PMID- 32452194
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 2501-062X (Electronic)
IS  - 1220-4749 (Linking)
VI  - 58
IP  - 3
DP  - 2020 Sep 1
TI  - Real-life outcomes of unselected acute promyelocytic leukemia patients: a 
      single-center 14-year experience.
PG  - 138-145
LID - 10.2478/rjim-2020-0011 [doi]
AB  - BACKGROUND: After the inclusion of all-trans retinoic acid (ATRA) into the 
      treatment of Acute Promyelocytic leukemia (APL), a notable improvement concerning 
      the survival rates of patients with APL has been observed. However, the 
      population-based studies demonstrated that there was no marked improvement in the 
      survival of patients after the 2000s. We aim to describe the clinical response 
      and prognosis of adult patients diagnosed with APL and examine the change in 
      these outcomes by the time period of diagnosis. METHODS: We retrospectively 
      reviewed thirty-six unselected APL patients who were diagnosed between September 
      2003 and February 2016. RESULTS: The probability of survival at two years was 
      58%, while disease-free survival (DFS) was 87%. The overall early death (ED) rate 
      was 33% and remain stable over time [42% in 2003-2009 vs. 24% in 2010-2016 
      (p=.20)]. In addition, the 2-year overall survival (OS) rates were 47% in 
      2003-2009 and 70% in 2010-2016 (p=.29), and no differences were noted. Univariate 
      analyses showed possible predictors of poor OS were defined as leukocytosis 
      (>/=10x109/L), high Sanz score, hemorrhage, infection, disseminated intravascular 
      coagulopathy (DIC) at presentation and microgranular morphologic subtype. 
      CONCLUSIONS: This study shows that long-term survival remains low in APL 
      patients, particularly related to a high ED rate. Initiatives to reduce ED are 
      exceedingly substantial for improving the survival in APL.
FAU - Akcay, Omer Faruk
AU  - Akcay OF
AD  - Gazi University Faculty of Medicine, Department of Nephrology, Ankara, Turkey.
FAU - Yeter, Haci Hasan
AU  - Yeter HH
AD  - Gazi University Faculty of Medicine, Department of Nephrology, Ankara, Turkey.
FAU - Buyukasik, Yahya
AU  - Buyukasik Y
AD  - Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, 
      Turkey.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Rom J Intern Med
JT  - Romanian journal of internal medicine = Revue roumaine de medecine interne
JID - 9304507
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Disease-Free Survival
MH  - Disseminated Intravascular Coagulation/etiology
MH  - Female
MH  - Hemorrhage/*etiology
MH  - Humans
MH  - Infections/etiology
MH  - Leukemia, Promyelocytic, Acute/complications/*drug therapy/*mortality/pathology
MH  - Leukocytosis/etiology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Survival Rate/trends
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - acute promyelocytic leukemia
OT  - early death
OT  - overall survival
OT  - predictors
OT  - real-life outcomes
EDAT- 2020/05/27 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/05/27 06:00
PHST- 2020/02/10 00:00 [received]
PHST- 2020/05/27 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/05/27 06:00 [entrez]
AID - /j/rjim.ahead-of-print/rjim-2020-0011/rjim-2020-0011.xml [pii]
AID - 10.2478/rjim-2020-0011 [doi]
PST - ppublish
SO  - Rom J Intern Med. 2020 Sep 1;58(3):138-145. doi: 10.2478/rjim-2020-0011.