PMID- 32456052
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 10
IP  - 5
DP  - 2020 May 22
TI  - Resilience Effects of SGK1 and TAP1 DNA Markers during PRRSV Outbreaks in 
      Reproductive Sows.
LID - 10.3390/ani10050902 [doi]
LID - 902
AB  - The porcine reproductive and respiratory syndrome virus (PRRSV) is a major 
      infectious stressor that causes serious health problems and productivity drops. 
      Based on previous genome-wide analyses, we selected SGK1 and TAP1 as candidate 
      genes for resilience, and genotyped three mutations, including a 3'UTR variant 
      SGK1_rs338508371 and two synonymous variants TAP1_rs1109026889 and 
      TAP1_rs80928141 in 305 Landrace x Large White sows. All polymorphisms affected 
      the reproductive performance in the outbreak, but not during the endemic phase, 
      thereby indicating a potential use of these markers for resilience. Moreover, 
      some genotypes were associated with a stable performance across PRRSV phases. 
      Thus, in the outbreak, the SGK1_rs338508371 AA sows had less piglets born alive 
      (p < 0.0001) and more stillborns (p < 0.05) while other sows were able to keep 
      their productivity. During the outbreak, TAP1_rs80928141 GG sows had less piglets 
      born alive (p < 0.05) and both TAP1 polymorphisms influenced the number of 
      mummies in an additive manner (p < 0.05). Remarkably, TAP1_rs80928141 AA sows had 
      around one mummy more than GG sows (p < 0.01). Resilience to PRRSV could be 
      improved by including the SGK1 and TAP1 markers in crossbreeding and/or selection 
      schemes, as they contribute to maintaining a stable number of piglets born alive 
      and lost, particularly mummies, despite the outbreak.
FAU - Laplana, Marina
AU  - Laplana M
AD  - Departament de Ciencia Animal, Universitat de Lleida-AGROTECNIO Centre, 25198 
      Lleida, Spain.
FAU - Estany, Joan
AU  - Estany J
AD  - Departament de Ciencia Animal, Universitat de Lleida-AGROTECNIO Centre, 25198 
      Lleida, Spain.
FAU - Fraile, Lorenzo Jose
AU  - Fraile LJ
AD  - Departament de Ciencia Animal, Universitat de Lleida-AGROTECNIO Centre, 25198 
      Lleida, Spain.
FAU - Pena, Ramona Natacha
AU  - Pena RN
AUID- ORCID: 0000-0002-3558-7302
AD  - Departament de Ciencia Animal, Universitat de Lleida-AGROTECNIO Centre, 25198 
      Lleida, Spain.
LA  - eng
GR  - COMRDI16-1-0035-03/European Regional Development Fund/
GR  - RTI2018-097700-B-I00/European Regional Development Fund/
GR  - -/Universitat de Lleida (UdL-Impuls programme)/
PT  - Journal Article
DEP - 20200522
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC7278433
OTO - NOTNLM
OT  - DNA markers
OT  - PRRSV
OT  - mummies
OT  - pigs
OT  - reproductive traits
OT  - resilience
OT  - sow
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2020/05/28 06:00
MHDA- 2020/05/28 06:01
PMCR- 2020/05/22
CRDT- 2020/05/28 06:00
PHST- 2020/04/28 00:00 [received]
PHST- 2020/05/14 00:00 [revised]
PHST- 2020/05/19 00:00 [accepted]
PHST- 2020/05/28 06:00 [entrez]
PHST- 2020/05/28 06:00 [pubmed]
PHST- 2020/05/28 06:01 [medline]
PHST- 2020/05/22 00:00 [pmc-release]
AID - ani10050902 [pii]
AID - animals-10-00902 [pii]
AID - 10.3390/ani10050902 [doi]
PST - epublish
SO  - Animals (Basel). 2020 May 22;10(5):902. doi: 10.3390/ani10050902.