PMID- 32458401
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20240207
IS  - 1937-5395 (Electronic)
IS  - 1937-5387 (Linking)
VI  - 13
IP  - 6
DP  - 2020 Dec
TI  - MicroRNA-208a: a Good Diagnostic Marker and a Predictor of no-Reflow in STEMI 
      Patients Undergoing Primary Percutaneuos Coronary Intervention.
PG  - 988-995
LID - 10.1007/s12265-020-10020-9 [doi]
AB  - MicroRNA-208a is a cardiac specific oligo-nucleotide. We aimed at investigating 
      the ability of microRNA-208a to diagnose myocardial infarction and predict the 
      outcome of primary percutaneuos coronary angiography (PCI). Patients (n = 75) 
      presented by chest pain were recruited into two groups. Group 1 (n = 40) had ST 
      elevation myocardial infarction (STEMI) and underwent primary PCI: 21 patients 
      had sufficient reperfusion and 19 had no-reflow. Group 2 (n = 35) had negative 
      cardiac troponins (cTns). Plasma microRNA-208a expression was assessed using 
      quantitative polymerase chain reaction and patients were followed for occurrence 
      of in-hospital major adverse cardiac events (MACE). MicroRNA-208a could diagnose 
      of MI (AUC of 0.926). After primary PCI, it was superior to cTnT in prediction of 
      no-reflow (AUC difference of 0.231, P = 0.0233) and MACE (AUC difference of 
      0.367, P = 0.0053). Accordingly, circulating levels of miR-208a can be used as a 
      diagnostic marker of MI and a predictor of no-reflow and in-hospital MACE. 
      Graphical abstract Receiver operating curve analysis of no-reflow prediction of 
      miRNA208a, CK-MB and hs-Troponin T. MicroRNA-208a shows significantly higher 
      prediction of no-reflow as compared to routine cardiac biomarkers.
FAU - Salama, Aboubakr Mohamed
AU  - Salama AM
AUID- ORCID: 0000-0002-2241-3792
AD  - Cardiovascular Medicine Department, Faculty of Medicine, Zagazig University, 
      Zagazig, 44519, Egypt. abobakr@aucegypt.edu.
AD  - Department of Cardiac Surgery, Verona University, Verona, Italy. 
      abobakr@aucegypt.edu.
AD  - Department of Biotechnology, School of Science and Engineering, American 
      University in Cairo, Cairo, Egypt. abobakr@aucegypt.edu.
FAU - Khalil, Wael Ali
AU  - Khalil WA
AD  - Cardiovascular Medicine Department, Faculty of Medicine, Zagazig University, 
      Zagazig, 44519, Egypt.
FAU - Al-Zaky, Manar
AU  - Al-Zaky M
AD  - Cardiovascular Medicine Department, Faculty of Medicine, Zagazig University, 
      Zagazig, 44519, Egypt.
FAU - Abdallah, Somia Hassan
AU  - Abdallah SH
AD  - Medical Biochemistry Department, Faculty of Medicine, Zagazig University, 
      Zagazig, Egypt.
FAU - Kandil, Nader Talaat
AU  - Kandil NT
AD  - Cardiovascular Medicine Department, Faculty of Medicine, Zagazig University, 
      Zagazig, 44519, Egypt.
FAU - Abdelsabour, Ahmed
AU  - Abdelsabour A
AD  - Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt.
FAU - Shaker, Ahmed Mohammed
AU  - Shaker AM
AD  - Medical Physiology Department, National Research Center, Cairo, Egypt.
FAU - Hasanein, Mesbah Taha
AU  - Hasanein MT
AD  - Cardiovascular Medicine Department, Faculty of Medicine, Zagazig University, 
      Zagazig, 44519, Egypt.
FAU - Luciani, Giovanni Battista
AU  - Luciani GB
AD  - Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of 
      Verona, Verona, Italy.
FAU - Azzazy, Hassan M E
AU  - Azzazy HME
AD  - Department of Chemistry, School of Science and Engineering, The American 
      University in Cairo, Cairo, Egypt.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200526
PL  - United States
TA  - J Cardiovasc Transl Res
JT  - Journal of cardiovascular translational research
JID - 101468585
RN  - 0 (Biomarkers)
RN  - 0 (MIRN208 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Troponin T)
SB  - IM
EIN - J Cardiovasc Transl Res. 2024 Feb 7;:. PMID: 38326541
MH  - Aged
MH  - Biomarkers/blood
MH  - Coronary Angiography
MH  - Female
MH  - Humans
MH  - Male
MH  - MicroRNAs/*blood/genetics
MH  - Middle Aged
MH  - No-Reflow Phenomenon/diagnostic imaging/*etiology
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Predictive Value of Tests
MH  - Real-Time Polymerase Chain Reaction
MH  - ST Elevation Myocardial Infarction/blood/diagnostic imaging/genetics/*therapy
MH  - Treatment Outcome
MH  - Troponin T/blood
OTO - NOTNLM
OT  - MicroRNA
OT  - Myocardial infarction
OT  - No-reflow
OT  - Primary PCI
EDAT- 2020/05/28 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/05/28 06:00
PHST- 2020/01/31 00:00 [received]
PHST- 2020/04/28 00:00 [accepted]
PHST- 2020/05/28 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/05/28 06:00 [entrez]
AID - 10.1007/s12265-020-10020-9 [pii]
AID - 10.1007/s12265-020-10020-9 [doi]
PST - ppublish
SO  - J Cardiovasc Transl Res. 2020 Dec;13(6):988-995. doi: 10.1007/s12265-020-10020-9. 
      Epub 2020 May 26.