PMID- 32457822
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2169-3536 (Print)
IS  - 2169-3536 (Electronic)
IS  - 2169-3536 (Linking)
VI  - 7
DP  - 2019
TI  - Diffuse Correlation Spectroscopy Analysis Implemented on a Field Programmable 
      Gate Array.
PG  - 122503-122512
LID - 10.1109/access.2019.2938085 [doi]
AB  - Diffusive correlation spectroscopy (DCS) is an emerging optical technique that 
      measures blood perfusion in deep tissue. In a DCS measurement, temporal changes 
      in the interference pattern of light, which has passed through tissue, are 
      quantified by an autocorrelation function. This autocorrelation function is 
      further parameterized through a non-linear curve fit to a solution to the 
      diffusion equation for coherence transport. The computational load for this 
      non-linear curve fitting is a barrier for deployment of DCS for clinical use, 
      where real-time results, as well as instrument size and simplicity, are important 
      considerations. We have mitigated this computational bottleneck through 
      development of a hardware analyzer for DCS. This analyzer implements the DCS 
      curving fitting algorithm on digital logic circuit using Field Programmable Gate 
      Array (FPGA) technology. The FPGA analyzer is more efficient than a typical 
      software analysis solution. The analyzer module can be easily duplicated for 
      processing multiple channels of DCS data in real-time. We have demonstrated the 
      utility of this analyzer in pre-clinical large animal studies of spinal cord 
      ischemia. In combination with previously described FPGA implementations of 
      auto-correlators, this hardware analyzer can provide a complete device-on-a-chip 
      solution for DCS signal processing. Such a component will enable new DCS 
      applications demanding mobility and real-time processing.
FAU - Lin, Wei
AU  - Lin W
AD  - Stony Brook University, Stony Brook, NY 11794 USA.
FAU - Busch, David R
AU  - Busch DR
AD  - University of Texas Southwestern, Dallas TX 75390 80523 USA.
FAU - Goh, Chia Chieh
AU  - Goh CC
AD  - Stony Brook University, Stony Brook, NY 11794 USA.
FAU - Barsi, James
AU  - Barsi J
AD  - Stony Brook University, Stony Brook, NY 11794 USA.
FAU - Floyd, Thomas F
AU  - Floyd TF
AD  - Stony Brook University, Stony Brook, NY 11794 USA.
AD  - University of Texas Southwestern, Dallas TX 75390 80523 USA.
LA  - eng
GR  - U01 NS095761/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20190828
PL  - United States
TA  - IEEE Access
JT  - IEEE access : practical innovations, open solutions
JID - 101639462
PMC - PMC7249994
MID - NIHMS1539517
OTO - NOTNLM
OT  - Diffuse Correlation Spectroscopy
OT  - Field Programmable Gate Array
OT  - High Performance Computing
EDAT- 2019/01/01 00:00
MHDA- 2019/01/01 00:01
PMCR- 2020/05/26
CRDT- 2020/05/28 06:00
PHST- 2020/05/28 06:00 [entrez]
PHST- 2019/01/01 00:00 [pubmed]
PHST- 2019/01/01 00:01 [medline]
PHST- 2020/05/26 00:00 [pmc-release]
AID - 10.1109/access.2019.2938085 [doi]
PST - ppublish
SO  - IEEE Access. 2019;7:122503-122512. doi: 10.1109/access.2019.2938085. Epub 2019 
      Aug 28.