PMID- 32451606
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20240210
IS  - 1432-1831 (Electronic)
IS  - 0300-8584 (Print)
IS  - 0300-8584 (Linking)
VI  - 209
IP  - 4
DP  - 2020 Aug
TI  - Molecular mechanisms of dendritic cell migration in immunity and cancer.
PG  - 515-529
LID - 10.1007/s00430-020-00680-4 [doi]
AB  - Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells 
      that act to bridge innate and adaptive immunity. DCs are critical in mounting 
      effective immune responses to tissue damage, pathogens and cancer. Immature DCs 
      continuously sample tissues and engulf antigens via endocytic pathways such as 
      phagocytosis or macropinocytosis, which result in DC activation. Activated DCs 
      undergo a maturation process by downregulating endocytosis and upregulating 
      surface proteins controlling migration to lymphoid tissues where DC-mediated 
      antigen presentation initiates adaptive immune responses. To traffic to lymphoid 
      tissues, DCs must adapt their motility mechanisms to migrate within a wide 
      variety of tissue types and cross barriers to enter lymphatics. All steps of DC 
      migration involve cell-cell or cell-substrate interactions. This review discusses 
      DC migration mechanisms in immunity and cancer with a focus on the role of 
      cytoskeletal processes and cell surface proteins, including integrins, lectins 
      and tetraspanins. Understanding the adapting molecular mechanisms controlling DC 
      migration in immunity provides the basis for therapeutic interventions to dampen 
      immune activation in autoimmunity, or to improve anti-tumour immune responses.
FAU - de Winde, Charlotte M
AU  - de Winde CM
AUID- ORCID: 0000-0002-8318-4612
AD  - Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University 
      College London, Gower Street, London, WC1E 6BT, UK. l.winde@ucl.ac.uk.
FAU - Munday, Clare
AU  - Munday C
AD  - Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University 
      College London, Gower Street, London, WC1E 6BT, UK.
FAU - Acton, Sophie E
AU  - Acton SE
AUID- ORCID: 0000-0001-9172-0190
AD  - Stromal Immunology Group, MRC Laboratory for Molecular Cell Biology, University 
      College London, Gower Street, London, WC1E 6BT, UK.
LA  - eng
GR  - 19763/CRUK_/Cancer Research UK/United Kingdom
GR  - MC_U12266B/MRC_/Medical Research Council/United Kingdom
GR  - CRUK-A19763/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20200525
PL  - Germany
TA  - Med Microbiol Immunol
JT  - Medical microbiology and immunology
JID - 0314524
RN  - 0 (Chemokines)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Communication/immunology
MH  - Cell Movement/*immunology
MH  - Chemokines/immunology/metabolism
MH  - Cytoskeleton/immunology/metabolism
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Humans
MH  - Membrane Proteins/immunology/metabolism
MH  - Mice
MH  - Neoplasms/*immunology
PMC - PMC7395046
OTO - NOTNLM
OT  - Actin cytoskeleton
OT  - Cell migration
OT  - Dendritic cell
OT  - Integrin
OT  - Lectin
OT  - Tetraspanin
COIS- The authors declare they have no conflict of interest.
EDAT- 2020/05/27 06:00
MHDA- 2021/01/26 06:00
PMCR- 2020/05/25
CRDT- 2020/05/27 06:00
PHST- 2020/03/11 00:00 [received]
PHST- 2020/05/07 00:00 [accepted]
PHST- 2020/05/27 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/05/27 06:00 [entrez]
PHST- 2020/05/25 00:00 [pmc-release]
AID - 10.1007/s00430-020-00680-4 [pii]
AID - 680 [pii]
AID - 10.1007/s00430-020-00680-4 [doi]
PST - ppublish
SO  - Med Microbiol Immunol. 2020 Aug;209(4):515-529. doi: 10.1007/s00430-020-00680-4. 
      Epub 2020 May 25.