PMID- 32454819
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2020
DP  - 2020
TI  - SLC22A1 rs622342 Polymorphism Predicts Insulin Resistance Improvement in Patients 
      with Type 2 Diabetes Mellitus Treated with Metformin: A Cross-Sectional Study.
PG  - 2975898
LID - 10.1155/2020/2975898 [doi]
LID - 2975898
AB  - BACKGROUND: Metformin is the most widely used oral antidiabetic agent and can 
      reduce insulin resistance (IR) effectively. Organic cation transporter 1 (encoded 
      by SLC22A1) is responsible for the transport of metformin, and 
      ataxia-telangiectasia-mutated (ATM) is a gene relating to the DNA repair and cell 
      cycle control. The aim of this study was to evaluate if the genetic variants in 
      SLC22A1 rs622342 and ATM rs11212617 could be effective predictors of islet 
      function improvement in patients with type 2 diabetes mellitus (T2DM) on 
      metformin treatment. METHODS: This cross-sectional study included 111 patients 
      with T2DM treated with metformin. Genotyping was performed by the dideoxy 
      chain-termination method. The homeostatic indexes of IR (HOMA-IR) and beta-cell 
      function (HOMA-BCF) were determined according to the homeostasis model 
      assessment. RESULTS: Fasting plasma glucose (FPG) levels, HbA(1c) levels, and 
      HOMA-IR were significantly higher in patients with the rs622342 AA genotype than 
      in those with C allele (P < 0.05). However, these significant differences were 
      not observed between rs11212617 genotype groups. Further data analysis revealed 
      that the association between the rs622342 polymorphism and HOMA-IR was gender 
      related, and so was rs11212617 polymorphism and HOMA-BCF. HOMA-IR was 
      significantly higher in males with rs622342 AA genotype than in those with C 
      allele (P=0.021), and HOMA-BCF value was significantly higher in females carrying 
      rs11212617 CC genotype than in those with A allele (P=0.038). The common 
      logarithm (Lg10) of HOMA-BCF was positively correlated with the reciprocal of 
      HbA(1c) (r = 0.629, P < 0.001) and negatively associated with Lg10 FPG 
      (r = -0.708, P < 0.001). CONCLUSIONS: The variant of rs622342 could be a 
      predictor of insulin sensitivity in patients with T2DM treated with metformin. 
      The association between the rs622342 polymorphism and HOMA-IR and the association 
      between the rs11212617 polymorphism and HOMA-BCF were both gender related.
CI  - Copyright (c) 2020 Kunrong Wu et al.
FAU - Wu, Kunrong
AU  - Wu K
AUID- ORCID: 0000-0002-5828-841X
AD  - Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First 
      Medical University, Ji'nan 250014, China.
FAU - Li, Xiaoli
AU  - Li X
AD  - School of Pharmaceutical Sciences, Shandong First Medical University, Tai'an 
      271000, China.
FAU - Xu, Yuedong
AU  - Xu Y
AUID- ORCID: 0000-0001-5078-0234
AD  - Department of Endocrinology and Metabology, The First Affiliated Hospital of 
      Shandong First Medical University, Ji'nan 250014, China.
FAU - Zhang, Xiaoqian
AU  - Zhang X
AUID- ORCID: 0000-0002-8893-9789
AD  - Department of Endocrinology and Metabology, The First Affiliated Hospital of 
      Shandong First Medical University, Ji'nan 250014, China.
FAU - Guan, Ziwan
AU  - Guan Z
AD  - Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First 
      Medical University, Ji'nan 250014, China.
FAU - Zhang, Shufang
AU  - Zhang S
AD  - School of Pharmaceutical Sciences, Shandong First Medical University, Tai'an 
      271000, China.
FAU - Li, Yan
AU  - Li Y
AUID- ORCID: 0000-0002-0039-4818
AD  - Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First 
      Medical University, Ji'nan 250014, China.
LA  - eng
PT  - Journal Article
DEP - 20200508
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC7231067
COIS- No potential conflicts of interest relevant to this article were reported.
EDAT- 2020/05/27 06:00
MHDA- 2020/05/27 06:01
PMCR- 2020/05/08
CRDT- 2020/05/27 06:00
PHST- 2020/01/11 00:00 [received]
PHST- 2020/03/16 00:00 [revised]
PHST- 2020/03/31 00:00 [accepted]
PHST- 2020/05/27 06:00 [entrez]
PHST- 2020/05/27 06:00 [pubmed]
PHST- 2020/05/27 06:01 [medline]
PHST- 2020/05/08 00:00 [pmc-release]
AID - 10.1155/2020/2975898 [doi]
PST - epublish
SO  - Int J Endocrinol. 2020 May 8;2020:2975898. doi: 10.1155/2020/2975898. eCollection 
      2020.