PMID- 32470610
OWN - NLM
STAT- MEDLINE
DCOM- 20210204
LR  - 20210204
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 79
DP  - 2020 Oct
TI  - DHF-BAHPC molecule exerts ameliorative antioxidant status and reduced 
      cadmium-induced toxicity in zebrafish (Danio rerio) embryos.
PG  - 103425
LID - S1382-6689(20)30101-0 [pii]
LID - 10.1016/j.etap.2020.103425 [doi]
AB  - In this study, we report the antioxidant and antitoxic potential of chemically 
      synthesized 4-oxo-2-phenyl-4H-chromene-7,8-diyl 
      bis((1-amino-2-hydroxypropyl)carbamate) (DHF-BAHPC) compound using in vitro and 
      in vivo assays. The DHF-BAHPC was synthesized by linking 7,8-Dihydroxyflavone 
      (DHF) with two molecules of Fmoc-threonine and characterized by 
      Ultraviolet-visible spectroscopy (UV-vis), Fourier-transform infrared 
      spectroscopy (FT-IR), (1)H NMR, (13)C NMR and Mass spectrometry (MS). In vitro, 
      antioxidant assay results revealed that DHF-BAHPC has a dose-dependent radical 
      scavenging potential towards DPPH, ABTS, FRAP and H(2)O(2) radicals with an 
      IC(50) range of 15.45, 66.27, 25.71, 4.375 mug/mL, respectively. Furthermore 
      DHF-BAHPC treatment significantly altered cadmium (Cd) intoxicated zebrafish 
      embryos by rescuing the developmental changes associated with severe histological 
      and reduced the level of defensive antioxidant activities (SOD, CAT, GPx and 
      GST). The overall results of the present study represented that DHF-BAHPC may be 
      used as a potential drug in redox-based therapeutics.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Mohankumar, Thangavel
AU  - Mohankumar T
AD  - Department of Biotechnology, School of Biosciences, Periyar University, Salem 
      636011, Tamil Nadu, India. Electronic address: biomohan7@gmail.com.
FAU - Lalithamba, Haralur Shankaraiah
AU  - Lalithamba HS
AD  - Department of Chemistry, Siddaganga Institute of Technology, Tumakuru 572103, 
      Karnataka, India. Electronic address: lalithambasit@yahoo.co.in.
FAU - Manigandan, Krishnan
AU  - Manigandan K
AD  - Department of Bioscience and Biotechnology, Konkuk University, Seoul, Republic of 
      Korea. Electronic address: biomani1@gmail.com.
FAU - Muthaiyan, Arunachalam
AU  - Muthaiyan A
AD  - Division of Mathematics, Physical and Natural Sciences, University of New Mexico, 
      Gallup, NM 87301, USA. Electronic address: muthaiyan@unm.edu.
FAU - Elangovan, Namasivayam
AU  - Elangovan N
AD  - Department of Biotechnology, School of Biosciences, Periyar University, Salem 
      636011, Tamil Nadu, India. Electronic address: elangovannn@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20200526
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (6,7-dihydroxyflavone)
RN  - 0 (Antioxidants)
RN  - 0 (Benzothiazoles)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Carbamates)
RN  - 0 (Flavones)
RN  - 0 (Picrates)
RN  - 0 (Sulfonic Acids)
RN  - 00BH33GNGH (Cadmium)
RN  - 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
SB  - IM
MH  - Animals
MH  - Antioxidants/chemistry/*pharmacology
MH  - Benzothiazoles/chemistry
MH  - Biphenyl Compounds/chemistry
MH  - Cadmium/*toxicity
MH  - Carbamates/chemistry/*pharmacology
MH  - Embryo, Nonmammalian/abnormalities/*drug effects
MH  - Eye Abnormalities/chemically induced
MH  - Flavones/chemistry/*pharmacology
MH  - Hydrogen Peroxide/chemistry
MH  - Picrates/chemistry
MH  - Sulfonic Acids/chemistry
MH  - Tail/abnormalities/drug effects
MH  - Yolk Sac/abnormalities/drug effects
MH  - *Zebrafish
OTO - NOTNLM
OT  - Antioxidant
OT  - Cadmium
OT  - DHF
OT  - DHF-BAHPC
OT  - Oxidative stress
OT  - Zebrafish embryo
EDAT- 2020/05/30 06:00
MHDA- 2021/02/05 06:00
CRDT- 2020/05/30 06:00
PHST- 2019/07/02 00:00 [received]
PHST- 2020/04/04 00:00 [revised]
PHST- 2020/05/24 00:00 [accepted]
PHST- 2020/05/30 06:00 [pubmed]
PHST- 2021/02/05 06:00 [medline]
PHST- 2020/05/30 06:00 [entrez]
AID - S1382-6689(20)30101-0 [pii]
AID - 10.1016/j.etap.2020.103425 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2020 Oct;79:103425. doi: 10.1016/j.etap.2020.103425. 
      Epub 2020 May 26.