PMID- 32464186
OWN - NLM
STAT- MEDLINE
DCOM- 20210201
LR  - 20210201
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 217
DP  - 2020 Aug
TI  - Potential of immunotherapies in the mediation of antileukemic responses for 
      patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) - 
      With a focus on Dendritic cells of leukemic origin (DC(leu)).
PG  - 108467
LID - S1521-6616(19)30114-7 [pii]
LID - 10.1016/j.clim.2020.108467 [doi]
AB  - New (non-immunotherapeutic) treatment-strategies for AML/MDS-patients are under 
      development. Dendritic cells (DCs) and 'leukemia-derived DC' (DC(leu)) connect 
      the innate and the adaptive immunesystem and (re-)activate it, in their capacity 
      as professional antigen-presenting cells (APCs). They can be generated ex vivo 
      from peripheral blood mononuclear cells (PBMNCs) or whole blood (WB), containing 
      the -physiological-cellular/soluble microenvironment of individual patients using 
      various DC/DC(leu)-generating methods or (for WB) minimalized 'Kits', containing 
      granulocyte-macrophage-colony-stimulating-factor (GM-CSF) and a second 
      response-modifier. Proof for DC/DC(leu)-mediated activation of the immune-system 
      after T-cell-enriched mixed lymphocyte culture (MLC) is done by flowcytometry, 
      demonstrating increased fractions of certain activated, leukemia-specific or 
      antileukemic cell-subsets of the innate and the adaptive immune-system. 
      Generation of DC/DC(leu) is possible independent of patients' age, MHC-, 
      mutation- or transplantation-status. In vivo-treatment of AML-/MDS-patients with 
      blast-modulating, DC/DC(leu)- inducing 'Kits' could contribute to create 
      migratory DCs, as well as antileukemically reactivated and memory-mediating 
      immune-cells, which patrol tissue and blood and could contribute to stabilizing 
      disease or remissions.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Ansprenger, Christian
AU  - Ansprenger C
AD  - Department for Hematopoetic Cell Transplantation, Working-group: 
      Immune-Modulation, Med. Dept. 3, Klinikum Grosshadern, 
      Ludwig-Maximilians-University, 81377 Munich, Germany. Electronic address: 
      ansprenger@outlook.com.
FAU - Amberger, Daniel Christoph
AU  - Amberger DC
AD  - Department for Hematopoetic Cell Transplantation, Working-group: 
      Immune-Modulation, Med. Dept. 3, Klinikum Grosshadern, 
      Ludwig-Maximilians-University, 81377 Munich, Germany.
FAU - Schmetzer, Helga Maria
AU  - Schmetzer HM
AD  - Department for Hematopoetic Cell Transplantation, Working-group: 
      Immune-Modulation, Med. Dept. 3, Klinikum Grosshadern, 
      Ludwig-Maximilians-University, 81377 Munich, Germany. Electronic address: 
      Schmetzer@med.uni-muenchen.de.
LA  - eng
PT  - Journal Article
DEP - 20200526
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Adaptive Immunity/immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/*pharmacology
MH  - Humans
MH  - Immunity, Innate/immunology
MH  - Immunotherapy/*methods
MH  - Leukemia, Myeloid, Acute/*therapy
MH  - Leukocytes, Mononuclear/cytology/immunology
MH  - Lymphocyte Activation/immunology
MH  - Myelodysplastic Syndromes/*therapy
OTO - NOTNLM
OT  - AML
OT  - DC
OT  - Immunotherapy
OT  - Leukemia derived DC
COIS- Declaration of Competing Interest All authors declare, that there are no 
      financial or competing conflicts in regard to this work.
EDAT- 2020/05/29 06:00
MHDA- 2021/02/02 06:00
CRDT- 2020/05/29 06:00
PHST- 2019/03/01 00:00 [received]
PHST- 2020/03/11 00:00 [revised]
PHST- 2020/05/16 00:00 [accepted]
PHST- 2020/05/29 06:00 [pubmed]
PHST- 2021/02/02 06:00 [medline]
PHST- 2020/05/29 06:00 [entrez]
AID - S1521-6616(19)30114-7 [pii]
AID - 10.1016/j.clim.2020.108467 [doi]
PST - ppublish
SO  - Clin Immunol. 2020 Aug;217:108467. doi: 10.1016/j.clim.2020.108467. Epub 2020 May 
      26.