PMID- 32469430
OWN - NLM
STAT- MEDLINE
DCOM- 20210107
LR  - 20210107
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1474
IP  - 1
DP  - 2020 Aug
TI  - Short-term caloric restriction induced bone loss in both axial and appendicular 
      bones by increasing adiponectin.
PG  - 47-60
LID - 10.1111/nyas.14380 [doi]
AB  - Caloric restriction (CR) is well described and has received extensive attention 
      for its multiple benefits, including longevity and stress resistance. However, 
      some studies have shown that CR negatively influences bone, although a mechanism 
      hasn't been provided. Adiponectin, an adipocyte-derived hormone, can affect bone 
      metabolism by various pathways. To explore the role of adiponectin in short-term 
      CR on bone, we tested the effect of short-term CR on limb bones (tibia and femur) 
      and lumbar vertebral bodies of young C57BL/6 wild-type (WT) and 
      adiponectin-deficient (Apn(-/-) ) mice. Two dietary regimes, ad libitum (AL) and 
      CR (70% of the AL diet), were used. Dietary restriction led to increased serum 
      adiponectin in WT mice, while bone mineral density, bone microarchitecture, and 
      biomechanical outcomes of limb bone and vertebrae were decreased. In contrast, 
      bone length, microarchitecture, and biomechanical outcomes were not impaired 
      after CR in Apn(-/-) mice. Furthermore, CR increased adiponectin expression both 
      in white adipose tissue and bone marrow adipose tissue in young WT mice. 
      Histology analysis showed that expansion of bone marrow adipose tissue after CR 
      in Apn(-/-) mice was impaired compared with WT mice. These results suggest that 
      increased adiponectin induced by short-term CR may negatively influence bones.
CI  - (c) 2020 New York Academy of Sciences.
FAU - Zhu, Junxiong
AU  - Zhu J
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
FAU - Liu, Can
AU  - Liu C
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
FAU - Jia, Jialin
AU  - Jia J
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
FAU - Zhang, Chenggui
AU  - Zhang C
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
FAU - Yuan, Wanqiong
AU  - Yuan W
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
FAU - Leng, Huijie
AU  - Leng H
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
AD  - Beijing Key Laboratory of Spinal Diseases, Beijing, China.
FAU - Xu, Yingsheng
AU  - Xu Y
AD  - Department of Neurology, Peking University Third Hospital, Beijing, China.
FAU - Song, Chunli
AU  - Song C
AD  - Department of Orthopedics, Peking University Third Hospital, Beijing, China.
AD  - Beijing Key Laboratory of Spinal Diseases, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20200529
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/blood/*deficiency/genetics
MH  - Animals
MH  - Bone Density/drug effects/*physiology
MH  - Bone Resorption/*physiopathology
MH  - Caloric Restriction/*adverse effects
MH  - Femur/physiology
MH  - Lumbar Vertebrae/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Tibia/physiology
OTO - NOTNLM
OT  - adiponectin
OT  - caloric restriction
OT  - longevity
OT  - osteoporosis
OT  - white adipose tissue
EDAT- 2020/05/30 06:00
MHDA- 2021/01/08 06:00
CRDT- 2020/05/30 06:00
PHST- 2020/03/03 00:00 [received]
PHST- 2020/04/30 00:00 [revised]
PHST- 2020/05/05 00:00 [accepted]
PHST- 2020/05/30 06:00 [pubmed]
PHST- 2021/01/08 06:00 [medline]
PHST- 2020/05/30 06:00 [entrez]
AID - 10.1111/nyas.14380 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2020 Aug;1474(1):47-60. doi: 10.1111/nyas.14380. Epub 2020 May 
      29.