PMID- 32460789
OWN - NLM
STAT- MEDLINE
DCOM- 20210101
LR  - 20210101
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 20
IP  - 1
DP  - 2020 May 27
TI  - Frequency of anaplastic lymphoma kinase rearrangements in Moroccan patients with 
      non small cell lung cancer: a multi-institutional national retrospective study.
PG  - 479
LID - 10.1186/s12885-020-06973-4 [doi]
LID - 479
AB  - BACKGROUND: Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor 
      of response to ALK inhibitors in non small cell lung cancer (NSCLC). The 
      prevalence of ALK rearrangements is well known in Whites and Asians. However, 
      data identifying the frequency of this rearrangement in Moroccan and North 
      African population are lacking. The objective of this study is to report the 
      frequency of ALK rearrangement in a group of Moroccan patients with NSCLC. 
      METHODS: A retrospective study was performed enrolling 120 Moroccan patients with 
      NSCLC whose biopsy samples were tested for ALK rearrangement in order to identify 
      the frequency of ALK rearrangement and its potential association with selected 
      variables. The ALK testing was established using fluorescent in situ 
      hybridization (FISH) or immunohistochemistry (IHC). RESULTS: The frequency of ALK 
      rearrangement was 4.2% (5/120). All positive cases were males with advanced 
      adenocarcinoma. ALK rearrangements prevalence was significantly higher in older 
      patients. CONCLUSIONS: The frequency of ALK rearrangements among the Moroccan 
      population tends to correlate with the average frequency reported worldwide, with 
      some specific features. Further prospective studies with larger patients' numbers 
      are needed to verify these findings.
FAU - El Yacoubi, Hind
AU  - El Yacoubi H
AUID- ORCID: 0000-0002-8037-3610
AD  - Research and investigation in medical oncology Moroccan group, Faculty of 
      medicine and pharmacy, Mohammed V University, Impasse souissi, 10100, Rabat, 
      Morocco. drhind@hotmail.fr.
AD  - Department of Medical Oncology, Mohammed Bouafi Hospital, Casablanca, Morocco. 
      drhind@hotmail.fr.
AD  - Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco. 
      drhind@hotmail.fr.
FAU - Sow, Mohamed Lemine
AU  - Sow ML
AD  - Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.
FAU - Kettani, Fouad
AU  - Kettani F
AD  - Department of Pathology, Nations-Unies Pathology Center, Rabat, Morocco.
FAU - Gamra, Lamia
AU  - Gamra L
AD  - Department of Pathology, Hassan Pathology Center, Rabat, Morocco.
FAU - Mestari, Amina
AU  - Mestari A
AD  - Department of Pathology, Agdal Pathology Center, Rabat, Morocco.
FAU - Jabri, Lamia
AU  - Jabri L
AD  - Department of Pathology, Casapath Pathology Center, Casablanca, Morocco.
FAU - Elghissassi, Ibrahim
AU  - Elghissassi I
AD  - Research and investigation in medical oncology Moroccan group, Faculty of 
      medicine and pharmacy, Mohammed V University, Impasse souissi, 10100, Rabat, 
      Morocco.
AD  - Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.
FAU - Errihani, Hassan
AU  - Errihani H
AD  - Research and investigation in medical oncology Moroccan group, Faculty of 
      medicine and pharmacy, Mohammed V University, Impasse souissi, 10100, Rabat, 
      Morocco.
AD  - Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20200527
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
SB  - IM
MH  - Adenocarcinoma/*genetics/pathology
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Anaplastic Lymphoma Kinase/*genetics
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/pathology
MH  - Female
MH  - *Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Morocco
MH  - Retrospective Studies
MH  - Sex Factors
PMC - PMC7251848
OTO - NOTNLM
OT  - Anaplastic lymphoma kinase rearrangement
OT  - Frequency
OT  - Morroco
OT  - Non small cell lung cancer
COIS- The authors declare that they have no competing interests.
EDAT- 2020/05/29 06:00
MHDA- 2021/01/02 06:00
PMCR- 2020/05/27
CRDT- 2020/05/29 06:00
PHST- 2019/08/06 00:00 [received]
PHST- 2020/05/18 00:00 [accepted]
PHST- 2020/05/29 06:00 [entrez]
PHST- 2020/05/29 06:00 [pubmed]
PHST- 2021/01/02 06:00 [medline]
PHST- 2020/05/27 00:00 [pmc-release]
AID - 10.1186/s12885-020-06973-4 [pii]
AID - 6973 [pii]
AID - 10.1186/s12885-020-06973-4 [doi]
PST - epublish
SO  - BMC Cancer. 2020 May 27;20(1):479. doi: 10.1186/s12885-020-06973-4.