PMID- 32452529
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20210525
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 108
IP  - 5
DP  - 2020 Nov
TI  - Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions 
      Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes.
PG  - 1078-1089
LID - 10.1002/cpt.1915 [doi]
AB  - Co-trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions 
      (SCARs). This case-control study was conducted to investigate the involvement 
      between genetic variants of human leukocyte antigen (HLA) and CYP2C9 in 
      CTX-induced SCARs, including Stevens-Johnson syndrome (SJS)/toxic epidermal 
      necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms 
      (DRESS) in Thai patients. Thirty cases of CTX-induced SCARs were enrolled and 
      compared with 91 CTX-tolerant controls and 150 people from the general Thai 
      population. Cases comprised 18 SJS/TEN and 12 DRESS patients. This study 
      demonstrated that genetic association of CTX-induced SCARs was 
      phenotype-specific. HLA-B*15:02 and HLA-C*08:01 alleles were significantly 
      associated with CTX-induced SJS/TEN, whereas the HLA-B*13:01 allele was 
      significantly associated with CTX-induced DRESS. In addition, a significant 
      higher frequency of HLA-A*11:01-B*15:02 and HLA-B*13:01-C*03:04 haplotypes were 
      detected in the group of CTX-induced Stevens-Johnson syndrome/toxic epidermal 
      necrolysis (SJS/TEN) and DRESS cases, respectively. Genetic association of 
      CTX-induced SCARs is phenotype-specific. Interestingly, these association was 
      observed only in HIV-infected patients but not in non-HIV-infected patients.
CI  - (c) 2020 The Authors Clinical Pharmacology & Therapeutics (c) 2020 American Society 
      for Clinical Pharmacology and Therapeutics.
FAU - Sukasem, Chonlaphat
AU  - Sukasem C
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), 
      Ramathibodi Hospital, Bangkok, Thailand.
AD  - The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group.
FAU - Pratoomwun, Jirawat
AU  - Pratoomwun J
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), 
      Ramathibodi Hospital, Bangkok, Thailand.
FAU - Satapornpong, Patompong
AU  - Satapornpong P
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), 
      Ramathibodi Hospital, Bangkok, Thailand.
AD  - Division of General Pharmacy Practice, Department of Pharmaceutical Care, Faculty 
      of Pharmacy, Rangsit University, Pathum Thani, Thailand.
FAU - Klaewsongkram, Jettanong
AU  - Klaewsongkram J
AD  - The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group.
AD  - Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of 
      Medicine, Skin and Allergy Research Unit, Chulalongkorn University, Bangkok, 
      Thailand.
AD  - King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
FAU - Rerkpattanapipat, Ticha
AU  - Rerkpattanapipat T
AD  - The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group.
AD  - Division of Allergy Immunology and Rheumatology, Department of Medicine, Faculty 
      of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Rerknimitr, Pawinee
AU  - Rerknimitr P
AD  - The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group.
AD  - Division of Dermatology, Department of Medicine, Faculty of Medicine, Skin and 
      Allergy Research Unit, Chulalongkorn University, Bangkok, Thailand.
FAU - Lertpichitkul, Pattamon
AU  - Lertpichitkul P
AD  - The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group.
AD  - Division of Dermatology, Department of Medicine, Faculty of Medicine, Skin and 
      Allergy Research Unit, Chulalongkorn University, Bangkok, Thailand.
FAU - Puangpetch, Apichaya
AU  - Puangpetch A
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
AD  - Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), 
      Ramathibodi Hospital, Bangkok, Thailand.
FAU - Nakkam, Nontaya
AU  - Nakkam N
AD  - Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Konyoung, Parinya
AU  - Konyoung P
AD  - Pharmacy Unit, Udon Thani Hospital, Udon Thani, Thailand.
FAU - Khunarkornsiri, Usanee
AU  - Khunarkornsiri U
AD  - Pharmacy Unit, Udon Thani Hospital, Udon Thani, Thailand.
FAU - Disphanurat, Wareeporn
AU  - Disphanurat W
AD  - The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group.
AD  - Division of Dermatology, Department of Medicine, Faculty of Medicine, Thammasat 
      University, Pathumthani, Thailand.
FAU - Srisuttiyakorn, Chutika
AU  - Srisuttiyakorn C
AD  - The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group.
AD  - Division of Dermatology, Department of Medicine, Phramongkutklao Hospital, 
      Phramongkutklao College of Medicine, Bangkok, Thailand.
FAU - Pattanacheewapull, Oranuch
AU  - Pattanacheewapull O
AD  - Pharmacy Department, Khon Kaen Hospital, Khon Kaen, Thailand.
FAU - Kanjanawart, Sirimas
AU  - Kanjanawart S
AD  - Pharmacy Unit, Udon Thani Hospital, Udon Thani, Thailand.
FAU - Kongpan, Thachanan
AU  - Kongpan T
AD  - Department of Pathology, Faculty of Medicine, Khon Kaen University, Thailand.
FAU - Chumworathayi, Pansu
AU  - Chumworathayi P
AD  - Pharmacy Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, 
      Thailand.
FAU - Saksit, Niwat
AU  - Saksit N
AD  - School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand.
FAU - Bruminhent, Jackrapong
AU  - Bruminhent J
AD  - Division of Infectious Diseases, Department of Medicine, Faculty of Medicine 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Tassaneeyakul, Wichittra
AU  - Tassaneeyakul W
AD  - Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Chantratita, Wasun
AU  - Chantratita W
AD  - Genomic Medicine Center, Faculty of Medicine Ramathibodi Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Pirmohamed, Munir
AU  - Pirmohamed M
AUID- ORCID: 0000-0002-7534-7266
AD  - Department of Molecular and Clinical Pharmacology, The Royal Liverpool, 
      Broadgreen University Hospitals NHS Trust, MRC Centre for Drug Safety Science, 
      Liverpool Health Partners, University of Liverpool, Liverpool, UK.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200721
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (HLA Antigens)
RN  - 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-Bacterial Agents/*adverse effects
MH  - Case-Control Studies
MH  - Drug Hypersensitivity Syndrome/diagnosis/*genetics/immunology
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HIV Infections/immunology
MH  - HLA Antigens/*genetics/immunology
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stevens-Johnson Syndrome/diagnosis/*genetics/immunology
MH  - Thailand
MH  - Trimethoprim, Sulfamethoxazole Drug Combination/*adverse effects
MH  - Young Adult
EDAT- 2020/05/27 06:00
MHDA- 2021/05/26 06:00
CRDT- 2020/05/27 06:00
PHST- 2019/12/10 00:00 [received]
PHST- 2020/05/15 00:00 [accepted]
PHST- 2020/05/27 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2020/05/27 06:00 [entrez]
AID - 10.1002/cpt.1915 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2020 Nov;108(5):1078-1089. doi: 10.1002/cpt.1915. Epub 2020 
      Jul 21.