PMID- 32471845
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20240329
IS  - 2373-2822 (Electronic)
IS  - 2373-2822 (Linking)
VI  - 7
IP  - 3
DP  - 2020 May/Jun
TI  - Synaptic Connections of Aromatase Circuits in the Medial Amygdala Are Sex 
      Specific.
LID - ENEURO.0489-19.2020 [pii]
LID - 10.1523/ENEURO.0489-19.2020 [doi]
AB  - The brains of male and female mice are shaped by genetics and hormones during 
      development. The enzyme aromatase helps establish sex differences in social 
      behaviors and in the neural circuits that produce these behaviors. The medial 
      amygdala of mice contains a large population of aromatase neurons and is a 
      critical hub in the social behavior network. Moreover, the neural representation 
      of social stimuli in the medial amygdala displays clear sex differences that 
      track developmental changes in social behaviors. Here, we identify a potential 
      anatomic basis for those sex differences. We found that sensory input from the 
      accessory olfactory bulb (AOB) to aromatase neurons is derived nearly exclusively 
      from the anterior AOB, which selectively responds to chemosensory cues from 
      conspecific animals. Through the coordinated use of mouse transgenics and 
      viral-based circuit-tracing strategies, we demonstrate a clear sex difference in 
      the volume of synapses connecting the accessory olfactory bulb to 
      aromatase-expressing neurons in the medial amygdala of male versus female mice. 
      This difference in anatomy likely mediates, at least in part, sex differences in 
      medial amygdala-mediated social behaviors.
CI  - Copyright (c) 2020 Billing et al.
FAU - Billing, Addison
AU  - Billing A
AD  - Neuroscience and Behavior Program, Department of Psychological and Brain 
      Sciences, University of Massachusetts, Amherst, Amherst, Massachusetts 01003.
FAU - Henrique Correia, Marcelo
AU  - Henrique Correia M
AD  - Neuroscience and Behavior Program, Department of Psychological and Brain 
      Sciences, University of Massachusetts, Amherst, Amherst, Massachusetts 01003.
FAU - Kelly, Diane A
AU  - Kelly DA
AD  - Neuroscience and Behavior Program, Department of Psychological and Brain 
      Sciences, University of Massachusetts, Amherst, Amherst, Massachusetts 01003.
FAU - Li, Geng-Lin
AU  - Li GL
AUID- ORCID: 0000-0001-7053-4284
AD  - Neuroscience and Behavior Program, Department of Psychological and Brain 
      Sciences, University of Massachusetts, Amherst, Amherst, Massachusetts 01003.
FAU - Bergan, Joseph F
AU  - Bergan JF
AUID- ORCID: 0000-0002-9386-2595
AD  - Neuroscience and Behavior Program, Department of Psychological and Brain 
      Sciences, University of Massachusetts, Amherst, Amherst, Massachusetts 01003 
      jbergan@umass.edu.
LA  - eng
GR  - R01 MH115094/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200626
PL  - United States
TA  - eNeuro
JT  - eNeuro
JID - 101647362
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Amygdala
MH  - Animals
MH  - *Aromatase/genetics
MH  - *Corticomedial Nuclear Complex
MH  - Female
MH  - Male
MH  - Mice
MH  - Olfactory Bulb
MH  - Social Behavior
PMC - PMC7322293
OTO - NOTNLM
OT  - accessory olfactory bulb
OT  - aromatase
OT  - chemical cues
OT  - circuitry
OT  - medial amygdala
OT  - sex difference
EDAT- 2020/05/31 06:00
MHDA- 2021/06/22 06:00
PMCR- 2020/06/17
CRDT- 2020/05/31 06:00
PHST- 2019/11/21 00:00 [received]
PHST- 2020/04/03 00:00 [revised]
PHST- 2020/04/10 00:00 [accepted]
PHST- 2020/05/31 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/05/31 06:00 [entrez]
PHST- 2020/06/17 00:00 [pmc-release]
AID - ENEURO.0489-19.2020 [pii]
AID - eN-NWR-0489-19 [pii]
AID - 10.1523/ENEURO.0489-19.2020 [doi]
PST - epublish
SO  - eNeuro. 2020 Jun 26;7(3):ENEURO.0489-19.2020. doi: 10.1523/ENEURO.0489-19.2020. 
      Print 2020 May/Jun.