PMID- 32451698
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2197-425X (Print)
IS  - 2197-425X (Electronic)
IS  - 2197-425X (Linking)
VI  - 8
IP  - 1
DP  - 2020 May 25
TI  - Heart failure supported by veno-arterial extracorporeal membrane oxygenation 
      (ECMO): a systematic review of pre-clinical models.
PG  - 16
LID - 10.1186/s40635-020-00303-5 [doi]
LID - 16
AB  - OBJECTIVES: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is 
      increasingly being used to treat patients with refractory severe heart failure. 
      Large animal models are developed to help understand physiology and build 
      translational research projects. In order to better understand those experimental 
      models, we conducted a systematic literature review of animal models combining 
      heart failure and VA-ECMO. STUDIES SELECTION: A systematic review was performed 
      using Medline via PubMed, EMBASE, and Web of Science, from January 1996 to 
      January 2019. Animal models combining experimental acute heart failure and ECMO 
      were included. Clinical studies, abstracts, and studies not employing VA-ECMO 
      were excluded. DATA EXTRACTION: Following variables were extracted, relating to 
      four key features: (1) study design, (2) animals and their peri-experimental 
      care, (3) heart failure models and characteristics, and (4) ECMO characteristics 
      and management. RESULTS: Nineteen models of heart failure and VA-ECMO were 
      included in this review. All were performed in large animals, the majority (n = 
      13) in pigs. Acute myocardial infarction (n = 11) with left anterior descending 
      coronary ligation (n = 9) was the commonest mean of inducing heart failure. Most 
      models employed peripheral VA-ECMO (n = 14) with limited reporting. CONCLUSION: 
      Among models that combined severe heart failure and VA-ECMO, there is a large 
      heterogeneity in both design and reporting, as well as methods employed for heart 
      failure. There is a need for standardization of reporting and minimum dataset to 
      ensure translational research achieve high-quality standards.
FAU - Heinsar, Silver
AU  - Heinsar S
AD  - Critical Care Research Group, The Prince Charles Hospital, University of 
      Queensland, Chermside, Brisbane, Australia.
AD  - Second Department of Intensive Care, North Estonia Medical Centre, Talinn, 
      Estonia.
FAU - Rozencwajg, Sacha
AU  - Rozencwajg S
AUID- ORCID: 0000-0001-9030-7994
AD  - Critical Care Research Group, The Prince Charles Hospital, University of 
      Queensland, Chermside, Brisbane, Australia. sacha.rozencwajg@aphp.fr.
AD  - Sorbonne Universite, INSERM, UMRS-1166, ICAN Institute of Cardiometabolism and 
      Nutrition, Medical ICU, Pitie-Salpetriere University Hospital, 47, bd de 
      l'Hopital, 75651, Paris Cedex 13, France. sacha.rozencwajg@aphp.fr.
FAU - Suen, Jacky
AU  - Suen J
AD  - Critical Care Research Group, The Prince Charles Hospital, University of 
      Queensland, Chermside, Brisbane, Australia. j.suen1@uq.edu.au.
FAU - Bassi, Gianluigi Li
AU  - Bassi GL
AD  - Critical Care Research Group, The Prince Charles Hospital, University of 
      Queensland, Chermside, Brisbane, Australia.
FAU - Malfertheiner, Maximilian
AU  - Malfertheiner M
AD  - Critical Care Research Group, The Prince Charles Hospital, University of 
      Queensland, Chermside, Brisbane, Australia.
AD  - Department of Internal Medicine II, Cardiology and Pneumology, University Medical 
      Center Regensburg, Regensburg, Germany.
FAU - Vercaemst, Leen
AU  - Vercaemst L
AD  - Department of Perfusion, University Hospital Gasthuisberg, Louven, Belgium.
FAU - Broman, Lars Mikael
AU  - Broman LM
AD  - ECMO Centre Karolinska, Karolinska University Hospital, Stockholm, Sweden.
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Schmidt, Matthieu
AU  - Schmidt M
AD  - Second Department of Intensive Care, North Estonia Medical Centre, Talinn, 
      Estonia.
FAU - Combes, Alain
AU  - Combes A
AD  - Second Department of Intensive Care, North Estonia Medical Centre, Talinn, 
      Estonia.
FAU - Ratsep, Indrek
AU  - Ratsep I
AD  - Sorbonne Universite, INSERM, UMRS-1166, ICAN Institute of Cardiometabolism and 
      Nutrition, Medical ICU, Pitie-Salpetriere University Hospital, 47, bd de 
      l'Hopital, 75651, Paris Cedex 13, France.
FAU - Fraser, John F
AU  - Fraser JF
AD  - Critical Care Research Group, The Prince Charles Hospital, University of 
      Queensland, Chermside, Brisbane, Australia.
FAU - Millar, Jonathan E
AU  - Millar JE
AD  - Critical Care Research Group, The Prince Charles Hospital, University of 
      Queensland, Chermside, Brisbane, Australia.
AD  - Wellcome-Wolfson Centre for Experimental Medicine, Queen's University Belfast, 
      Belfast, UK.
CN  - European Extracorporeal Life Support Organisation (EuroELSO) Innovations 
      Workgroup & the National Health Medical Research Council Australia Centre of 
      Research Excellence for Advanced Cardio-respiratory Therapies Improving Organ 
      Support (NHMRC CREACTIONS)
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200525
PL  - Germany
TA  - Intensive Care Med Exp
JT  - Intensive care medicine experimental
JID - 101645149
PMC - PMC7248156
OTO - NOTNLM
OT  - Animal models
OT  - Extracorporeal membrane oxygenation
OT  - Heart failure
COIS- The authors declare that they have no conflicts of interests.
EDAT- 2020/05/27 06:00
MHDA- 2020/05/27 06:01
PMCR- 2020/05/25
CRDT- 2020/05/27 06:00
PHST- 2019/10/08 00:00 [received]
PHST- 2020/05/11 00:00 [accepted]
PHST- 2020/05/27 06:00 [entrez]
PHST- 2020/05/27 06:00 [pubmed]
PHST- 2020/05/27 06:01 [medline]
PHST- 2020/05/25 00:00 [pmc-release]
AID - 10.1186/s40635-020-00303-5 [pii]
AID - 303 [pii]
AID - 10.1186/s40635-020-00303-5 [doi]
PST - epublish
SO  - Intensive Care Med Exp. 2020 May 25;8(1):16. doi: 10.1186/s40635-020-00303-5.