PMID- 32459795
OWN - NLM
STAT- MEDLINE
DCOM- 20210216
LR  - 20210216
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 26
DP  - 2020 May 27
TI  - Using Cutaneous Receptor Vibration to Uncover the Effect of Transcranial Magnetic 
      Stimulation (TMS) on Motor Cortical Excitability.
PG  - e923166
LID - 10.12659/MSM.923166 [doi]
AB  - BACKGROUND Little is known about how vibrational stimuli applied to hand digits 
      affect motor cortical excitability. The present transcranial magnetic stimulation 
      (TMS) study investigated motor evoked potentials (MEPs) in the upper extremity 
      muscle following high-frequency vibratory digit stimulation. MATERIAL AND METHODS 
      High-frequency vibration was applied to the upper extremity digit II utilizing a 
      miniature electromagnetic solenoid-type stimulator-tactor in 11 healthy study 
      participants. The conditioning stimulation (C) preceded the test magnetic 
      stimulation (T) by inter-stimulus intervals (ISIs) of 5-500 ms in 2 experimental 
      sessions. The TMS was applied over the primary motor cortex for the hand abductor 
      pollicis-brevis (APB) muscle. RESULTS Dunnett's multiple comparisons test 
      indicated significant suppression of MEP amplitudes at ISIs of 200 ms (P=0.001), 
      300 ms (P=0.023), and 400 ms (P=0.029) compared to control. CONCLUSIONS MEP 
      amplitude suppression was observed in the APB muscle at ISIs of 200-400 ms, 
      applying afferent signaling that originates in skin receptors following the 
      vibratory stimuli. The study provides novel insight on the time course and MEP 
      modulation following cutaneous receptor vibration of the hand digit. The results 
      of the study may have implications in neurology in the neurorehabilitation of 
      patients with increased amplitude of MEPs.
FAU - Rogic Vidakovic, Maja
AU  - Rogic Vidakovic M
AD  - Department of Neuroscience, Laboratory for Human and Experimental Neurophysiology 
      (LAHEN), University of Split School of Medicine, Split, Croatia.
FAU - Kostovic, Ana
AU  - Kostovic A
AD  - Department of Neuroscience, Laboratory for Human and Experimental Neurophysiology 
      (LAHEN), University of Split School of Medicine, Split, Croatia.
FAU - Jerkovic, Ana
AU  - Jerkovic A
AD  - Department of Neuroscience, Laboratory for Human and Experimental Neurophysiology 
      (LAHEN), University of Split School of Medicine, Split, Croatia.
FAU - Soda, Josko
AU  - Soda J
AD  - Signal Processing, Analysis and Advanced Diagnostics Research and Education 
      Laboratory (SPAADREL), University of Split Faculty of Maritime Studies, Split, 
      Croatia.
FAU - Russo, Mladen
AU  - Russo M
AD  - Department of Electronics, Faculty of Electrical Engineering, Mechanical 
      Engineering and Naval Architecture, University of Split, Split, Croatia.
FAU - Stella, Maja
AU  - Stella M
AD  - Department of Electronics, Faculty of Electrical Engineering, Mechanical 
      Engineering and Naval Architecture, University of Split, Split, Croatia.
FAU - Knezic, Ante
AU  - Knezic A
AD  - Department of Electronics, Faculty of Electrical Engineering, Mechanical 
      Engineering and Naval Architecture, University of Split, Split, Croatia.
FAU - Vujovic, Igor
AU  - Vujovic I
AD  - Signal Processing, Analysis and Advanced Diagnostics Research and Education 
      Laboratory (SPAADREL), University of Split Faculty of Maritime Studies, Split, 
      Croatia.
FAU - Mihalj, Mario
AU  - Mihalj M
AD  - Department of Neurology, Laboratory of Electromyoneurography, University Hospital 
      of Split, Split, Croatia.
FAU - Baban, Jure
AU  - Baban J
AD  - Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, 
      Croatia.
FAU - Ljubenkov, Davor
AU  - Ljubenkov D
AD  - Department of Electrical Engineering and Computer Science (EECS), KTH Royal 
      Institute of Technology, Stockholm, Sweden.
FAU - Peko, Marin
AU  - Peko M
AD  - Department of Electronics, Faculty of Electrical Engineering, Mechanical 
      Engineering and Naval Architecture, University of Split, Split, Croatia.
FAU - Benzon, Benjamin
AU  - Benzon B
AD  - Department of Neuroscience, Laboratory for Human and Experimental Neurophysiology 
      (LAHEN), University of Split School of Medicine, Split, Croatia.
FAU - Hagelien, Maximilian Vincent
AU  - Hagelien MV
AD  - Department of Neuroscience, Laboratory for Human and Experimental Neurophysiology 
      (LAHEN), University of Split School of Medicine, Split, Croatia.
FAU - Dogas, Zoran
AU  - Dogas Z
AD  - Department of Neuroscience, Laboratory for Human and Experimental Neurophysiology 
      (LAHEN), University of Split School of Medicine, Split, Croatia.
LA  - eng
PT  - Journal Article
DEP - 20200527
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
SB  - IM
MH  - Adult
MH  - Cortical Excitability/physiology
MH  - Electric Stimulation/methods
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Fingers/physiology
MH  - Hand/physiology
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/metabolism/*physiology
MH  - Muscle, Skeletal/physiology
MH  - Transcranial Magnetic Stimulation/*methods
MH  - Vibration
PMC - PMC7275644
COIS- Conflict of interests None.
EDAT- 2020/05/28 06:00
MHDA- 2021/02/17 06:00
PMCR- 2020/05/27
CRDT- 2020/05/28 06:00
PHST- 2020/05/28 06:00 [entrez]
PHST- 2020/05/28 06:00 [pubmed]
PHST- 2021/02/17 06:00 [medline]
PHST- 2020/05/27 00:00 [pmc-release]
AID - 923166 [pii]
AID - 10.12659/MSM.923166 [doi]
PST - epublish
SO  - Med Sci Monit. 2020 May 27;26:e923166. doi: 10.12659/MSM.923166.