PMID- 32455208
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 5
IP  - 19
DP  - 2020 May 19
TI  - Ginsenoside Rg1 Regulates Liver Lipid Factor Metabolism in NAFLD Model Rats.
PG  - 10878-10890
LID - 10.1021/acsomega.0c00529 [doi]
AB  - To establish the molecular mechanism of ginsenoside Rg1 in nonalcoholic fatty 
      liver disease (NAFLD), Sprague Dawley (SD) rats (180-220 g) were randomly divided 
      into a control group, model group, ginsenoside Rg1 low-dose group (30 mg/(kg 
      day)), high-dose (60 mg/(kg day)) group, and simvastatin group (1 mg/(kg day)), 
      with 10 SD rats in each group. The control group was given a normal diet. The 
      model group rats were given high-sugar and high-fat diets for 14 weeks. After the 
      model of NAFLD was established successfully, ginsenoside Rg1 was administered 
      orally for 4 or 8 weeks. The results showed that ginsenoside Rg1 decreased the 
      levels of glucose (GLU), insulin (INS), triglyceride (TG), and total cholesterol 
      (TC) and improved liver function. Meanwhile, ginsenoside Rg1 inhibited the 
      secretion of interleukin-1 (IL-1), IL-6, IL-8, IL-18, and tumor necrosis factor-alpha 
      (TNF-alpha) and improved hepatocyte morphology and lipid accumulation in the liver. 
      Furthermore, ginsenoside Rg1 promoted the expression of peroxisome 
      proliferator-activated receptor-alpha (PPAR-alpha), carnitine palmitoyl transferase 1alpha 
      (CPT1A), carnitine palmitoyl transferase 2 (CPT2), and cholesterol 7alpha-hydroxylase 
      (CYP-7A) and inhibited the expression of sterol regulatory element binding 
      proteins-1C (SREBP-1C). In conclusion, ginsenoside Rg1 can inhibit inflammatory 
      reaction, regulate lipid metabolism, and alleviate liver injury in NAFLD model 
      rats.
CI  - Copyright (c) 2020 American Chemical Society.
FAU - Hou, Yunhe
AU  - Hou Y
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Kunming Medical University, Kunming, Yunnan 650500, P. R. China.
AD  - Department of Human Anatomy, College of Basic Medical Sciences, Guilin Medical 
      University, Guilin, Guangxi Zhuang Autonomous Region 541004, P. R. China.
AD  - Department of Chemical Engineering and Industrial Biotechnology, School of Food 
      Engineering, Qingdao Institute of Technology, Qingdao, Shandong 266300, P. R. 
      China.
AD  - Yunnan Province Key Laboratory for Nutrition and Food Safety in Universities, 
      Kunming, Yunnan 650500, P. R. China.
FAU - Gu, Danshan
AU  - Gu D
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Kunming Medical University, Kunming, Yunnan 650500, P. R. China.
AD  - Yunnan Province Key Laboratory for Nutrition and Food Safety in Universities, 
      Kunming, Yunnan 650500, P. R. China.
FAU - Peng, Jianzhi
AU  - Peng J
AD  - Department of Nutrition, The Second Affiliated Hospital of Kunming Medical 
      University, Kunming, Yunnan 650101, P. R. China.
FAU - Jiang, Kerong
AU  - Jiang K
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Kunming Medical University, Kunming, Yunnan 650500, P. R. China.
FAU - Li, Zhigang
AU  - Li Z
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Kunming Medical University, Kunming, Yunnan 650500, P. R. China.
FAU - Shi, Jing
AU  - Shi J
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Kunming Medical University, Kunming, Yunnan 650500, P. R. China.
FAU - Yang, Shikun
AU  - Yang S
AD  - Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, Yunnan 650031, P. R. China.
FAU - Li, Shude
AU  - Li S
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Kunming Medical University, Kunming, Yunnan 650500, P. R. China.
AD  - Yunnan Province Key Laboratory for Nutrition and Food Safety in Universities, 
      Kunming, Yunnan 650500, P. R. China.
FAU - Fan, Xiaoming
AU  - Fan X
AD  - Department of Human Anatomy, College of Basic Medical Sciences, Guilin Medical 
      University, Guilin, Guangxi Zhuang Autonomous Region 541004, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20200505
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
PMC - PMC7241038
COIS- The authors declare no competing financial interest.
EDAT- 2020/05/27 06:00
MHDA- 2020/05/27 06:01
PMCR- 2020/05/05
CRDT- 2020/05/27 06:00
PHST- 2020/02/05 00:00 [received]
PHST- 2020/04/23 00:00 [accepted]
PHST- 2020/05/27 06:00 [entrez]
PHST- 2020/05/27 06:00 [pubmed]
PHST- 2020/05/27 06:01 [medline]
PHST- 2020/05/05 00:00 [pmc-release]
AID - 10.1021/acsomega.0c00529 [doi]
PST - epublish
SO  - ACS Omega. 2020 May 5;5(19):10878-10890. doi: 10.1021/acsomega.0c00529. 
      eCollection 2020 May 19.