PMID- 32454868
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2020
DP  - 2020
TI  - Antipruritic Effect of Ethyl Acetate Extract from Fructus cnidii in Mice with 
      2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis.
PG  - 6981386
LID - 10.1155/2020/6981386 [doi]
LID - 6981386
AB  - Atopic dermatitis (AD) is a common inflammatory skin disease characterized by 
      intense pruritus and skin lesions. The exact cause of AD is not yet known and the 
      available therapeutic strategies for AD are limited. Fructus cnidii is commonly 
      used in traditional Chinese medicine as an herb for treating chronic itch. 
      However, the mechanism underlying the antipruritic effects of Fructus cnidii is 
      not well understood. In the present study, we investigated the antipruritic 
      effect of locally administered ethyl acetate extract from Fructus cnidii (EAEFC) 
      to 2,4-dinitrofluorobenzene- (DNFB-) induced AD in a mouse model. The scratching 
      behavior, skin thickness, dermatitis score, weight, blood immunoglobulin E (IgE) 
      level, and itch-related cytokine levels were subsequently monitored and 
      evaluated. Results showed that EAEFC treatment attenuated the DNFB-induced 
      AD-like symptoms by alleviating the skin lesions and decreasing the dermatitis 
      score. Hematoxylin and eosin (H&E) and toluidine blue (TB) staining analyses 
      demonstrated that EAEFC mitigated the DNFB-induced increase in skin thickness and 
      prevented the infiltration of mast cells. Behavioral tests showed that EAEFC 
      decreased the DNFB-induced acute and chronic scratching behaviors. Furthermore, 
      EAEFC reduced the levels of itch-related cytokines, such as thymic stromal 
      lymphopoietin (TSLP), interleukin- (IL-) 17, IL-33, and IL-31, and the 
      DNFB-induced boost in serum IgE. Collectively, these results suggest that EAEFC 
      is a potential therapeutic candidate for the treatment of chronic itch in AD.
CI  - Copyright (c) 2020 Xi Chen et al.
FAU - Chen, Xi
AU  - Chen X
AD  - College of Pharmacology, Guangxi Medical University, 22 ShuangYong Road, Nanning 
      530200, China.
FAU - Zhu, Chan
AU  - Zhu C
AD  - School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese 
      Medicine, 138 XianLin Road, Nanjing 210023, China.
FAU - Zhang, Yingge
AU  - Zhang Y
AD  - College of Pharmacology, Guangxi Medical University, 22 ShuangYong Road, Nanning 
      530200, China.
FAU - Yang, Niuniu
AU  - Yang N
AD  - School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese 
      Medicine, 138 XianLin Road, Nanjing 210023, China.
AD  - College of Basic Medicine, Yangzhou University, 88 Daxue South Road, Yangzhou 
      225009, China.
FAU - Shi, Hao
AU  - Shi H
AD  - School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese 
      Medicine, 138 XianLin Road, Nanjing 210023, China.
AD  - Department of Clinical Medicine, Kangda College of Nanjing Medical University, 88 
      ChunHui Road, Lianyungang 222000, China.
FAU - Yang, Weiwei
AU  - Yang W
AD  - School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese 
      Medicine, 138 XianLin Road, Nanjing 210023, China.
FAU - Yang, Yan
AU  - Yang Y
AUID- ORCID: 0000-0002-1860-2857
AD  - School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese 
      Medicine, 138 XianLin Road, Nanjing 210023, China.
FAU - Liang, Jianqiang
AU  - Liang J
AD  - College of Basic Medicine, Guangxi University of Chinese Medicine, 13 WuHe Road, 
      Nanning 530299, China.
FAU - Chen, Liuzhi
AU  - Chen L
AD  - College of Basic Medicine, Guangxi University of Chinese Medicine, 13 WuHe Road, 
      Nanning 530299, China.
FAU - Zeng, Xueying
AU  - Zeng X
AD  - College of Basic Medicine, Guangxi University of Chinese Medicine, 13 WuHe Road, 
      Nanning 530299, China.
FAU - Cai, Rijin
AU  - Cai R
AD  - College of Basic Medicine, Guangxi University of Chinese Medicine, 13 WuHe Road, 
      Nanning 530299, China.
FAU - Wu, Guanyi
AU  - Wu G
AUID- ORCID: 0000-0002-7294-0902
AD  - College of Basic Medicine, Guangxi University of Chinese Medicine, 13 WuHe Road, 
      Nanning 530299, China.
FAU - Tang, Zongxiang
AU  - Tang Z
AUID- ORCID: 0000-0003-2803-0984
AD  - School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese 
      Medicine, 138 XianLin Road, Nanjing 210023, China.
LA  - eng
PT  - Journal Article
DEP - 20200506
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC7229549
COIS- The authors declare that they have no potential conflicts of interest with 
      respect to the research, authorship, and/or publication of this article.
EDAT- 2020/05/27 06:00
MHDA- 2020/05/27 06:01
PMCR- 2020/05/06
CRDT- 2020/05/27 06:00
PHST- 2019/10/04 00:00 [received]
PHST- 2019/12/30 00:00 [revised]
PHST- 2020/01/21 00:00 [accepted]
PHST- 2020/05/27 06:00 [entrez]
PHST- 2020/05/27 06:00 [pubmed]
PHST- 2020/05/27 06:01 [medline]
PHST- 2020/05/06 00:00 [pmc-release]
AID - 10.1155/2020/6981386 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2020 May 6;2020:6981386. doi: 
      10.1155/2020/6981386. eCollection 2020.