PMID- 32468306
OWN - NLM
STAT- MEDLINE
DCOM- 20201217
LR  - 20201217
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1196
DP  - 2020
TI  - Quality of Life in Type 2 Diabetes Mellitus Patients with Neuropsychological 
      Deficits.
PG  - 41-61
LID - 10.1007/978-3-030-32637-1_5 [doi]
AB  - OBJECTIVE: We investigated: (i) the cognitive performance of type 2 diabetes 
      mellitus (T2DM) patients compared to healthy control participants and (ii) the 
      Health-related Quality of life (HRQOL) of type 2 diabetics with 
      neuropsychological deficits. METHOD: We conducted a prospective study in (N = 44) 
      T2DM patients and (N = 28) demographically matched healthy controls. All 
      participants were assessed with a flexible comprehensive neuropsychological 
      battery of tests that have been standardized in Greece and found to be sensitive 
      in detecting cognitive deficits in type 2 diabetics. They were additionally 
      assessed on measures of general intelligence, general mental state, and 
      depression. They were also administered the WHO QOL-BREF self-report 
      questionnaire to evaluate perceived health-related quality of life. RESULTS: 
      Groups were well matched on baseline demographic characteristics and estimated 
      premorbid intelligence. The groups did not differ on general mental state but 
      varied in the encoding of verbal material, total verbal learning, delayed recall 
      of verbal information, mental information processing speed, phonological and 
      semantic verbal fluency and executive functions, set-shifting. Glycosylated 
      hemoglobin levels and an interaction of age, education, and premorbid 
      intelligence were the most important predictors of domain-specific 
      neuropsychological performance. T2DM patients with deficits in verbal learning, 
      executive functions, set-shifting, and semantic verbal fluency, had significantly 
      lower QOL in the domains of psychological and environmental health, social 
      relationships, and general health, respectively. CONCLUSION: T2DM patients have 
      cognitive deficits on several domains compared to healthy participants. Domain 
      specific neuropsychological deficits in middle aged T2DM patients have a 
      significant impact on HRQOL.
FAU - Marneras, Christos
AU  - Marneras C
AD  - Department of Nursing, University Hospital of Patras, Patras, Greece.
FAU - Messinis, Lambros
AU  - Messinis L
AD  - Neuropsychology Section, University Hospital of Patras, Departments of Psychiatry 
      and Neurology, University of Patras Medical School, Patras, Greece. 
      lmessinis@upatras.gr.
FAU - Ntoskou, Aikaterini
AU  - Ntoskou A
AD  - Neuropsychology Section, University Hospital of Patras, Departments of Psychiatry 
      and Neurology, University of Patras Medical School, Patras, Greece.
FAU - Nasios, Grigorios
AU  - Nasios G
AD  - University of Ioannina, Department of Speech and Language Therapy, Ioannina, 
      Greece.
FAU - Martzoukou, Maria
AU  - Martzoukou M
AD  - University of Ioannina, Department of Speech and Language Therapy, Ioannina, 
      Greece.
FAU - Papathanasopoulos, Panagiotis
AU  - Papathanasopoulos P
AD  - University of Patras Medical School, Patras, Greece.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Diabetes Mellitus, Type 2/*psychology
MH  - Greece
MH  - Humans
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Self Report
OTO - NOTNLM
OT  - Cognitive performance
OT  - Health Related quality of Life (HRQOL)
OT  - Neuropsychological Deficits
OT  - Type 2 Diabetes Mellitus (T2DM)
EDAT- 2020/05/30 06:00
MHDA- 2020/12/18 06:00
CRDT- 2020/05/30 06:00
PHST- 2020/05/30 06:00 [entrez]
PHST- 2020/05/30 06:00 [pubmed]
PHST- 2020/12/18 06:00 [medline]
AID - 10.1007/978-3-030-32637-1_5 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2020;1196:41-61. doi: 10.1007/978-3-030-32637-1_5.