PMID- 324608
OWN - NLM
STAT- MEDLINE
DCOM- 19770729
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 2
IP  - 6
DP  - 1977 May
TI  - Inhibitory effects of selenium of the mutagenicity of 2-acetylaminofluorene (AAF) 
      and AAF derivatives.
PG  - 319-22
AB  - Selenium (Se) decreased the mutagenicity of 2-acetylaminofluorene (AAF), 
      N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and N-hydroxyaminofluorene (N-OH-AF) 
      in the Salmonella typhimurium TA 1538 bacterial tester system. Metabolism of AAF 
      and N-OH-AFF to the active mutagen, N-OH-AF, was accomplished by rat liver 
      extracts. Graded decreases in mutagenicity with increasing Se concentrations were 
      observed for each of the three mutagens. Se decreased the mutagenicity of AAF, 
      N-OH-AAF and N-OH-AF to 65, 68 and 61% of their respective controls with mutagen 
      alone. The effective molar ratios of Se to mutagen yielding these decreases were 
      approximately 10:1 (Se:AAF), 10:1 (Se:N-OH-AAF) and 300:1 (Se:N-OH-AF). The 
      largest Se effect observed was accomplished by a molar ratio of 100:1 
      (Se:N-OH-AAF) yielding 28% of the mutagenicity elicited by N-OH-AAF alone.
FAU - Jacobs, M M
AU  - Jacobs MM
FAU - Matney, T S
AU  - Matney TS
FAU - Griffin, A C
AU  - Griffin AC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Fluorenes)
RN  - 53-95-2 (Hydroxyacetylaminofluorene)
RN  - 9M98QLJ2DL (2-Acetylaminofluorene)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - 2-Acetylaminofluorene/*antagonists & inhibitors/metabolism
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Fluorenes/*antagonists & inhibitors
MH  - Hydroxyacetylaminofluorene/analogs & derivatives/*antagonists & 
      inhibitors/metabolism
MH  - In Vitro Techniques
MH  - Microsomes, Liver/metabolism
MH  - Mutation/*drug effects
MH  - Rats
MH  - Salmonella typhimurium/drug effects
MH  - Selenium/administration & dosage/*pharmacology
EDAT- 1977/05/01 00:00
MHDA- 1977/05/01 00:01
CRDT- 1977/05/01 00:00
PHST- 1977/05/01 00:00 [pubmed]
PHST- 1977/05/01 00:01 [medline]
PHST- 1977/05/01 00:00 [entrez]
AID - S0304-3835(77)80011-6 [pii]
AID - 10.1016/s0304-3835(77)80011-6 [doi]
PST - ppublish
SO  - Cancer Lett. 1977 May;2(6):319-22. doi: 10.1016/s0304-3835(77)80011-6.