PMID- 32467543
OWN - NLM
STAT- MEDLINE
DCOM- 20210426
LR  - 20210426
IS  - 0300-5283 (Print)
IS  - 0300-5283 (Linking)
VI  - 75
IP  - 3
DP  - 2020 May
TI  - Species distribution and clinical profiles of coagulase-negative staphylococci 
      (CoNS) isolated from blood cultures among paediatric patients in Hospital Kuala 
      Lumpur.
PG  - 266-273
AB  - INTRODUCTION: Coagulase-negative staphylococci (CoNS) is often considered as a 
      culture contaminants but it can potentially be pathogenic to patients with risk 
      factors. A combination of species identification and clinical criteria has been 
      suggested in determining true CoNS bacteraemia. OBJECTIVES: To identify the 
      species distribution, antibiotic susceptibility patterns and clinical profiles of 
      CoNS isolated from blood cultures among paediatric patients in Hospital Kuala 
      Lumpur (HKL). METHODS: This study involved CoNS isolation from blood cultures of 
      paediatric in-patients of the Paediatric Institute HKL. Isolates were identified 
      to species level using Analytical Profile Index Staph identification strips and 
      antimicrobial susceptibility pattern following Kirby-Bauer Disc Diffusion method. 
      The clinical profiles of patients were obtained from their medical records. 
      RESULTS: Eleven CoNS species were identified from 148 isolates. Staphylococcus 
      epidermidis was the most frequent species isolated (67.6%). The majority of the 
      isolates showed resistance to penicillin (85.8%); while 70.3% were 
      methicillin-resistant (MR) CoNS, which demonstrated a significant association 
      with true infection (p=0.021). Predictors for significant CoNS infection included 
      thrombocytopaenia, presence of predisposing factors, nosocomial infection, blood 
      collected from peripheral vein, and CoNS isolated from two consecutive blood 
      cultures. The most common predisposing factors for the isolation of CoNS were the 
      presence of peripheral (54.1%) and central venous catheters (35.1%). CONCLUSION: 
      CoNS can cause significant bloodstream infections. The isolation of CoNS from 
      blood cultures should be carefully interpreted by considering the predictive 
      factors. Local data regarding predictive factors of patients with 
      culture-positive CoNS, species distribution and antimicrobial susceptibility 
      pattern are useful to determine the significance of blood culture results and 
      care management of patients.
FAU - Siti, N M
AU  - Siti NM
AD  - Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of 
      Medical Microbiology and Parasitology, Malaysia. sitinorbaya@upm.edu.my.
FAU - Wan Nazirah, W A B
AU  - Wan Nazirah WAB
AD  - Hospital Queen Elizabeth, Pathology Department, Microbiology Unit, Kota Kinabalu, 
      Sabah, Malaysia.
FAU - Rosni, I
AU  - Rosni I
AD  - Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of 
      Medical Microbiology and Parasitology, Malaysia.
FAU - Mohamed, A N
AU  - Mohamed AN
AD  - Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of 
      Medical Microbiology and Parasitology, Malaysia.
FAU - Salbiah, N
AU  - Salbiah N
AD  - Hospital Kuala Lumpur, Pathology Department, Microbiology Unit, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Malaysia
TA  - Med J Malaysia
JT  - The Medical journal of Malaysia
JID - 0361547
RN  - 0 (Coagulase)
SB  - IM
MH  - Adolescent
MH  - Bacteremia
MH  - Blood Culture
MH  - Child
MH  - Child, Preschool
MH  - Coagulase/*isolation & purification/metabolism
MH  - Cross Infection
MH  - Cross-Sectional Studies
MH  - *Hospitals
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Malaysia
MH  - Microbial Sensitivity Tests
MH  - *Staphylococcal Infections
MH  - Staphylococcus/drug effects/*isolation & purification
EDAT- 2020/05/30 06:00
MHDA- 2021/04/27 06:00
CRDT- 2020/05/30 06:00
PHST- 2020/05/30 06:00 [entrez]
PHST- 2020/05/30 06:00 [pubmed]
PHST- 2021/04/27 06:00 [medline]
PST - ppublish
SO  - Med J Malaysia. 2020 May;75(3):266-273.