PMID- 32454088
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 31
DP  - 2020 Sep
TI  - Comparison of the lamina cribrosa parameters in eyes with exfoliation syndrome, 
      exfoliation glaucoma and healthy subjects.
PG  - 101832
LID - S1572-1000(20)30186-1 [pii]
LID - 10.1016/j.pdpdt.2020.101832 [doi]
AB  - PURPOSE: This study aimed to compare lamina cribrosa (LC) parameters obtained by 
      spectral-domain optical coherence tomography (SD-OCT) of eyes with exfoliation 
      syndrome (PXS), exfoliation glaucoma (PXG) and healthy subjects. METHODS: In this 
      cross-sectional comparative study, 206 eyes of 206 subjects were included. The 
      Bruch's membrane opening distance (BMOd), the anterior and posterior borders of 
      the LC (LC thickness) and the anterior laminar depth (ALD) were imaged using the 
      enhanced depth imaging (EDI) mode of SD-OCT. RESULTS: There were 96 eyes in the 
      PXG group, 55 eyes in the PXS group, and 55 eyes in the control group. The LC 
      thickness was the thinnest in the PXG group (151.10 +/- 51.18 mum), followed in the 
      PXS group (158.76 +/- 49.62 mum), and the thickest in the control group (181.00 +/- 
      39.10 mum) (p = 0.002). In PXG cases where LC was observed in the deepest 
      location, the ALD value was highest (423.92 +/- 111.75 mum) in the PXG group, 
      followed by the control group (403.08 +/- 63.56 mum), and PXS group (357.43 +/- 80.87 
      mum) (p < 0.001). The BMOd values were largest in the PXG group (1542.43 +/- 152.99 
      mum), followed by the control group (1506.52 +/- 169.09 mum) and PXS group (1435.74 +/- 
      141.06 mum) (p < 0.001). In the PXG group, peripapillary retinal nerve fiber layer 
      (pRNFL) thickness, BCVA, and cup to disc (C/D) ratio were also statistically 
      different from the other groups (p < 0.001). CONCLUSION: We found thinner LC 
      thickness in PXG and PXS cases relative to the control group. Although its 
      severity is associated with the diagnosis and severity of glaucoma, LC thinning 
      can be encountered as an isolated condition in the presence of exfoliation.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Topcu, Husna
AU  - Topcu H
AD  - University of Health Sciences, Beyoglu Eye Training and Research Hospital, 
      Istanbul, Turkey. Electronic address: husnaozturk@gmail.com.
FAU - Altan, Cigdem
AU  - Altan C
AD  - University of Health Sciences, Beyoglu Eye Training and Research Hospital, 
      Istanbul, Turkey. Electronic address: cigdem_altan@yahoo.com.
FAU - Cakmak, Semih
AU  - Cakmak S
AD  - University of Health Sciences, Beyoglu Eye Training and Research Hospital, 
      Istanbul, Turkey. Electronic address: semihnr@hotmail.com.
FAU - Alagoz, Nese
AU  - Alagoz N
AD  - University of Health Sciences, Beyoglu Eye Training and Research Hospital, 
      Istanbul, Turkey. Electronic address: alagoznese@gmail.com.
FAU - Pasaoglu, Isil Basgil
AU  - Pasaoglu IB
AD  - University of Health Sciences, Beyoglu Eye Training and Research Hospital, 
      Istanbul, Turkey. Electronic address: ibasgil@yahoo.com.
FAU - Solmaz, Banu
AU  - Solmaz B
AD  - University of Health Sciences, Beyoglu Eye Training and Research Hospital, 
      Istanbul, Turkey. Electronic address: banusatana@gmail.com.
FAU - Basarir, Berna
AU  - Basarir B
AD  - University of Health Sciences, Beyoglu Eye Training and Research Hospital, 
      Istanbul, Turkey. Electronic address: bdemirel@hotmail.com.
FAU - Yasar, Tekin
AU  - Yasar T
AD  - University of Health Sciences, Beyoglu Eye Training and Research Hospital, 
      Istanbul, Turkey. Electronic address: tekinyasar@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20200523
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Exfoliation Syndrome
MH  - *Glaucoma
MH  - Healthy Volunteers
MH  - Humans
MH  - *Optic Disk/diagnostic imaging
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Enhanced depth imaging
OT  - Exfoliation syndrome
OT  - Exfoliative glaucoma
OT  - Lamina cribrosa
OT  - Spectral-domain optical coherence tomography
EDAT- 2020/05/27 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/05/27 06:00
PHST- 2020/03/25 00:00 [received]
PHST- 2020/05/12 00:00 [revised]
PHST- 2020/05/18 00:00 [accepted]
PHST- 2020/05/27 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/05/27 06:00 [entrez]
AID - S1572-1000(20)30186-1 [pii]
AID - 10.1016/j.pdpdt.2020.101832 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2020 Sep;31:101832. doi: 
      10.1016/j.pdpdt.2020.101832. Epub 2020 May 23.