PMID- 32471483
OWN - NLM
STAT- MEDLINE
DCOM- 20210430
LR  - 20210430
IS  - 1916-0216 (Electronic)
IS  - 1916-0208 (Print)
IS  - 1916-0208 (Linking)
VI  - 49
IP  - 1
DP  - 2020 May 29
TI  - Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous 
      cell carcinoma: a systematic review and meta-analysis.
PG  - 31
LID - 10.1186/s40463-020-00421-w [doi]
LID - 31
AB  - BACKGROUND: Several recent studies have indicated that the lymph node ratio (LNR) 
      is an independent prognostic factor for laryngeal and hypopharyngeal squamous 
      cell carcinoma (LHSCC). The purpose of this paper is to assess the prognostic 
      value of LNR and explore appropriate cutoff values by conducting a systematic 
      review and meta-analysis. METHODS: Pubmed, Embase (via Ovid), and Cochrane 
      library were systematically searched for studies on the prognostic value of LNR 
      in LHSCC up to October 31, 2019. Then, Literature review, data extraction, and 
      quality assessment of eligible studies were performed by two independent 
      reviewers back-to-back. Lastly, Stata 14.0 software was hired to conduct a 
      meta-analysis. RESULTS: A total of 445 articles were retrieved, and 13 studies 
      published in English between 2013 and 2019 were included after the title/abstract 
      and full-text screening. Among the 13 studies contributed to 4197 patients, seven 
      studies were about hypopharyngeal squamous cell carcinoma (HPSCC), four studies 
      about laryngeal squamous cell carcinoma (LSCC), and the remaining two studies 
      about LHSCC. The meta-analysis results showed that shorter overall survival (OS) 
      (HR 1.49; 95%CI: 1.18 to 1.88), disease-specific survival (DSS) (HR 1.66; 95%CI: 
      1.32 to 2.07) and disease-free survival (DFS) (HR 2.04; 95%CI: 1.54 to 2.71) were 
      significantly correlated with a higher LNR in a random-effect model. The cutoff 
      values of eligible studies were varied from 0.03 to 0.14, and the lowest 
      significant LNR was 0.044. CONCLUSION: LNR is a valuable prognostic factor in the 
      survival of LHSCC and may be used to improve the tumor staging systems, which, 
      however, requires the solid support of more high-quality studies.
FAU - Abdeyrim, Arikin
AU  - Abdeyrim A
AD  - Department of Otorhinolaryngology Head and Neck Surgery, People's Hospital of 
      Xinjiang Uygur Autonomous Region, 91 Tianchi Road, Tianshan, Urumqi, Xinjiang, 
      830001, China. arikiny@sina.com.
FAU - He, Shizhi
AU  - He S
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, 
      Capital Medical University, Beijing, China.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - Department of Otorhinolaryngology, China-Japan Friendship Hospital, Beijing, 
      China.
FAU - Mamtali, Gulbostan
AU  - Mamtali G
AD  - Department of Otorhinolaryngology Head and Neck Surgery, People's Hospital of 
      Xinjiang Uygur Autonomous Region, 91 Tianchi Road, Tianshan, Urumqi, Xinjiang, 
      830001, China.
FAU - Asla, Aibadla
AU  - Asla A
AD  - Department of Otorhinolaryngology Head and Neck Surgery, People's Hospital of 
      Xinjiang Uygur Autonomous Region, 91 Tianchi Road, Tianshan, Urumqi, Xinjiang, 
      830001, China.
FAU - Yusup, Mirkamil
AU  - Yusup M
AD  - Department of Otorhinolaryngology Head and Neck Surgery, People's Hospital of 
      Xinjiang Uygur Autonomous Region, 91 Tianchi Road, Tianshan, Urumqi, Xinjiang, 
      830001, China.
FAU - Liu, Jiang
AU  - Liu J
AD  - Department of Neurosurgery, China-Japan Friendship Hospital, No. 2, Yinghua East 
      Street, Chaoyang District, Beijing, 100029, China. jiangliusurgery@sina.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200529
PL  - England
TA  - J Otolaryngol Head Neck Surg
JT  - Journal of otolaryngology - head & neck surgery = Le Journal 
      d'oto-rhino-laryngologie et de chirurgie cervico-faciale
JID - 101479544
SB  - IM
MH  - Humans
MH  - Hypopharyngeal Neoplasms/mortality/*pathology/therapy
MH  - Laryngeal Neoplasms/mortality/*pathology/therapy
MH  - *Lymph Node Ratio
MH  - Lymph Nodes/pathology
MH  - Lymphatic Metastasis/pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Publication Bias
MH  - Squamous Cell Carcinoma of Head and Neck/mortality/*pathology/therapy
MH  - Survival Analysis
PMC - PMC7257235
OTO - NOTNLM
OT  - Hypopharyngeal cancer
OT  - Laryngeal cancer
OT  - Lymph node ratio
OT  - Meta-analysis
OT  - Prognosis
COIS- The authors declare that they have no competing interests.
EDAT- 2020/05/31 06:00
MHDA- 2021/05/01 06:00
PMCR- 2020/05/29
CRDT- 2020/05/31 06:00
PHST- 2019/12/13 00:00 [received]
PHST- 2020/04/22 00:00 [accepted]
PHST- 2020/05/31 06:00 [entrez]
PHST- 2020/05/31 06:00 [pubmed]
PHST- 2021/05/01 06:00 [medline]
PHST- 2020/05/29 00:00 [pmc-release]
AID - 10.1186/s40463-020-00421-w [pii]
AID - 421 [pii]
AID - 10.1186/s40463-020-00421-w [doi]
PST - epublish
SO  - J Otolaryngol Head Neck Surg. 2020 May 29;49(1):31. doi: 
      10.1186/s40463-020-00421-w.