PMID- 32459402
OWN - NLM
STAT- MEDLINE
DCOM- 20201008
LR  - 20201008
IS  - 1899-5276 (Print)
IS  - 1899-5276 (Linking)
VI  - 29
IP  - 5
DP  - 2020 May
TI  - The significance of angiotensin II type 1 receptor (AT1 receptor) in renal 
      transplant injury.
PG  - 629-633
LID - 10.17219/acem/121510 [doi]
AB  - Humoral response beyond human leukocyte antigen (HLA) is of great interest in the 
      transplant community. We decided to summarize the data on a new antigenic target 
      called angiotensin II type 1 receptor (AT1 receptor). Non-HLA antibodies can now 
      be detected in routine clinical care of patients after transplantation, but their 
      role is not fully understood. Numerous analyses showed that non-HLA response may 
      exert a higher risk of allograft rejection and allograft loss independently of 
      the HLA system. Non-HLA response may even have a higher rate of antibody-mediated 
      rejection. Information regarding antigen target, as well as the pathophysiology 
      of its antibodies and diagnostic tools, is essential for a better understanding 
      of non-HLA humoral response. Angiotensin II type 1 receptors are the most 
      recognized target for non-HLA antibodies. Anti-AT1R Abs (anti-angiotensin II type 
      1-receptor-activating antibodies) may identify renal transplant patients at 
      higher risk of graft rejection and loss. The presence of AT1 receptor expression 
      analyzed together with anti-AT1R Abs should be considered for better transplant 
      immunological risk assessment. Further assessment is required for a better 
      understanding and to create appropriate therapeutic strategies.
FAU - Sas-Strozik, Agnieszka
AU  - Sas-Strozik A
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, Poland.
FAU - Krajewska, Magdalena
AU  - Krajewska M
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, Poland.
FAU - Banasik, Miroslaw
AU  - Banasik M
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Adv Clin Exp Med
JT  - Advances in clinical and experimental medicine : official organ Wroclaw Medical 
      University
JID - 101138582
RN  - 0 (HLA Antigens)
RN  - 0 (Receptor, Angiotensin, Type 1)
SB  - IM
MH  - Female
MH  - Graft Rejection/*etiology
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Kidney/*injuries/pathology
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Receptor, Angiotensin, Type 1/*immunology
OTO - NOTNLM
OT  - angiotensin AT1 receptor
OT  - anti-AT1R Abs
OT  - antibody-mediated rejection
OT  - non-HLA antibodies
OT  - renal transplantation
EDAT- 2020/05/28 06:00
MHDA- 2020/10/09 06:00
CRDT- 2020/05/28 06:00
PHST- 2020/05/28 06:00 [pubmed]
PHST- 2020/10/09 06:00 [medline]
PHST- 2020/05/28 06:00 [entrez]
AID - 10.17219/acem/121510 [doi]
PST - ppublish
SO  - Adv Clin Exp Med. 2020 May;29(5):629-633. doi: 10.17219/acem/121510.