PMID- 32472959
OWN - NLM
STAT- MEDLINE
DCOM- 20211122
LR  - 20211204
IS  - 1521-6551 (Electronic)
IS  - 1521-6543 (Linking)
VI  - 72
IP  - 9
DP  - 2020 Sep
TI  - Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular 
      dysfunction of Alzheimer's disease.
PG  - 1843-1855
LID - 10.1002/iub.2324 [doi]
AB  - Age-related cognitive failure is a main devastating incident affecting even 
      healthy people. Alzheimer's disease (AD) is the utmost common form of dementia 
      among the geriatric community. In the pathogenesis of AD, cerebrovascular 
      dysfunction is revealed before the beginning of the cognitive decline. Mounting 
      proof shows a precarious impact of cerebrovascular dysregulation in the 
      development of AD pathology. Recent studies document that the mammalian target of 
      rapamycin (mTOR) acts as a crucial effector of cerebrovascular dysregulation in 
      AD. The mTOR contributes to brain vascular dysfunction and subsequence cerebral 
      blood flow deficits as well as cognitive impairment. Furthermore, mTOR causes the 
      blood-brain barrier (BBB) breakdown in AD models. Inhibition of mTOR 
      hyperactivity protects the BBB integrity in AD. Furthermore, mTOR drives 
      cognitive defect and cerebrovascular dysfunction, which are greatly prevalent in 
      AD, but the central molecular mechanisms underlying these alterations are 
      obscure. This review represents the crucial and current research findings 
      regarding the role of mTOR signaling in cognitive aging and cerebrovascular 
      dysfunction in the pathogenesis of AD.
CI  - (c) 2020 International Union of Biochemistry and Molecular Biology.
FAU - Uddin, Md Sahab
AU  - Uddin MS
AUID- ORCID: 0000-0002-0805-7840
AD  - Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
AD  - Pharmakon Neuroscience Research Network, Dhaka, Bangladesh.
FAU - Rahman, Md Ataur
AU  - Rahman MA
AD  - Center for Neuroscience, Brain Science Institute, Korea Institute of Science and 
      Technology, Seoul, Republic of Korea.
FAU - Kabir, Md Tanvir
AU  - Kabir MT
AD  - Department of Pharmacy, Brac University, Dhaka, Bangladesh.
FAU - Behl, Tapan
AU  - Behl T
AD  - Chitkara College of Pharmacy, Chitkara University, Patiala, India.
FAU - Mathew, Bijo
AU  - Mathew B
AD  - Division of Drug Design and Medicinal Chemistry Research Lab, Department of 
      Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, India.
FAU - Perveen, Asma
AU  - Perveen A
AD  - Glocal School of Life Sciences, Glocal University, Saharanpur, India.
FAU - Barreto, George E
AU  - Barreto GE
AUID- ORCID: 0000-0002-6644-1971
AD  - Department of Biological Sciences, University of Limerick, Limerick, Ireland.
AD  - Instituto de Ciencias Biomedicas, Universidad Autonoma de Chile, Santiago, Chile.
FAU - Bin-Jumah, May N
AU  - Bin-Jumah MN
AD  - Department of Biology, College of Science, Princess Nourah bint Abdulrahman 
      University, Riyadh, Saudi Arabia.
FAU - Abdel-Daim, Mohamed M
AU  - Abdel-Daim MM
AD  - Department of Zoology, College of Science, King Saud University, Riyadh, Saudi 
      Arabia.
AD  - Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, 
      Ismailia, Egypt.
FAU - Ashraf, Ghulam Md
AU  - Ashraf GM
AD  - King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi 
      Arabia.
AD  - Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, 
      King Abdulaziz University, Jeddah, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200530
PL  - England
TA  - IUBMB Life
JT  - IUBMB life
JID - 100888706
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Alzheimer Disease/*complications
MH  - Animals
MH  - Cerebral Arterial Diseases/etiology/metabolism/*pathology
MH  - *Cerebrovascular Circulation
MH  - *Cognitive Aging
MH  - Cognitive Dysfunction/etiology/metabolism/*pathology
MH  - Disease Models, Animal
MH  - Humans
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - blood-brain barrier
OT  - cerebrovascular dysfunction
OT  - cognitive aging
OT  - mTOR
EDAT- 2020/05/31 06:00
MHDA- 2021/11/23 06:00
CRDT- 2020/05/31 06:00
PHST- 2020/02/29 00:00 [received]
PHST- 2020/05/10 00:00 [revised]
PHST- 2020/05/13 00:00 [accepted]
PHST- 2020/05/31 06:00 [pubmed]
PHST- 2021/11/23 06:00 [medline]
PHST- 2020/05/31 06:00 [entrez]
AID - 10.1002/iub.2324 [doi]
PST - ppublish
SO  - IUBMB Life. 2020 Sep;72(9):1843-1855. doi: 10.1002/iub.2324. Epub 2020 May 30.