PMID- 32466330 OWN - NLM STAT- MEDLINE DCOM- 20210316 LR - 20240328 IS - 2073-4425 (Electronic) IS - 2073-4425 (Linking) VI - 11 IP - 5 DP - 2020 May 25 TI - Genetics of Omega-3 Long-Chain Polyunsaturated Fatty Acid Metabolism and Meat Eating Quality in Tattykeel Australian White Lambs. LID - 10.3390/genes11050587 [doi] LID - 587 AB - Meat eating quality with a healthy composition hinges on intramuscular fat (IMF), fat melting point (FMP), tenderness, juiciness, flavour and omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) content. These health-beneficial n-3 LC-PUFA play significant roles in optimal cardiovascular, retinal, maternal and childhood brain functions, and include alpha linolenic (ALA), eicosapentaenoic (EPA), docosahexaenoic (DHA) and docosapentaenoic (DPA) acids. The primary objective of this review was to access, retrieve, synthesise and critically appraise the published literature on the synthesis, metabolism and genetics of n-3 LC-PUFA and meat eating quality. Studies on IMF content, FMP and fatty acid composition were reviewed to identify knowledge gaps that can inform future research with Tattykeel Australian White (TAW) lambs. The TAW is a new sheep breed exclusive to MARGRA brand of lamb with an outstanding low fat melting point (28-39 degrees C), high n-3 LC-PUFA EPA+DHA content (33-69mg/100g), marbling (3.4-8.2%), tenderness (20.0-38.5N) and overall consumer liking (7.9-8.5). However, correlations between n-3 LC-PUFA profile, stearoyl-CoA desaturase (SCD), fatty acid binding protein 4 (FABP4), fatty acid synthase (FASN), other lipogenic genes and meat quality traits present major knowledge gaps. The review also identified research opportunities in nutrition-genetics interactions aimed at a greater understanding of the genetics of n-3 LC-PUFA, feedlot finishing performance, carcass traits and eating quality in the TAW sheep. It was concluded that studies on IMF, FMP and n-3 LC-PUFA profiles in parental and progeny generations of TAW sheep will be foundational for the genetic selection of healthy lamb eating qualities and provide useful insights into their correlations with SCD, FASN and FABP4 genes. FAU - Pewan, Shedrach Benjamin AU - Pewan SB AD - Animal Genetics and Nutrition, Veterinary Sciences Discipline, College of Public Health, Medical and Veterinary Sciences, Division of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia. AD - National Veterinary Research Institute, Private Mail Bag 01, Vom, Plateau State, Nigeria. FAU - Otto, John Roger AU - Otto JR AUID- ORCID: 0000-0002-6578-0787 AD - Animal Genetics and Nutrition, Veterinary Sciences Discipline, College of Public Health, Medical and Veterinary Sciences, Division of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia. FAU - Huerlimann, Roger AU - Huerlimann R AD - Centre for Sustainable Tropical Fisheries and Aquaculture and Centre for Tropical Bioinformatics and Molecular Biology, College of Science and Engineering, James Cook University, Townsville, Queensland 4811, Australia. FAU - Budd, Alyssa Maree AU - Budd AM AD - Centre for Sustainable Tropical Fisheries and Aquaculture and Centre for Tropical Bioinformatics and Molecular Biology, College of Science and Engineering, James Cook University, Townsville, Queensland 4811, Australia. FAU - Mwangi, Felista Waithira AU - Mwangi FW AD - Animal Genetics and Nutrition, Veterinary Sciences Discipline, College of Public Health, Medical and Veterinary Sciences, Division of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia. FAU - Edmunds, Richard Crawford AU - Edmunds RC AD - Animal Genetics and Nutrition, Veterinary Sciences Discipline, College of Public Health, Medical and Veterinary Sciences, Division of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia. FAU - Holman, Benjamin William Behrens AU - Holman BWB AUID- ORCID: 0000-0002-8458-4511 AD - Centre for Red Meat and Sheep Development, NSW Department of Primary Industries, Cowra, New South Wales 2794, Australia. FAU - Henry, Michelle Lauren Elizabeth AU - Henry MLE AD - Gundagai Meat Processors, 2916 Gocup Road, South Gundagai, New South Wales 2722, Australia. AD - Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC 3010, Australia. FAU - Kinobe, Robert Tumwesigye AU - Kinobe RT AUID- ORCID: 0000-0003-1166-0947 AD - Animal Genetics and Nutrition, Veterinary Sciences Discipline, College of Public Health, Medical and Veterinary Sciences, Division of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia. FAU - Adegboye, Oyelola Abdulwasiu AU - Adegboye OA AD - Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, Division of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia. FAU - Malau-Aduli, Aduli Enoch Othniel AU - Malau-Aduli AEO AUID- ORCID: 0000-0002-3660-7862 AD - Animal Genetics and Nutrition, Veterinary Sciences Discipline, College of Public Health, Medical and Veterinary Sciences, Division of Tropical Health and Medicine, James Cook University, Townsville, Queensland 4811, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20200525 PL - Switzerland TA - Genes (Basel) JT - Genes JID - 101551097 RN - 0 (Fatty Acids, Omega-3) RN - 0 (Fatty Acids, Unsaturated) SB - IM MH - Animal Feed MH - Animals MH - Australia MH - Breeding MH - Fatty Acids, Omega-3/*metabolism MH - Fatty Acids, Unsaturated/*metabolism MH - *Food Quality MH - Humans MH - Meat/*analysis MH - Muscle, Skeletal/metabolism MH - Sheep/metabolism PMC - PMC7288343 OTO - NOTNLM OT - MARGRA lamb OT - Tattykeel Australian White OT - fat melting point OT - fat metabolism OT - fatty acid binding protein 4 OT - fatty acid synthase OT - genetics OT - intramuscular fat OT - meat quality OT - omega-3 long-chain polyunsaturated fatty acids OT - stearoyl-CoA desaturase COIS- The authors declare no conflict of interest. The funders had no role in the design of the study; collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. EDAT- 2020/05/30 06:00 MHDA- 2021/03/17 06:00 PMCR- 2020/05/01 CRDT- 2020/05/30 06:00 PHST- 2020/03/04 00:00 [received] PHST- 2020/05/14 00:00 [revised] PHST- 2020/05/21 00:00 [accepted] PHST- 2020/05/30 06:00 [entrez] PHST- 2020/05/30 06:00 [pubmed] PHST- 2021/03/17 06:00 [medline] PHST- 2020/05/01 00:00 [pmc-release] AID - genes11050587 [pii] AID - genes-11-00587 [pii] AID - 10.3390/genes11050587 [doi] PST - epublish SO - Genes (Basel). 2020 May 25;11(5):587. doi: 10.3390/genes11050587.