PMID- 32451277 OWN - NLM STAT- MEDLINE DCOM- 20201109 LR - 20201109 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 30 IP - 8 DP - 2020 Jul 24 TI - Effects of zinc supplementation on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. PG - 1260-1271 LID - S0939-4753(20)30103-4 [pii] LID - 10.1016/j.numecd.2020.03.021 [doi] AB - BACKGROUND AND AIM: Findings on the effects of zinc supplementation on the lipid profile in patients with type 2 diabetes mellitus (T2DM) are conflicting. The current comprehensive systematic review and meta-analysis aimed to summarize available evidence in this regard. METHODS AND RESULTS: After a systematic search in the online databases, we included the randomized controlled trials (RCTs) investigating the effect of zinc supplementation on lipid profile [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)] in patients with T2DM. Altogether, 9 studies with a total sample size of 424 patients with T2DM were included in the analysis. Combining 9 effect sizes from 9 RCTs, we found a significant lowering effect of zinc supplementation on serum levels of TG (weighted mean difference (WMD): -17.08, 95% CI: -30.59, -3.58 mg/dL, P = 0.01) and TC (WMD: -26.16, 95% CI: -49.69, -2.62 mg/dL, P = 0.02). Although the overall effect of zinc supplementation on LDL-C levels was not significant, a beneficial effect was seen in studies that administered <100 mg/d zinc. Based on the non-linear dose-response analysis, a greater reduction in serum levels of TC and LDL-C following zinc supplementation was seen at <12 weeks' duration of intervention. Unlike the overall effect size, we found a significant increasing effect of zinc supplementation on serum HDL-C concentrations in most subgroups of RCTs according to the subgroup analyses. CONCLUSION: We found that zinc supplementation may beneficially influence lipid profile in patients with T2DM. CI - Copyright (c) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. FAU - Asbaghi, Omid AU - Asbaghi O AD - Gerash University of Medical Sciences, Gerash, Iran; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: omid.asbaghi@gmail.com. FAU - Sadeghian, Mehdi AU - Sadeghian M AD - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran. Electronic address: mehdisad69@gmail.com. FAU - Fouladvand, Faezeh AU - Fouladvand F AD - Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: foladvand72@gmail.com. FAU - Panahande, Bahman AU - Panahande B AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: panahande.b@gmail.com. FAU - Nasiri, Morteza AU - Nasiri M AD - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Operating Room Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mortezanasiri.or87@yahoo.com. FAU - Khodadost, Mahmoud AU - Khodadost M AD - Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Electronic address: mahmodkhodadost@yahoo.com. FAU - Shokri, Azad AU - Shokri A AD - Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic address: azad_shokri@yahoo.com. FAU - Pirouzi, Aliyar AU - Pirouzi A AD - Gerash University of Medical Sciences, Gerash, Iran. Electronic address: ali.piroozi1390@gmail.com. FAU - Sadeghi, Omid AU - Sadeghi O AD - Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: osadeghi@razi.tums.ac.ir. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20200328 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 RN - 0 (Biomarkers) RN - 0 (Gluconates) RN - 0 (Lipids) RN - 7733-02-0 (Zinc Sulfate) RN - R4R8J0Q44B (gluconic acid) SB - IM CIN - Nutr Metab Cardiovasc Dis. 2020 Jul 24;30(8):1402-1403. PMID: 32513577 CIN - Nutr Metab Cardiovasc Dis. 2020 Jul 24;30(8):1403-1405. PMID: 32576414 MH - Adult MH - Aged MH - Biomarkers/blood MH - Diabetes Mellitus, Type 2/blood/diagnosis/*drug therapy/epidemiology MH - *Dietary Supplements/adverse effects MH - Dyslipidemias/blood/diagnosis/*drug therapy/epidemiology MH - Female MH - Gluconates/adverse effects/*therapeutic use MH - Humans MH - Lipids/*blood MH - Male MH - Middle Aged MH - Randomized Controlled Trials as Topic MH - Treatment Outcome MH - Zinc Sulfate/adverse effects/*therapeutic use OTO - NOTNLM OT - Clinical trials OT - Diabetes OT - Lipid profile OT - Meta-analysis OT - Zinc COIS- Declaration of Competing Interest The authors declared no personal or financial conflicts of interest. EDAT- 2020/05/27 06:00 MHDA- 2020/11/11 06:00 CRDT- 2020/05/27 06:00 PHST- 2019/10/04 00:00 [received] PHST- 2020/03/06 00:00 [revised] PHST- 2020/03/20 00:00 [accepted] PHST- 2020/05/27 06:00 [pubmed] PHST- 2020/11/11 06:00 [medline] PHST- 2020/05/27 06:00 [entrez] AID - S0939-4753(20)30103-4 [pii] AID - 10.1016/j.numecd.2020.03.021 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2020 Jul 24;30(8):1260-1271. doi: 10.1016/j.numecd.2020.03.021. Epub 2020 Mar 28.