PMID- 32454995
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2090-8016 (Print)
IS  - 2090-0597 (Electronic)
IS  - 2090-0597 (Linking)
VI  - 2020
DP  - 2020
TI  - Beta Blocker Therapy in Heart Failure Patients with Active Cocaine Use: A 
      Systematic Review.
PG  - 1985379
LID - 10.1155/2020/1985379 [doi]
LID - 1985379
AB  - BACKGROUND: Cocaine use is associated with multiple cardiovascular complications 
      including heart failure. The use of different types of beta blockers in heart 
      failure patients with active cocaine use is still a matter of debate. In this 
      review, our objective is to systematically review the available literature 
      regarding the use of beta blockers in the treatment of heart failure patients 
      with concurrent cocaine use. METHODS: PubMed, EMBASE, Web of Science, and 
      Clinical Trials.gov were searched from inception to March 2019 using the Medical 
      Subject Headings (MeSH) terms "cocaine", "heart failure", "beta blocker," and 
      "cardiomyopathy". Only studies containing the outcomes of heart failure patients 
      with active cocaine use who were treated with beta blockers were included. 
      RESULTS: The search resulted in 2072 articles out of which 12 were finally 
      included in the review. A total number of participants were 1994 with a median 
      sample size of 111. Most of the studies were retrospective in nature with Oxford 
      Centre for Evidence-Based Medicine (OCEBM) Levels of Evidence from 3 to 5. The 
      main primary outcomes included readmission rates, mortality, left ventricular 
      ejection fraction (LVEF) improvement, New York Heart Association (NYHA) 
      functional class, and major adverse cardiovascular events (MACEs). In the studies 
      analyzed, beta blockers were found to have either a beneficial or a neutral 
      effect on primary outcomes in heart failure patients with active cocaine use. 
      CONCLUSION: The use of beta blocker therapy appears to be safe and beneficial in 
      heart failure patients with active cocaine use, although the evidence is not 
      robust. Furthermore, large-scale studies are required to confirm this finding.
CI  - Copyright (c) 2020 Baldeep K. Mann et al.
FAU - Mann, Baldeep K
AU  - Mann BK
AUID- ORCID: 0000-0001-8006-2479
AD  - Department of Internal Medicine, New York Medical College, Metropolitan Hospital 
      Center, New York, NY 10029, USA.
FAU - Bhandohal, Janpreet S
AU  - Bhandohal JS
AUID- ORCID: 0000-0001-5241-780X
AD  - Department of Internal Medicine, UCLA, Kern Medical Center, Bakersfield, CA 
      93306, USA.
FAU - Saeed, Mohammad
AU  - Saeed M
AUID- ORCID: 0000-0002-6229-728X
AD  - Department of Internal Medicine, New York Medical College, Metropolitan Hospital 
      Center, New York, NY 10029, USA.
FAU - Pekler, Gerald
AU  - Pekler G
AUID- ORCID: 0000-0002-0857-6392
AD  - Division of Cardiology, New York Medical College, Metropolitan Hospital Center, 
      New York, NY 10029, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200508
PL  - United States
TA  - Cardiol Res Pract
JT  - Cardiology research and practice
JID - 101516542
PMC - PMC7231080
COIS- The authors declare that there are no conflicts of interest regarding the 
      publication of this paper.
EDAT- 2020/05/27 06:00
MHDA- 2020/05/27 06:01
PMCR- 2020/05/08
CRDT- 2020/05/27 06:00
PHST- 2019/11/28 00:00 [received]
PHST- 2020/04/22 00:00 [accepted]
PHST- 2020/05/27 06:00 [entrez]
PHST- 2020/05/27 06:00 [pubmed]
PHST- 2020/05/27 06:01 [medline]
PHST- 2020/05/08 00:00 [pmc-release]
AID - 10.1155/2020/1985379 [doi]
PST - epublish
SO  - Cardiol Res Pract. 2020 May 8;2020:1985379. doi: 10.1155/2020/1985379. 
      eCollection 2020.