PMID- 32463549
OWN - NLM
STAT- MEDLINE
DCOM- 20210719
LR  - 20210719
IS  - 1868-6982 (Electronic)
IS  - 1868-6974 (Linking)
VI  - 27
IP  - 8
DP  - 2020 Aug
TI  - High-mobility group protein B1: A predictive biomarker for hepatic encephalopathy 
      after transjugular intrahepatic portosystemic shunt.
PG  - 522-530
LID - 10.1002/jhbp.770 [doi]
AB  - BACKGROUND: The aim of the present study was to investigate whether portal level 
      of high-mobility group protein B1 (HMGB1) is associated with hepatic 
      encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS). 
      METHODS: We enrolled 127 consecutive patients who underwent TIPS and collected 
      portal and peripheral blood samples in our department from December 2017 to May 
      2019. HMGB1 levels were determined using enzyme-linked immunosorbent assay kits. 
      HMGB1 and other HE related parameters were estimated by competing risk analysis, 
      receiver operating characteristic (ROC) analysis and Kaplan-Meier analysis. 
      RESULTS: Patients with HE after TIPS were older (P = .019) and had higher portal 
      HMGB1 level (P = .038) than those without. Univariate competing risk analysis: 
      age (sHR 1.025, P = .026), hepatorenal syndrome (sHR 3.149, P = .010), model for 
      end-of-stage liver disease (MELD) score (sHR 1.055, P = .024), prior HE (sHR 
      4.029, P = .0005), portal HMGB1 before TIPS (sHR 1.177, P = .001) reached 
      statistical significance. Multivariate analysis: age (sHR 1.025, P = .037), MELD 
      score (sHR 1.062, P = .011), prior HE (sHR 2.492, P = .030) and portal HMGB1 
      level before TIPS (sHR 1.217, P = .0002) were significantly different. ROC 
      analyses and Kaplan-Meier curve showed portal HMGB1 level changes before and 
      after TIPS (DeltaHMGB1) had good predictive value in the cut-off 0.012 ng/mL 
      (AUC = 0.748, P < .001, Sensitivity = 0.743, Specificity = 0.655). CONCLUSIONS: 
      Portal HMGB1 may be a therapeutic target for post-TIPS HE.
CI  - (c) 2020 Japanese Society of Hepato-Biliary-Pancreatic Surgery.
FAU - Chen, Quan
AU  - Chen Q
AUID- ORCID: 0000-0003-1512-9360
AD  - Department of Interventional Therapy, Peking University Ninth School of Clinical 
      Medicine, Beijing Shijitan Hospital, Beijing, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Interventional Therapy, Peking University Ninth School of Clinical 
      Medicine, Beijing Shijitan Hospital, Beijing, China.
FAU - Yue, Zhen-Dong
AU  - Yue ZD
AD  - Department of Interventional Therapy, Peking University Ninth School of Clinical 
      Medicine, Beijing Shijitan Hospital, Beijing, China.
FAU - Zhao, Hong-Wei
AU  - Zhao HW
AD  - Department of Interventional Therapy, Peking University Ninth School of Clinical 
      Medicine, Beijing Shijitan Hospital, Beijing, China.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Interventional Therapy, Peking University Ninth School of Clinical 
      Medicine, Beijing Shijitan Hospital, Beijing, China.
FAU - Fan, Zhen-Hua
AU  - Fan ZH
AD  - Department of Interventional Therapy, Peking University Ninth School of Clinical 
      Medicine, Beijing Shijitan Hospital, Beijing, China.
FAU - Liu, Fu-Quan
AU  - Liu FQ
AD  - Department of Interventional Therapy, Peking University Ninth School of Clinical 
      Medicine, Beijing Shijitan Hospital, Beijing, China.
LA  - eng
GR  - 81871461/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20200713
PL  - Japan
TA  - J Hepatobiliary Pancreat Sci
JT  - Journal of hepato-biliary-pancreatic sciences
JID - 101528587
RN  - 0 (Biomarkers)
RN  - 0 (HMGB1 Protein)
SB  - IM
MH  - Biomarkers/blood
MH  - Female
MH  - HMGB1 Protein/*blood
MH  - Hepatic Encephalopathy/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Portasystemic Shunt, Transjugular Intrahepatic
MH  - Predictive Value of Tests
MH  - Risk Factors
OTO - NOTNLM
OT  - hepatic encephalopathy
OT  - high-mobility group protein B1
OT  - predictor
OT  - risk factor
OT  - transjugular intrahepatic portosystemic shunt
EDAT- 2020/05/29 06:00
MHDA- 2021/07/20 06:00
CRDT- 2020/05/29 06:00
PHST- 2019/11/21 00:00 [received]
PHST- 2020/02/28 00:00 [revised]
PHST- 2020/03/25 00:00 [accepted]
PHST- 2020/05/29 06:00 [pubmed]
PHST- 2021/07/20 06:00 [medline]
PHST- 2020/05/29 06:00 [entrez]
AID - 10.1002/jhbp.770 [doi]
PST - ppublish
SO  - J Hepatobiliary Pancreat Sci. 2020 Aug;27(8):522-530. doi: 10.1002/jhbp.770. Epub 
      2020 Jul 13.