.
FAU - Sanchez-Sanchez, Roberto
AU  - Sanchez-Sanchez R
AD  - Unidad de Ingenieria de Tejidos Terapia Celular y Medicina Regenerativa Instituto 
      Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra (INR-LGII), Ciudad de 
      Mexico, Mexico.
FAU - Magana, Jonathan J
AU  - Magana JJ
AD  - Laboratorio de Medicina Genomica, Instituto Nacional de Rehabilitacion Luis 
      Guillermo Ibarra Ibarra (INR-LGII), Ciudad de Mexico, Mexico.
FAU - Perez-Diaz, Mario Alberto
AU  - Perez-Diaz MA
AD  - Laboratorio de Biomembranas, Escuela Nacional de Ciencias Biologicas, Instituto 
      Politecnico Nacional, Ciudad de Mexico, Mexico.
FAU - Lazaro, Isabel Abanades
AU  - Lazaro IA
AD  - Universidad de Valencia (ICMol), Catedratico Jose Beltran-2, Paterna, Spain; 
      WestCHEM School of Chemistry, University of Glasgow, Joseph Black Building, 
      University Avenue, Glasgow G12 8QQ, UK.
FAU - Forgan, Ross S
AU  - Forgan RS
AD  - WestCHEM School of Chemistry, University of Glasgow, Joseph Black Building, 
      University Avenue, Glasgow G12 8QQ, UK.
FAU - Maurin, Guillaume
AU  - Maurin G
AD  - ICGM, Univ. Montpellier, CNRS, ENSCM, Montpellier, France. Electronic address: 
      guillaume.maurin1@umontpellier.fr.
FAU - Lima, Enrique
AU  - Lima E
AD  - Laboratorio de Fisicoquimica y Reactividad de Superficies (LaFReS), Instituto de 
      Investigaciones en Materiales, Universidad Nacional Autonoma de Mexico, Ciudad de 
      Mexico, Mexico. Electronic address: lima@iim.unam.mx.
FAU - Ibarra, Ilich A
AU  - Ibarra IA
AD  - Laboratorio de Fisicoquimica y Reactividad de Superficies (LaFReS), Instituto de 
      Investigaciones en Materiales, Universidad Nacional Autonoma de Mexico, Ciudad de 
      Mexico, Mexico. Electronic address: argel@unam.mx.
LA  - eng
PT  - Journal Article
DEP - 20200511
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC7251947
OTO - NOTNLM
OT  - Chemistry
OT  - Inorganic Chemistry
OT  - Materials Structure
OT  - Medicine
COIS- Declaration of Interests The authors declare no competing interests.
EDAT- 2020/05/26 06:00
MHDA- 2020/05/26 06:01
PMCR- 2020/05/11
CRDT- 2020/05/26 06:00
PHST- 2020/04/01 00:00 [received]
PHST- 2020/04/24 00:00 [revised]
PHST- 2020/05/06 00:00 [accepted]
PHST- 2020/05/26 06:00 [pubmed]
PHST- 2020/05/26 06:01 [medline]
PHST- 2020/05/26 06:00 [entrez]
PHST- 2020/05/11 00:00 [pmc-release]
AID - S2589-0042(20)30341-2 [pii]
AID - 101156 [pii]
AID - 10.1016/j.isci.2020.101156 [doi]
PST - ppublish
SO  - iScience. 2020 Jun 26;23(6):101156. doi: 10.1016/j.isci.2020.101156. Epub 2020 
      May 11.