PMID- 32462376
OWN - NLM
STAT- MEDLINE
DCOM- 20210614
LR  - 20210614
IS  - 1436-5073 (Electronic)
IS  - 0026-3672 (Linking)
VI  - 187
IP  - 6
DP  - 2020 May 28
TI  - Functionalized carbon quantum dots as fluorescent nanoprobe for determination of 
      tetracyclines and cell imaging.
PG  - 351
LID - 10.1007/s00604-020-04328-1 [doi]
AB  - Nitrogen and sulfur co-doped carbon dots (N, S-CQDs) with high fluorescent, 
      water-soluble, low-toxicity properties were synthesized by microwave-assisted 
      hydrothermal approach. The prepared N, S-CDs exhibited high selectivity in 
      detection of tetracyclines (TCs) and displayed a fast-responsive fluorescence 
      quenching signal in the mixture, which are mainly attributed to the inner filter 
      effect (IFE). The synthesized N, S-CQDs are successfully used as a fluorescent 
      nanoprobe for the determination of CTC in milk samples (with excitation/emission 
      maxima at 373/424 nm). The limit of detection (LOD) is 71 ng mL(-1), and the 
      recoveries of spiked samples range from 96 to 104% with a relative standard 
      deviations (RSDs) less than 2.7% (n = 3). Additionally, the cytotoxicity and 
      optical imaging performance of N, S-CQDs were preliminarily evaluated. The 
      results indicate the low-toxicity and good biocompatibility of the N, S-CQDs and 
      their promising future as fluorescent-imaging agents in pharmaceutical analysis. 
      Graphical Abstract Synthesis flowchart and application of nitrogen and sulfur 
      dual-doped carbon quantum dots.
FAU - Zhao, Na
AU  - Zhao N
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe 
      District, Shenyang, 110016, Liaoning Province, People's Republic of China.
FAU - Wang, Yang
AU  - Wang Y
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe 
      District, Shenyang, 110016, Liaoning Province, People's Republic of China.
FAU - Hou, Shanshan
AU  - Hou S
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe 
      District, Shenyang, 110016, Liaoning Province, People's Republic of China.
FAU - Zhao, Longshan
AU  - Zhao L
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe 
      District, Shenyang, 110016, Liaoning Province, People's Republic of China. 
      longshanzhao@163.com.
LA  - eng
PT  - Journal Article
DEP - 20200528
PL  - Austria
TA  - Mikrochim Acta
JT  - Mikrochimica acta
JID - 7808782
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Tetracyclines)
RN  - 70FD1KFU70 (Sulfur)
RN  - 7440-44-0 (Carbon)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Animals
MH  - Carbon/chemistry/toxicity
MH  - Cell Line, Tumor
MH  - Fluorescent Dyes/*chemistry/toxicity
MH  - Food Contamination/analysis
MH  - Humans
MH  - Limit of Detection
MH  - Microscopy, Confocal/methods
MH  - Microscopy, Fluorescence/methods
MH  - Milk/chemistry
MH  - Nitrogen/chemistry/toxicity
MH  - Quantum Dots/*chemistry/toxicity
MH  - Spectrometry, Fluorescence/methods
MH  - Sulfur/chemistry/toxicity
MH  - Tetracyclines/*analysis
OTO - NOTNLM
OT  - Bioimage
OT  - Fluorescence assay
OT  - Inner filter effect
OT  - Quenching
OT  - S-CQDs
EDAT- 2020/05/29 06:00
MHDA- 2021/06/16 06:00
CRDT- 2020/05/29 06:00
PHST- 2020/02/12 00:00 [received]
PHST- 2020/05/15 00:00 [accepted]
PHST- 2020/05/29 06:00 [entrez]
PHST- 2020/05/29 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
AID - 10.1007/s00604-020-04328-1 [pii]
AID - 10.1007/s00604-020-04328-1 [doi]
PST - epublish
SO  - Mikrochim Acta. 2020 May 28;187(6):351. doi: 10.1007/s00604-020-04328-1.